Severe Wind Research Articles

Influence of endotracheal tube and laryngeal mask airway for general anesthesia on perioperative adverse events in patients undergoing laparoscopic hysterectomy: A propensity score-matched analysis.

To compare perioperative adverse events between general anesthesia with endotracheal tube (ETT) and general anesthesia with laryngeal mask airway (LMA) in patients undergoing laparoscopic hysterectomy. This was a large sample retrospective, propensity score-matched (PSM) study. We collected the data of 6739 female patients who underwent laparoscopic hysterectomy between January 2016 and June 2021 in our hospital, China. Patients were divided into two groups (ETT group and LMA group) according to different airway management modes. Data on all perioperative adverse events were collected. PSM analysis was performed to control confounding factors and differences in baseline values between the two groups. Finally, 4150 female patients were recruited after PSM. The total number of patients taking intraoperative vasoactive drugs during surgery was higher in the ETT group than in the LMA group (P = 0.04). The LMA group had a higher incidence of vomiting (51 [2.46%]) and somnolence (165 [7.95]) in the postanesthesia care unit (PACU) than the ETT group (71 [3.42%] and 102 [4.92%], respectively) (P = 0.02 and P < 0.001). Hypothermia was significantly higher in the LMA group (183 [10.36%]) than in the ETT group (173 [8.34%]) in the PACU (P = 0.03). The number of patients with sore throat was significantly higher in the ETT group (434 [20.02%]) than in the LMA group (299 [14.41%]) in the ward (P < 0.001). Other variables such as hypoxemia, moderate to severe pain, abdominal distension, diarrhea, sleep disorders, wound bleeding, and skin itch were not significantly different between the two groups (P > 0.05). The ETT group had more incidences of vomiting, sore throat, and cough complications and needed more drug treatment than the LMA group. LMA is a better airway management mode and LMA general anesthesia can be safely used in patients undergoing laparoscopic nonemergency hysterectomy.

ALT Free Flap Coverage after Carotid Endarterectomy in the Setting of Severe Radiation Changes

Summary: Carotid endarterectomy with patch angioplasty is commonly performed for severe atherosclerotic disease to reduce stroke risk. After neck radiation, loss of tissue planes; reactive fibrosis of skin; contraction; and rarely, necrosis of skin may occur, leading to severe wound complications and possible exposure of carotid artery reconstruction. Historically, local myocutaneous flaps have been performed to provide soft tissue coverage; however, these procedures may be associated with increased donor site morbidity and can be affected by radiation changes. This report describes the novel use of a fasciocutaneous free flap for durable vascularized soft tissue, and the associated secondary benefit of improved suppleness and range of motion. Additionally, the distant location of the donor site allows for an efficient two-team approach. Here, we describe a patient with severe carotid artery disease with a history of multiple surgical procedures and radiation, which was successfully treated with a carotid endarterectomy and bovine patch angioplasty by vascular surgery and immediate free anterolateral thigh flap coverage by our team.

Abundance, distribution and deposition of PM2.5-bound iron in northern China during 2021 dust and dust storm periods

Dust storms have the ability to transport and deposit contaminants and nutrients, such as iron (Fe), to downwind regions through atmospheric processes. However, there is a lack of reported data on the high-resolution variations and deposition of particulate iron in multiple locations during dust storms. This study aimed to address this gap by employing standardized analytical methods to measure the concentrations of PM10, PM2.5, and PM2.5-associated Fe in Taiyuan, Beijing, Tianjin, Ji'nan, and the Bohai Bay of China during the dusty events of 2021. A total of 13 blowing sand or dust storms were recorded, with average PM10 and PM2.5 concentrations of 262 ± 322 and 85 ± 652, 171 ± 403 and 53 ± 448, 153 ± 211 and 57 ± 315, and 207 ± 249 and 63 ± 301 μg/m3 at the above-mentioned sites, respectively. These elevated concentrations were attributed to stronger winds in northern China and severe wind erosion in the sand source areas. During these events, the average concentrations of PM2.5-bound Fe reached 2730.2 ± 4587.9, 2030.2 ± 3877.9, 1342.1 ± 2251.4, and 1785.1 ± 2536.6 ng/m3 in Taiyuan, Beijing, Tianjin, and Ji'nan, respectively, with the highest concentrations recorded as 48.8, 48.0, 29.2, and 22.7 μg/m3. A significant positive correlation was observed between Fe and Si in PM2.5 in the four cities, with higher Fe/Si slopes recorded in or near the source regions, while the homogenized Fe/Si values were observed after long-distance transport. The mean dry deposition fluxes (FFe) of PM2.5-bound Fe were calculated as 0.34 ± 0.64, 0.31 ± 0.91, 0.21 ± 0.56, and 0.17 ± 0.28 mg/m2/d for Taiyuan, Beijing, Tianjin, and Ji'nan, respectively, based on both hourly observation data and model-based calculations of dry deposition velocities. It is worth noting that FFe decreased from west to east in China, consistent with a previous study that showed a decrease in dust deposition rates with increasing transport distances. Peaks in FFe corresponded to the highest concentrations of PM2.5-associated Fe, indicating that these concentrations played a significant role in Fe. Furthermore, the atmospheric deposition of dissolved Fe from blowing sand or dust storm events was found to contribute to carbon fixation in the Bohai region of China, providing a range of 7.8 × 104–3.9 × 106 mol. This research provides valuable insights into the quantitative relationship between atmospheric deposition and marine productivity during dust events.

