Gonorrhea is a sexually transmitted infection (STI) that occurs most frequently throughout the world every year and is the second most common infection caused by bacteria. This study aimed to analyze the risk factors including education, employment, marital status, alcohol consumption status, sexual practices history, condom use behavior, and the most dominant risk factors for the incidence of sexually transmitted infections (STIs) of Gonorrhea in male patients at the Hitam Putih Clinic in Gorontalo. The research design employed was an analytical observational approach with a case-control design. The sample in this study comprised 33 male patients with gonorrhea and 66 male control patients with non-gonorrhea, matched based on patients’ age. Data were analyzed using Odds Ratio (OR) with a 95% Confidence Interval (CI) in the Mantel-Haenszel test. If the OR value was > 1 and the p-value was ≤ α (0.05), it meant that the factor increased the risk. Factors include educational background (OR=1.963; p=0.120), employment status (OR=3.077; p=0.01), marital status (OR=2.870; p=0.02), alcohol consumption status (OR=4.080; p =0.03), sexual practices history (OR=21.350; p=0.000), condom use behavior (OR=4.389; p=0.007) were risk factors for gonorrhea, where sexual practices history (OR=35.704; p=0.000) stood out as the most dominant risk factor. Therefore, those variables represented significant risk factors for the occurrence of Gonorrhea among male patients in the Hitam Putih Clinic in Gorontalo. Educational background, employment status, marital status, alcohol consumption status, sexual practices history, and condom use behavior are the risk factors of gonorrhea where the sexual practices history stands out as the most dominant risk factor.