Sexual Disorders In Men Research Articles

Comparison of Premature Ejaculation in Men with Focal Epilepsy and Generalized Tonic-Clonic Epilepsy

Background: Premature ejaculation (PE) is a sexual disorder in men with significant prevalence among neurology patients. Epilepsy is one such condition where the prevalence of PE has been notably high. Objectives: This study aimed to compare the prevalence of PE in men with focal epilepsy and generalized tonic-clonic seizures (GTCS). Methods: In this cross-sectional observational study, 200 patients with epilepsy were included, with 100 patients having focal epilepsy and 100 patients having GTCS. The study utilized the demographic profile form, Men’s Sexual Health Questionnaire (MSHQ), Sexual Quality of Life-Men (SQOL-M), and premature ejaculation diagnostic tool (PEDT). Patients who visited specialized clinics and hospitals and met the inclusion criteria were recruited. Data were then analyzed using SPSS statistical software. Results: The results showed that the mean (SD) age of patients in the focal epilepsy group was 30.18 (3.85). The mean (SD) scores for the MSHQ, SQOL-M, and PEDT tools were 51.81 (11.98), 34.75 (9.36), and 8.63 (4.79), respectively. Although the mean (SD) PE score in the focal epilepsy group was 9.17 (4.49), higher than that of the GTCS group at 8.09 (5.04), the difference was not statistically significant. Additionally, there was a significant relationship between the PEDT score, SQOL-M score, and MSHQ score (P < 0.05). The MSHQ and SQOL-M scores were lower in patients with PE disorder. Conclusions: Sexual disorders, including PE, are significantly prevalent in both groups of patients with epilepsy. Therefore, it is essential to implement both pharmacological and non-pharmacological interventions to reduce the incidence of PE in these patients.

Sexual Disorders in Men: The Main Factors of Occurrence and Their Correction.

The aim is to identify the causes of physical and emotional health disorders in men in terms of intimate interaction with partners, as well as how they can be prevented. The research used comparison, analysis, statistical methods, and surveys. The need for people to discover and study sexual health issues in the modern world in order to support not only the physical, but also the psychological aspects of their body, as well as the impact of lifestyle on this process, is shown. The research was conducted to better understand all diseases that are based on the deterioration of the psycho-emotional state of men, which leads to sexual disorders. A more detailed study of this topic will allow to better select treatment for patients and find different approaches to the problem in the future.

Testing the aphrodisiac effects of Sterculia quadrifida (faloak) bark powder on male white rats (Rattus norvegicus)

Background: Sterculia quadrifida R.Br has been widely known and, empirically, has been widely used as an herbal ingredient to overcome sexual disorders in men. Objective: This study aims to assess the quality, stability, and aphrodisiac properties of faloak bark solution preparations (from plants R.Br Sterculia quadrifida) found on Timor Island, specifically on male white rats of the Wistar strain. Method: This research is a type of experimental research. The activity test used two variations of the formula (50%, 100%) extract, positive and negative control tests. Data were analysed with one-way ANOVA (p < 0.05). Result: The test results of extract quality and stability, including moisture content, resting angle, flow speed, dissolving time, organoleptic test, pH, specific gravity, clarity, and homogeneity, met the requirements. The analysis results found significant differences in each test group (p < 0.05), and there were substantial differences between the negative control group and the positive control group, formula one and formula two. Conclusion: The preparation of the solution of Sterculia quadrifida R. met the established quality and stability. The results of the aphrodisiac test of the effect of Sterculia quadrifida R.Br on the parameters of introduction and climbing activity showed significant activity compared to the negative control group.

Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction.

