Myocardial infarction (MI) poses a significant clinical challenge, necessitating expeditious and precise detection to mitigate potentially fatal outcomes. Current MI diagnosis predominantly relies on electrocardiography (ECG); however, it is fraught with limitations, including inter-observer variability and a reliance on expert interpretation. This study introduces an automated MI detection framework that capitalizes on hybrid signal processing methodologies and deterministic learning theory. The initial step involves the extraction of the Shannon energy envelope (SEE) and its derivative from a single-lead ECG. Integration of the SEE into the ECG’s phase portrait provides a means to capture the underlying nonlinear system dynamics. Subsequently, the application of fast and adaptive multivariate empirical mode decomposition (FA-MVEMD) yields discriminative features originating from the most energetically dominant intrinsic mode components (IMFs) within the SEE. Profound dissimilarities are discernible between ECG signals recorded from healthy subjects and those afflicted with MI. In the subsequent phase, deterministic learning theory, implemented through neural networks, is employed to facilitate the classification of ECG signals into two distinct groups. The method’s efficacy is meticulously evaluated using the PTB diagnostic ECG database, resulting in a noteworthy average classification accuracy of 99.21%\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\%$$\\end{document} within a tenfold cross-validation framework. In summation, the findings affirm that the proposed features not only complement conventional ECG attributes but also align closely with the underlying dynamics of the ECG system, ultimately fortifying the automatic detection of MI. The imperative requirement for early and accurate MI diagnosis is addressed through our approach, offering a robust and dependable means to fulfill this pivotal clinical need.