Background: Acetyl cholinesterase inhibition by organo-phosphorus pesticides or organophosphate nerve agents can cause acute parasympathetic system dysfunction, muscle weakness, seizures, coma, and respiratory failure. Prognosis depends on the dose and relative toxicity of the specific compound and pharmaco-kinetic factors. Inability to raise the front part of the foot due to weakness or paralysis of the tibialis anterior muscle. The muscle that lifts the foot, and foot drop occur due to peroneal nerve injury. In Ayurvedic science, the complications and side effects of organophosphate poisoning may be co-related with Kaphavruta Vyana Vata. Methods: It is a single case study. A 27-year male patient came to our OPD with complaints of weakness in bilateral lower limbs for since 4 years. He also complained of impairment in memory and speech deformity. The condition can be correlated with Kaphavruta Vyana Vata and he was treated with Panchakarma treatment including Dhanyamla Dhara, Mustadi-raja Yapana-Basti, Sarvanga Abhyanga, Shashtika Shali Pinda Sweda along with Shamana Chikitsa for one month. Result: Symptomatic assessment of the patient was carried out after one month and during this course, the patient had improvement in symptoms, and the overall quality of life of the patient was significantly improved. Discussion: The patient has been treated with the above-mentioned therapy for symptomatic relief for the management of Kaphavrutha Vyana Vata.
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