Background: Erectile dysfunction (ED) stands out as one of the most prevalent sexual disorders in men, with its incidence progressively escalating with age. As delineated by the International Consultation Committee for Sexual Medicine on Definitions/Epidemiology/Risk Factors for Sexual Dysfunction, the prevalence of ED among men under 40 years is estimated to be within the range of 1-10%. The aim of this study was to determine the relationship between the concentration of bioelements (Zn, Cu, Fe, Cr, Mg, and Mn) in the serum and bone tissue and the concentration of selected hormones in men with and without erectile dysfunction. Materials and methods: The retrospective cohort study included 152 men who underwent total hip arthroplasty for hip osteoarthritis at the Department of Orthopaedic Traumatology and Musculoskeletal Oncology at the Pomeranian Medical University in Szczecin. Certain exclusion criteria were applied to ensure the integrity of the study. These included individuals with diabetes, a history of cancer, alcohol abuse, liver or kidney failure, New York Heart Association (NYHA) class III or IV heart failure, and those taking medications that affect bone metabolism, such as mineral supplements, neuroleptics, chemotherapeutic agents, immunosuppressants, corticosteroids, or antidepressants. Patients with hypogonadism or infertility were excluded from the study. Results: The study showed an association between bioT concentrations and Cu concentrations in both patients with and without erectile dysfunction. A correlation between bioactive testosterone and Cr concentrations was also observed in both groups. Patients with erectile dysfunction showed a relationship between bioT concentration and Zn concentration, TT concentration and Mn concentration, FT concentration and Zn concentration, and E2 concentration and Cr concentration. An analysis of elemental concentrations in bone tissue showed an association between FT and Mg and Mn concentrations, but only in patients with erectile dysfunction. In patients without erectile dysfunction, a correlation was observed between FT and Cu concentrations. A correlation was also observed between bioT concentrations and Mg, Mn, and Zn concentrations, but only in patients with erectile dysfunction. In patients without erectile dysfunction, a correlation was observed between bioT and Cu concentrations. Conclusions: Studying the relationship between the concentration of bioelements (Zn, Cu, Fe, Cr, Mg, and Mn) in the serum and bone tissue and the concentration of selected hormones in men may be important in explaining the etiology of the problem. The study of the concentration of Zn and Cu in bone tissue and serum showed that these two elements, regardless of the place of accumulation, may be related to the concentration of androgens in men.

Sexological Diagnosis: Methodology of Diagnosis and Classification of Sexual Disorders in Men

The lecture presented a methodology for assessing sexual health and staging sexological diagnosis. Based on the assessment of the vast clinical material (23 601 married/partner couples and 4113 male patients without a partner, aged 16 to 85, who sought help on their own or on the referral of other doctors to the Kyiv Center for Family Planning, Sexology and Reproductive Health for the period from 1996 to 2019) the main clinical forms of sexual disharmony and sexual dysfunction in men are presented, as well as the frequency of certain forms and their etiopathogenetic study. It also gives examples of sexological diagnoses and methods of statistical encryption according to ICD-10.

Causal effects of gut microbiota on the risk of erectile dysfunction: a Mendelian randomization study.

Erectile dysfunction ranks among the prevalent sexual disorders in men. Several studies have indicated a potential link between gut microbiota and erectile dysfunction. To validate this potential association, we were to screen statistical data from genome-wide association studies of gut microbiota and erectile dysfunction. p values of less than 1 × 10-5 were set as the threshold for screening instrumental variables that were strongly associated with gut microbiota. At the same time, in order to obtain more convincing findings, we further excluded instrumental variables with possible chain imbalance, instrumental variables with the presence of palindromes, instrumental variables with F-statistics less than 10, and instrumental variables associated with risk factors for erectile dysfunction. Five methods including inverse-variance weighted method, weighted median method, weighted mode, Mendelian randomization egger method and Mendelian randomization pleiotropy residual sum and outlier test were then used to analyse the 2591 instrumental variables obtained from the screening. We identified correlations between six gut microbiota and the risk of erectile dysfunction. The genus Ruminococcaceae UCG-013 exhibited an inverse association with the risk of developing erectile dysfunction (0.79 (0.65-0.97), P = 0.0214). Conversely, the genus Tyzzerella3 (1.13 (1.02-1.26), P = 0.0225), genus Erysipelotrichaceae UCG-003 (1.18 (1.01-1.38), P = 0.0412), genus LachnospiraceaeNC2004group (1.19 (1.03-1.37), P = 0.0191), genus Oscillibacter (1.23 (1.08-1.41), P = 0.0022), and family Lachnospiraceae (1.26 (1.05-1.52), P = 0.0123) demonstrated positive associations with an increased risk of erectile dysfunction. These sensitivity analyses of the gut microbiota were consistent. This study demonstrated a possible causal relationship between gut microbiota and erectile dysfunction risk through Mendelian randomization analysis, providing new potential possibilities for the prevention and treatment of erectile dysfunction.

