Severe Carbon Monoxide Poisoning Research Articles

Cutaneous blisters and carbon monoxide poisoning

We present the cases of three patients with skin blisters following carbon monoxide (CO) poisoning. Their blisters appeared to be related to the severity of the poisoning (HbCO levels of more than 40%). Two of the three patients died despite aggressive initial 100% surface oxygen followed by hyperbaric oxygen therapy. The pathophysiology of this type of blister remains unresolved. It could result from pressure necrosis alone or from a combination of pressure necrosis and direct CO inhibition of tissue oxidative enzymes. Although skin involvement as a result of CO poisoning is less frequently reported today than in the past (perhaps because of misidentified burns or because of more aggressive resuscitation and treatment protocols), the physician should recognize that such blisters may signal severe CO poisoning.

Chemical pulmonary burn injury and chemical intoxication.

Two large groups of patients with chemical pulmonary burns who sustained their injuries in the same environment were presented. Data from the blaze smoke analysis of two imitative experiments which were performed under the same conditions as were present when these patients sustained their burns showed a high concentration of carbon monoxide of 35700-571400 ppm and multivariable components of chemicals. The environmental conditions, the clinical course, laboratory findings and blaze analysis clearly demonstrated the close relationship between chemical pulmonary burn injury and chemical intoxication which increased the difficulty in treatment. Ideally, the initial treatment at the site of the fire is the application of 100 per cent oxygen in high flow by mask, and temporary artificial hyperventilation after hospitalization will give a satisfactory result if the fire victim suffers severe carbon monoxide poisoning. In order to treat chemical intoxication in the patient with chemical pulmonary burns successfully, we have adopted a regimen of 'over-loading fluid resuscitation', together with diuretics and positive end expiratory pressure (PEEP) under the monitoring of central venous pressure.

Carbon Monoxide Poisoning in Fire Victims

In victims of carbon monoxide (CO) poisoning, metabolic acidosis has been considered a clinical finding of ominous prognostic importance. In previous studies, such patients either died or suffered serious neurologic sequelae, resulting in the recommendation by some authors that these patients require more complicated therapy, including hyperbaric oxygen and hypothermia. This report documents the full neurologic recovery of three patients with severe metabolic acidosis and CO poisoning. Our experience indicates that acidosis may not be as important a prognostic factor as previously thought, and that randomized prospective trials are needed in such patients before more complicated therapy becomes accepted medical practice.

Treatment of carbon monoxide poisoning by mechanical ventilation: case report.

Severe carbon monoxide poisoning is a not uncommon disease in North America. The authors were privileged to treat a fifteen-year-old female who had attempted suicide with carbon monoxide. When first seen, she exhibited decerebrate rigidity and evidence of aspiration pneumonitis. She was treated with prolonged tracheal intubation and moderate hyperventilation. She also received dexamethasone as an anti-oedema and anti-inflammatory agent. The patient “awoke” after sixty hours of ventilator therapy. She subsequently recovered from most of her neurologic injuries. She is said to be the first survivor (in this area) of carbon monoxide poisoning with decerebrate rigidity.

Hypothermia -- its use in severe carbon monoxide poisoning.

CLINICAL hypothermia has been used recently, with success, in a wide variety of conditions having in common Central-nervous-system hypoxia and edema. Reports have appeared in the literature regardi...

Resuscitation of dogs from severe acute carbon monoxide poisoning.

The Journal of PhysiologyVolume 147, Issue 2 p. 274-298 ArticleFree Access Resuscitation of dogs from severe acute carbon monoxide poisoning Esther M. Killick, Esther M. KillickSearch for more papers by this authorJean V. Marchant, Jean V. MarchantSearch for more papers by this author Esther M. Killick, Esther M. KillickSearch for more papers by this authorJean V. Marchant, Jean V. MarchantSearch for more papers by this author First published: 02 September 1959 https://doi.org/10.1113/jphysiol.1959.sp006243Citations: 19AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume147, Issue2September 2, 1959Pages 274-298 RelatedInformation