Effects of virtual reality on pain during intrauterine device insertions: A randomized controlled trial

ObjectivesThe trial aimed to compare the pain perceived by women during intrauterine device (IUD) insertion, with or without virtual reality (VR) therapy. Furthermore, anxiety during the insertions, pain after the insertions, and satisfaction with the insertions were compared. MethodsThe trial was designed as a prospective, bi-centric, randomized, open-label interventional trial. All adult women that chose an IUD during a contraceptive consultation, and who provided informed consent were eligible. Women under legal guardianship, not affiliated to a national social security system, and with pre-existing dizziness, severe facial wounds, or epilepsy were not eligible. Eligible women were randomly allocated either standard care without VR therapy (Control group) or with VR therapy (Experimental group). Pain, anxiety, and satisfaction were measured using a 10-cm numerical scale. ResultsBetween September 2020 and April 2022, 100 women were randomized: 50 to each group. The mean pain scores during IUD insertion were 5.4 cm in the Control group versus 5.1 cm in the Experimental group (p = 0.54). Mean anxiety during insertion were 4.8 cm in the Control group versus 4.2 cm in the Experimental group (p = 0.13). While mean pain perceived after insertions were 2.4 cm in the Control Group and 2.4 cm in the Experimental group (p = 0.98). Mean satisfaction with the insertions was 9.6 cm in both groups (p = 0.87). Anxiety before IUD insertion, as well as anticipated pain, were significantly correlated with pain perceived during insertions. ConclusionsVR therapy performed during the procedure did not alleviate perceived pain in women undergoing IUD insertions.

Nursing discharge teaching of hospitalized postpartum women in China: A cross-sectional study

BackgroundPostpartum women encounter a diverse array of physiological challenges following childbirth, and they may also contend with issues such as a lack of self-care knowledge childcare knowledge, and childcare experience. This study aimed to explore the quality of discharge teaching for hospitalized postpartum women. MethodsA total of 292 parturients who gave birth in a tertiary hospital were selected using the convenience sampling method and surveyed using a general data questionnaire and discharge teaching quality scale. ResultsThe total score for the quality of discharge teaching was 111.95 ​± ​28.64. In bivariate analysis, significant differences were identified between postpartum women with differences in postpartum complications, ambulation time, wound pain, infant health status, and infant feeding methods (p ​< ​0.05). Wound pain and infant feeding methods were significant factors in a multiple linear regression model (p ​< ​0.05). ConclusionsNursing staff should focus on psychological nursing care and give more personalized teaching to postpartum women with severe wound pain and who bottle feed their newborns.

Predictors of death in seriously injured patients

The purpose of the study. To analyze the structure of the incoming flow in conditions of conducting large-scale military operations at the stage of emergency specialized surgical care and to determine the predictors of an unfavorable outcome in patients with severe combined wounds. Materials and methods. A retrospective cohort study of medical data was performed in seriously wounded during a special military operation who were admitted to the department of anesthesiology, intensive care and intensive care of a level 3 military medical organization with severe combined wounds and trauma in 45 seriously wounded. Depending on the outcome of treatment, the seriously injured and injured were divided into 2 groups: survivors (n=30, 66.6%) and deceased (n=15, 33.4%) within a 30-day period from the moment of injury. Results. In the structure of seriously injured people in need of resuscitation, gunshot wounds predominate 84.5% (fragmentation — 95.4%, bullet — 4.6%), surgical diseases account for 7.2% of cases, closed trauma occurs in 5.1% of cases, thermal lesions — 3.2%. Combined and multiple wounds were diagnosed in 96.2% of cases. Upon admission, the predictors of death are hypothermia (p-value=0.011), the time elapsed from injury to qualified surgical care (p-value=0.035), the severity of the condition on the APACHE II scale (p-value=0.047). During treatment at the stage of emergency specialized surgical care, the predictors of death are the laboratory assessment of total bilirubin (p-value=0.006), the SOFA scale (p-value=0.015), an increase in creatinine levels (p-value=0.018), the appearance of metabolic acidosis (p=0.022), an increase in the dose of norepinephrine (p-value=0.015).value=0.033), as well as an increase in potassium levels (p-value=0.041). Conclusion. The result of the study showed a high frequency of combined injuries admitted to the OARIT. The predictors of an unfavorable outcome at admission were hypothermia; the time elapsed from the moment of injury to the provision of qualified surgical care; the severity of the condition on the APACHE II scale. And during intensive therapy, the predictors were: an assessment on the SOFA scale, an increase in creatinine levels, total bilirubin, potassium levels and metabolic acidosis.