Effectiveness of Onion (Allium Cepa) on the Improvement of Sexual Disorders in Men: A Review Study

Effectiveness of Onion (Allium Cepa) on the Improvement of Sexual Disorders in Men: A Review Study

Treatment of patients with erectile dysfunction by physiotherapy. Literature review

Erectile dysfunction is one of the most frequent sexual disorders in men and is found in 10-52% of men in the general population.
 The disease is polyetiological, involving psychogenic, vascular, neurological, urological, and endocrine mechanisms.
 The relevance of this problem lies in the high damage to the mental health of the patient, leading to a deterioration in his quality of life. In addition, drug therapy with the use of type 5 phosphodiesterase inhibitors is accompanied by headaches, skin flushing, heartburn, nasal congestion and dizziness, visual impairment, and muscle pain. In this regard, it became necessary to use physiotherapeutic methods of treatment to restore erectile function with minimal side effects.
 This review also presents pathogenetic substantiated basic physiotherapeutic methods for treating patients with erectile dysfunction using pelvic floor muscle training, aerobic sports exercises, transcutaneous electrical nerve stimulation, manual therapy and mechanical vibration therapy.

Study of the Effectiveness of Combined Use Dietary Supplements for Sexual Disorders in Men with Chronic Prostatitis

Study of the Effectiveness of Combined Use Dietary Supplements for Sexual Disorders in Men with Chronic Prostatitis

Investigating the Rate of Sexual Disorders in Men With a Recent COVID-19 Infection Referred to the Tadbir Clinic in Urmia

Introduction The Covid-19 pandemic has had destructive social, psychological, and economic effects worldwide. Various studies reported a decrease in male sexual potency during the covid-19 pandemic and an increase in patients with erectile dysfunction disorders. The present study seeks to determine the rate of sexual disorders in men with a recent history of COVID-19. Methods The present study adopted a prospective design. The study population included patients referred to the lung and urology clinic at Tadbir Clinic in Urmia City in the previous two months, from 2020 to 2021, with recent complaints of impotence or its exacerbation. The International Index of Erectile Function (IIEF) questionnaire was administered to the patients to collect data regarding their sexual activity. Based on the scores obtained from the questionnaire, the patients were divided into three groups: those without disorders, those with mild to moderate disorders, and those with moderate to severe disorders. Results The mean sexual score in patients was 15.68 ± 6.06. While 17.4% of the patients did not have erectile dysfunction, 82.6% had some degree of erectile dysfunction. The prevalence of erectile dysfunction among patients hospitalized in the ICU was significantly higher than among those hospitalized in the ward. Patients with a history of hospitalization had a lower average sex score than those without a history of hospitalization. Conclusion The rate of sexual dysfunction in patients with a history of hospitalization in the ward and ICU was higher. Moreover, patients who had been hospitalized in the ICU were more likely to develop sexual dysfunction than those who had been hospitalized in the ward. This study found that Covid-19 had a significant impact on male sexual health.

Efficacy of Low-Intensity Extra Corporal Shockwave Therapy (LI-ESWT) in Patients With Erectile Dysfunction.

