Background Infertility adversely affects the general quality of life and sexual satisfaction among women. This study explored the quality of life and sexual concerns among women with secondary infertility in the Tamale metropolis. Methods A qualitative exploratory descriptive design was used. Individual in-depth interviews were conducted using a semi-structured interview guide. Ethical approval was received from the Ghana Health Services ethics review committee. Fourteen (14) participants with secondary infertility receiving treatment at the Tamale Teaching Hospital were purposively selected and interviewed for the study, each lasting about 30 minutes to one hour. The interviews were audiotaped with permission from the participants, transcribed verbatim and content analyzed. Conclusion The findings from this study revealed that happiness, well-being and value in life were compromised among these women. Concerning sexual satisfaction, the majority of the participants experienced low sexual drive and physical pain during sexual intercourse which led to poor sexual satisfaction. There is a need for more exploration into the sexual health of women with infertility