Hybrid nanofluid becomes a fascinating research topic due to its thermophysical properties and stability which provide better performance compared to typical nanofluids. Two-phase model for mixed convection magnetohydrodynamic (MHD) flow was investigated incorporating hybrid nanoparticles of Alumina (Al2O3) and Copper (Cu) while the base fluid is water (Cu-Al2O3/water). Three parameters group transformation method (GTM) was employed to transform the mathematical model into a simpler system. The analysis included the effect of magnetic parameter, permeability coefficient, nanoparticle shape factor, temperature ratio, radiation parameter, nanoparticles fraction ratio, Brownian parameter, thermophoresis parameter and Nusselt, Reynold, Prandtl and Sherwood numbers relations. The results showed that the fluid velocity and shear stress were more sensitive to the change of magnetic parameter, M, Prandtl number, Pr, and permeability coefficient, . Moreover, the temperature distribution and the heat flux inside the boundary layer were more sensitive to changing Pr, radiation parameter, Nr , and nanoparticles relative ratio, Nf , while it was less sensitive to changing M. Nusselt–Reynolds number, , reached its highest value 242.7 at then 28.11 at and . Sherwood–Reynolds number, , scored its highest value 83.68 at then 11.03 at temperature ratio difference, , of 10 and .