Erectile dysfunction (ED) is a common cause of sexual disorders in men with limited treatment options. This study aimed to determine the efficacy of low-intensity extra corporal shockwave therapy (LI-ESWT) in patients suffering from ED. A single-group, pre-test, and post-test pre-experimental study were conducted. Thirty-one ED patients were prospectively selected according to the eligibility criteria. In each session, 3000 shocks were applied at 5 points over the penis. Eight sessions were delivered in total with a 2-3-day interval. The patient's condition was assessed using the International Index of Electric Function (IIEF-5) questionnaire at baseline and one month after the last treatment session. Paired t-test was used to determine the difference between the pre-test and post-test. Mean age of the patients was 44.6 (± 14.70) ranging from 25 to 78 years. The majority of them were married (83.9%) and service providers (51.6%). We have also found 51.6% overweight, 9.7% obese, 48.4% diabetic, 45.2% hypertensive, 12.9% with enlarged prostate, 45.2% smoker, 25.8% alcoholic, and 71% with sleep disturbances. During the pre-test, 9.7% had severe ED and 51.6% had moderate ED. After the treatment, no patients were found with severe ED, and few of them had moderate ED (9.7%). The mean difference in IIEF-5 score during the pre-test and post-test was statistically significant (p= < 0.001). The study showed efficacy of LI-ESWT in a subset of patients with ED. Future studies with larger sample size, placebo group, and longer follow-up periods are recommended.

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction.

Organic erectile dysfunction (ED) is a type of sexual disorder in men that is usually associated with illness, surgical injury, normal aging and has a high incidence across the globe. And the essence of penile erection is a neurovascular event regulated by a combination of factors. Nerve and vascular injury are the main causes of erectile dysfunction. Currently, the main treatment options for ED include phosphodiesterase type 5 inhibitors (PDE5Is), intracorporeal injections and vacuum erection devices (VEDs), which are ineffective. Therefore, it is essential to find an emerging, non-invasive and effective treatment for ED. The histopathological damage causing ED can be improved or even reversed with hydrogels, in contrast to current therapies. Hydrogels have many advantages, they can be synthesized from various raw materials with different properties, possess a definite composition, and have good biocompatibility and biodegradability. These advantages make hydrogels an effective drug carrier. In this review, we began with an overview of the underlying mechanisms of organic erectile dysfunction, discussed the dilemmas of existing treatments for ED, and described the unique advantages of hydrogel over other approaches. Then emphasizing the progress of research on hydrogels in the treatment of ED.

Psychopathological aspects of compulsive sexual behavior in males

The article is devoted to the study of the clinical picture of compulsive sexual disorders in men as a manifestation of various mental disorders. The authors compare and analyze psychopathological features in patients with compulsive behavioral disorders in the form of compulsive masturbation within four different clinical groups. Concurrently, the presence and clinical and psychopathological features of such a phenomenon as a compulsive sexual disorder are considered not only as an important diagnostic criterion for the qualification of mental disorder, but also for the development of adequate therapeutic measures. The article proposes a program of effective therapy and rehabilitation for these disorders.

Sexual disorders in men treated in a psychiatric ward

To assess the impact of mental illness and addiction ( dual diagnosis -DD) on the prevalence and frequency of sexual disorders in men hospitalized in a psychiatric ward. The association between sexual disorders and age, having a partner and taking treatment were also studied. The total of 140 men with diagnosis of schizophrenia, affective disorders, anxiety disorders, addiction, dual diagnosis ( schizophrenia and addiction) were enrolled to the study during hospitalization in psychiatric ward. International Index of Erectile Function-5 and The Sexual questionnaire constructed by A. Kokoszka were used to assess examined parameters. The sexual disorders was recorded in 83.6% participates. Reduction in sexual needs (53.6%) and orgasm delay (40%) were the most common. Erectile dysfunction appeared in 38.6% of responders examined by Kokoszka Questionnaire and 61.4% patients assessed by IIEF-5. Severe erectile dysfunction was more common in single participates in comparison to the patients in relationship (12,4% vs 0, p =0.000) and in anxiety patients ( p=0.028) compared to patients with other disorders. In the group of patients with dual diagnosis sexual dysfunction was observed more frequent then in patients with schizophrenia (p=0.034). Treatment lasting over 5 years was more often associated with sexual dysfunction (p=0.007) . In DD patients lack of orgasm and excessive sexual needs were frequent than in patients with single diagnosis ( p=0.0145; p=0.035) . Sexual disorders are more common in DD patients in comparison to schizophrenic patients. More frequent occurrence of sexual disorders is associated with the lack of partners and with over 5 years psychiatric treatment. There is no conflict of interest for all authors. The work has been published in Psychiatria Polska DOI: https://doi.org/10.12740/PP/OnlineFirst/136102

