You have accessJournal of UrologySexual Function/Dysfunction: Evaluation I (MP27)1 Sep 2021MP27-01 IMPACTS OF NEOADJUVANT HORMONAL THERAPY PRIOR TO ROBOT-ASSISTED RADICAL PROSTATECTOMY ON POSTOPERATIVE HORMONAL- AND SEXUAL-RELATED QUALITY OF LIFE—ASSESSMENT BY PATIENT-REPORTED QUESTIONNAIRE Soichiro Ogawa, Kei Yaginuma, Akihisa Hasegawa, Syunta Makabe, Yuki Harigane, Yu Endo, Hitomi Imai, Yuta Matsuoka, Satoru Meguro, Ryo Tanji, Akifumi Onagi, Ruriko Honda-Takinami, Kanako Matsuoka, Seiji Hoshi, Tomoyuki Koguchi, Emina Kayama, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, and Yoshiyuki Kojima Soichiro OgawaSoichiro Ogawa More articles by this author , Kei YaginumaKei Yaginuma More articles by this author , Akihisa HasegawaAkihisa Hasegawa More articles by this author , Syunta MakabeSyunta Makabe More articles by this author , Yuki HariganeYuki Harigane More articles by this author , Yu EndoYu Endo More articles by this author , Hitomi ImaiHitomi Imai More articles by this author , Yuta MatsuokaYuta Matsuoka More articles by this author , Satoru MeguroSatoru Meguro More articles by this author , Ryo TanjiRyo Tanji More articles by this author , Akifumi OnagiAkifumi Onagi More articles by this author , Ruriko Honda-TakinamiRuriko Honda-Takinami More articles by this author , Kanako MatsuokaKanako Matsuoka More articles by this author , Seiji HoshiSeiji Hoshi More articles by this author , Tomoyuki KoguchiTomoyuki Koguchi More articles by this author , Emina KayamaEmina Kayama More articles by this author , Junya HataJunya Hata More articles by this author , Yuichi SatoYuichi Sato More articles by this author , Hidenori AkaihataHidenori Akaihata More articles by this author , Masao KataokaMasao Kataoka More articles by this author , and Yoshiyuki KojimaYoshiyuki Kojima More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002024.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Neoadjuvant hormonal therapy (NHT) before radical prostatectomy (RP) is not recommended in current guidelines. Despite this recommendation, NHT before RP is sometimes conducted for a small portion of patients in a clinical practice. Not just side effects of hormonal therapy, degenerate postoperative quality life (QOL) remains the major problem even in the era of robot-assisted RP (RARP). In this study, we evaluated the impacts of NHT on hormonal- and sexual- related QOL in patients who underwent RARP. METHODS: A total of 470 patients were enrolled. According to whether NHT was administered at least one time, patients were divided into two groups, the non-NHT group (n=408) and the NHT group (n=62). Hormonal- and sexual-related QOL was measured with the Japanese version of Expanded Prostate Index Composite (EPIC) questionnaire. RESULTS: Hormonal summary scores at 6, 9 months (p=0.002 and 0.017, respectively), function scores before and 3, 6, 9 months after RARP (p=0.005, 0.031, 0.0009 and 0.008, respectively) and bother score at 6 months (p=0.025) in NHT group were statistically lower than those of non-NHT group. Decreased sexual function scores in NHT group was observed before and 6 months after RARP (p=0.027 and 0.021, respectively). Sexual function at 3 months in patients with >5 month-NTH duration significantly worse than that of ≤5 months (p=0.047). On the contrary, significantly worse sexual bother at 3 months was observed in patients with ≤5 month-NHT duration than that of >5 months (p=0.032). All of hormonal and sexual scores were not statistically significant between patients treated with anti-androgen monotherapy and luteinizing hormone-releasing hormone (LH-RH) agonists with/without anti-androgen drugs. CONCLUSIONS: NHT prior to RARP should not be recommended in terms of not only oncological outcome but also the impacts on postoperative hormonal- and sexual-related QOL. Source of Funding: None of the authors has any relevant financial interests, relationships, activities or affiliations pertaining to this study © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e472-e472 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Soichiro Ogawa More articles by this author Kei Yaginuma More articles by this author Akihisa Hasegawa More articles by this author Syunta Makabe More articles by this author Yuki Harigane More articles by this author Yu Endo More articles by this author Hitomi Imai More articles by this author Yuta Matsuoka More articles by this author Satoru Meguro More articles by this author Ryo Tanji More articles by this author Akifumi Onagi More articles by this author Ruriko Honda-Takinami More articles by this author Kanako Matsuoka More articles by this author Seiji Hoshi More articles by this author Tomoyuki Koguchi More articles by this author Emina Kayama More articles by this author Junya Hata More articles by this author Yuichi Sato More articles by this author Hidenori Akaihata More articles by this author Masao Kataoka More articles by this author Yoshiyuki Kojima More articles by this author Expand All Advertisement Loading ...