The goal of this study was to set-up the basis for climate change adaptation of water resources management policies in Seyhan River basin. The first priority was to identify the balances between water resources and water users with respect to existing and planned projects. In this respect various aspects of Seyhan basin were evaluated, including evaluation of existing water resources, determination of water demand of existing and planned projects, and water resources supply-demand characteristics. The global climate change model was downscaled to the basin scale, the results were associated with hydrometeorological monitoring network and finally the impact of climate change on surface water resources and demands were determined for specific projection years. Water resources management scenarios were developed to evaluate adaptation alternatives to climate change scenarios at the basin level. It was determined that even though there was no water stress in Seyhan basin in 2010, many parts of the basin were expected to suffer significant shortages over the coming years.