Sexual disorders in men treated in a psychiatric ward

Sexual disorders in men treated in a psychiatric ward

Delayed ejaculation in men with depressive disorders.

Delayed ejaculation belongs to the group of sexual disorders in men. The causes of delayed ejaculation or anejaculation are not exactly known. It is assumed that it can be caused by psychogenic or organic influences or their combinations. One of the causes of delayed ejaculation may be elevated prolactin levels, which may be increased by psychosocial stress, pituitary disorders or also treatment with selective serotonin reuptake inhibitors in the treatment of depression. We tested a selected group of 50 men who were diagnosed with a depressive disorder and whose antidepressant treatment lasted for at least 24weeks. These patients reported long-term delayed ejaculation or, in some cases, anejaculation as comorbidity. The results showed significant Spearman's correlation between elevated prolactin levels and intravaginal ejaculation latency values (R=0.45), as well as between Beck's Depression-II inventory and intravaginal ejaculation latency and latency values (R=0.48).

Androgen regulated protein and pyruvate dehydrogenase kinase 4 in severe erectile dysfunction: A gene expression analysis, and computational study of protein structure.

Erectile dysfunction (ED) is one of the most common sexual disorders in men. During the past 30 years, there has been no new drug development for ED. Thus, exploring the genetic basis of ED deserves further study, in hope of developing new pharmacological treatments for ED. In this study, Real-Time PCR analysis was used to assess the expression of androgen regulatory protein (Andpro) and pyruvate dehydrogenase kinase 4 (Pdk4) genes in ED. For this purpose, the experiment was performed on 20 men with severe ED and 20 potent men. IIEF-15 was used to determine the ED severity. The study was conducted in the Department of Sexual Medicine of the Kermanshah University of Medical Sciences, Kermanshah, Iran. The EDTA-Na vacuum blood tube was taken from ED patients and controls. Informed consent was obtained from all participants. After blood sampling, RNA was extracted from whole blood. Then cDNA was synthesized. The gene expression was analyzed through the qPCR method. The ß-actin was used as a reference gene. To further study these two proteins, their three-dimensional structures were predicted through I-TASSER. Compared with controls, in ED patients, the expression of the Andpro gene decreased, while the expression of the Pdk4 gene increased (p<0.01). Predicting the structure of the protein showed that Pyruvate Dehydrogenase Kinase 4 had a double subunit and androgen-regulated protein had a single subunit.

Sexual Disorder in Men and Its Therapy with the Use of Phosphodiesterase Inhibitor Type 5 Eroton (Sildenafil Citrate)

