Even though the struggle to achieve food security at the household level in the rural areas of Ethiopia dates back a long period, it has remained as a challenging goal even today. Making their living on marginal, moisture stressed, heavily degraded and less productive land, households in rural areas of Dire Dawa face persistent food shortages. The design and implementation of effective measures to reduce household food insecurity in the region depends on in-depth understanding of its covariates. This study seeks to address these issues by assessing location specific socio-economic factors that influence food insecurity of households in rural areas of Dire Dawa Administrative region. The analysis is based on survey data gathered from randomly selected 115 sample rural households in the study area. A binary logit model was used to identify the factors influencing household level food insecurity. A total of thirteen explanatory variables were included in the empirical model. The empirical results estimated using the survey data to identify the determinants of food insecurity among rural households in the study area revealed mixed impressions. Among variables considered , family size, annual income, amount of credit received, access to irrigation, age of household head, farm size, and livestock owned showed theoretically consistent and statistically significant effect. However, estimated coefficients of number of oxen owned and dependency ratio showed theoretically inconsistent and statistically insignificant effect on the probability of household to be food insecure.. Estimated coefficients of sex of household head, total off-farm income, education of household head and amount of food aid received were not found to be statistically significant in determining household food insecurity in the study area. The findings imply that improvement in food security situation needs to build assets, improve the functioning of rural financial markets and promote family planning. These areas could provide entry points for policy intervention to reduce hunger and augment household and community livelihood opportunities.