You have accessJournal of UrologyCME1 Apr 2023MP77-07 CAUSAL EFFECTS OF MODIFIABLE BEHAVIORS ON PROSTATE CANCER IN EUROPEANS AND EAST ASIANS: A COMPREHENSIVE MENDELIAN RANDOMIZATION STUDY Yongle Zhan, Xiaohao Ruan, Pei Wang, Da Huang, Jingyi Huang, Jinlun Huang, Tsun Tsun Chun, Brian Ho, Ada Ng, James Tsu, and Rong Na Yongle ZhanYongle Zhan More articles by this author , Xiaohao RuanXiaohao Ruan More articles by this author , Pei WangPei Wang More articles by this author , Da HuangDa Huang More articles by this author , Jingyi HuangJingyi Huang More articles by this author , Jinlun HuangJinlun Huang More articles by this author , Tsun Tsun ChunTsun Tsun Chun More articles by this author , Brian HoBrian Ho More articles by this author , Ada NgAda Ng More articles by this author , James TsuJames Tsu More articles by this author , and Rong NaRong Na More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003351.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Early evidence is disputable for the effects of modifiable lifestyle behaviors on prostate cancer (PCa) risk. No research has appraised such causality in different ancestries using a Mendelian randomization (MR) approach. The study aims to infer the causality between common lifestyle behaviors and PCa risks in the European and East Asian populations. METHODS: Two-sample univariable and multivariable MR methods were applied to evaluate the causal relationship between seven types of modifiable lifestyle behaviors and PCa risk, based on genome-wide association studies (GWAS) from PRACTICAL and GAME-ON/ELLIPSE consortia for Europeans (79,148 PCa cases and 61,106 controls), and ChinaPCa consortium for East Asians (3,343 cases and 3,315 controls). Replication was performed using FinnGen (6,311 cases and 88,902 controls) and BioBank Japan data (5,408 cases and 103,939 controls). RESULTS: Tobacco smoking was identified to cause PCa in Europeans (odds ratio [OR]:1.95, 95% confidence interval [CI]:1.09-3.50, p=0.027 per standard deviation increase in the lifetime smoking index). Alcohol drinking (OR:1.05, 95%CI:1.01-1.09, p=0.011) and delayed sexual initiation (OR:1.04, 95%CI:1.00-1.08, p=0.029) were identified to be risk factors while cooked vegetable consumption (OR:0.92, 95%CI:0.88-0.96, p=0.001) to be a protective factor of PCa in East Asians (Figure 1). CONCLUSIONS: Our findings broaden the evidence base for the spectrum of PCa risk factors in different ethnicities, and provide insights into behavioral intervention for PCa in different settings. Source of Funding: This work was in supported by grants from National Natural Science Foundation of China (Grant No. 81972645), Innovative research team of high-level local universities in Shanghai, Shanghai Youth Talent Support Program, intramural funding of The University of Hong Kong to Dr. Rong Na, and Shanghai Sailing Program (22YF1440500) to Dr. Da Huang. All the funders had no role in study design, data collection, data analysis, interpretation, and writing of the report © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1104 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yongle Zhan More articles by this author Xiaohao Ruan More articles by this author Pei Wang More articles by this author Da Huang More articles by this author Jingyi Huang More articles by this author Jinlun Huang More articles by this author Tsun Tsun Chun More articles by this author Brian Ho More articles by this author Ada Ng More articles by this author James Tsu More articles by this author Rong Na More articles by this author Expand All Advertisement PDF downloadLoading ...