The study investigated the clinical efficacy of the drug Eroton in the treatment of sexual disorders, shows the effect of the study drug on the state of the sexual functions of patients; the degree of patient satisfaction with treatment was assessed; studied the tolerability and possible side effects of the study drug in men in a group of 110 patients. After a course of one month of treatment, all the integrative indicators of ICEF significantly increased in patients. The indicator «erectile function» increased from 12.54±0.87 to 25.12±1.32 (p&lt;0,01), «satisfaction with intercourse» from 7.97±0.40 to 14.63±0.84 (p&lt;0,01), «orgasm» – from 4.52±0.18 to 9.02±0.32 (p&lt;0.01), «general satisfaction» – from 4.03±0.22 up to 8.27±0.46 (p&lt;0,01).&#x0D; The clinical efficacy of the treatment of erectile dysfunction showed «excellent» and «good» results in 92.7 % of patients. When studying the effect of the drug Eroton on the hormonal background in patients, there is a certain tendency to an increase in the content of testosterone in the serum of peripheral blood. This, from our point of view, is due to an improvement in the quality of sex life and an increase in its frequency. The indicator of «sex drive» of the ICEF questionnaire increased by 63.2 %. Improvement of the data on the ejaculatory component of sexual intercourse, which was assessed by the indicator of premature ejaculation in 61 men with this pathology, the clinical effectiveness of the course of treatment was 88.5 %. The time of the refractory period of sexual intercourse in patients decreased, which made it possible to carry out repeated sexual intercourse during the day in 34.5 % at the age of 22 to 34 years, and in 11.8 % of patients aged 22–29 years, 3 sexual intercourses were performed during the day. The frequency of sexual activity in patients with ED increased 2.1–2.4 times, and the quality of life index improved 3.8 times.&#x0D; Patients well tolerated treatment with Eroton. The drug Eroton can be considered as a first-line drug in the treatment of erectile dysfunction.

Analysis of Sexual Disorders in Men with Infrarenal Abdominal Aortic Aneurysm Treated by Stent-Graft or Prosthesis Implantation-A Pilot Study.

Background and objectives: Patients with obstruction or stenosis of the aorta and iliac arteries or with aortic aneurysm, often co-existing with iliac artery aneurysms, suffer from sexual disorders because of insufficient perfusion to the pelvic organs and penis. This is often the cause of visits to a medical doctor’s office with reports of a difficult life situation and a problem with the satisfactory completion of sexual intercourse. A low percentage of vascular surgeons or angiologists are prepared to talk about issues related to the hereditary sphere with a patient who qualifies for the treatment of Leriche syndrome or abdominal aortic aneurysm. The aim of this study was to analyze sexual disorders in men with infrarenal abdominal aortic aneurysm treated by stent-graft or prosthesis implantation. Material and methods, Outcomes: 38 patients who completed the IIEF-5 (International Index of Erectile for Men) questionnaire are presented. Initially, 146 qualified for the study after meeting the study inclusion criteria for surgery (Group 1) or for endovascular treatment of abdominal aortic aneurysm (Group 2). Results: In the study, no negative impact of smoking was found; however, over 95% of respondents had been smoking for many years in both groups. Patients who qualified for vascular prosthesis implantation were subject to a more advanced atherosclerotic process involving the aorta and iliac arteries. Patients who qualified for stent-graft implantation were twice as often treated for coronary vessel stenosis. In Group 1, the percentage differences, as shown by questions 1 and 5, were statistically significant (58, i.e., 25%, and 40, i.e., 29%). Conclusions: Education should target medical personnel in terms of conversations with patients, as well as men who are directly affected by this problem, although their partners and families should not be neglected in these activities. The ability to communicate properly allows for an open dialogue on issues that the patient finds difficult, particularly in the field of sexology.

The heart rate recovery is impaired in participants with premature ejaculation.

Premature ejaculation (PE) is one of the most common sexual disorders in men. Excessive activity of the sympathetic nervous system is considered as one of the pathological mechanisms of PE. Heart rate recovery (HRR) is a noninvasive and easily applicable method for evaluating autonomic functions. We aimed to investigate the relationship between PE and HRR. This cross-sectional study included 42 consecutive patients with lifelong PE and 98 healthy volunteers. All participants underwent stress tests according to age-dependent target heart rates outlined in the Bruce protocol. When the maximal heart rate was reached in the stress test, intensive exercise was terminated and electrocardiographic records were obtained for 3min in the cool-down period. The HRR indices were calculated by subtracting the heart rate at first, second and third minutes from the maximal HR. The two groups were similar in terms of age, body mass index, serum glucose and lipid parameters. HRR indices were significantly lower in the PE group compared with the control group (p<.05 for all). Common factors that affect equilibrium of sympathetic and parasympathetic nervous systems may be involved in the PE and abnormal HRR etiopathogenesis. The cause-and-effect relationship can be more clearly demonstrated with large-scale, prospective studies.