Hyaluronic Acid-Based Reactive Oxygen Species-Responsive Multifunctional Injectable Hydrogel Platform Accelerating Diabetic Wound Healing.

Diabetic wounds are more likely to develop into complex and severe chronic wounds. The objective of this study is to develop and assess a reactive oxygen species (ROS)-responsive multifunctional injectable hydrogel for the purpose of diabetic wound healing. A multifunctional hydrogel (HA@Cur@Ag) is successfully synthesized with dual antioxidant, antibacterial, and anti-inflammatory properties by crosslinking thiol hyaluronic acid (SH-HA) and disulfide-bonded hyperbranched polyethylene glycol (HB-PBHE) through Michael addition; while, incorporating curcumin liposomes and silver nanoparticles (AgNPs). The HA@Cur@Ag hydrogel exhibits favorable biocompatibility, degradability, and injectivity. The outcomes of in vitro and in vivo experiments demonstrate that the hydrogel can effectively be loaded with and release curcumin liposomes, as well as silver ions, thereby facilitating diabetic wound healing through multiple mechanisms, including ROS scavenging, bactericidal activity, anti-inflammatory effects, and the promotion of angiogenesis. Transcriptome sequencing reveals that the HA@Cur@Ag hydrogel effectively suppresses the activation of the tumour necrosis factor (TNF)/nuclear factor κB (NF-κB) pathway to ameliorate oxidative stress and inflammation in diabetic wounds. These findings suggest that this ROS-responsive multifunctional injectable hydrogel, which possesses the ability to precisely coordinate and integrate intricate biological and molecular processes involved in wound healing, exhibits notable potential for expediting diabetic wound healing.

Recessive dystrophic epidermolysis bullosa caused by a novel COL7A1 variant with isodisomy

Recessive dystrophic epidermolysis bullosa is a genetic collagen disorder characterized by skin fragility that leads to generalized severe blistering, wounds, and scarring. In this report, we present a patient with a novel COL7A1 homozygous nonsense variant, c.793C>T p.(Gln265*). Although the parents were not consanguineous, both were heterozygous carriers of the variant. Single nucleotide polymorphism (SNP) array analysis revealed an isodisomy area on 3p22.1p21.1, encompassing COL7A1, suggesting that the variant originated from a common ancestor.

Life cycle carbon footprint accounting of an offshore wind farm in Southeast China—Simplified models and carbon benchmarks for typhoons

Offshore wind farms are fast-spreading off the southeast coast of China to achieve carbon neutrality by 2060. However, unfavorable weather conditions in Southeast China (e.g. frequent typhoons and severe wind intermittency) may increase the carbon footprint of offshore wind energy. But typhoons have never been considered in carbon accounting before, which may affect the design decisions of stakeholders and research priority setting for academicians. (i) To determine the effect of typhoons on carbon footprint, a life cycle assessment was performed on a typical offshore wind farm using real data. The results demonstrate that typhoons can be the largest contributor to carbon footprint, and the maximum wind speed of typhoons is the most critical parameter to carbon footprint. (ii) To quantify the carbon emissions caused by typhoons, simplified models estimating carbon emission intensity under different maximum wind speeds of typhoons are established, using Monte Carlo method based on 51 historical typhoons. The models imply that wind turbines with Permanent Magnet Synchronous Generator (PMSG) are highly recommended in typhoon-prone area, because their carbon footprint is smaller than those with Doubly-Fed Induction Generator (DFIG). (iii) To set carbon benchmarks for typhoons, statistic analysis was conducted based on the simulated samples generated by Monte Carlo method. The carbon benchmarks of typhoons show that gearbox has the highest carbon emission intensity (mean=4.35g/kW, 95th percentile=7.00g/kW) among all components, resulting DFIG with gearbox not suitable in typhoon-areas. The site selection of offshore wind farms in Southeast China should avoid areas where the maximum wind speed of typhoons exceeds 44.5 m/s. This study emphasizes the importance of typhoons in carbon footprint accounting for offshore wind farms in Southeast China. More significantly, the proposed simplified models and carbon benchmarks of typhoons can be applied to feasibility studies in early design stage for engineers and stakeholders.

Macrophage metabolism reprogramming EGCG-Cu coordination capsules delivered in polyzwitterionic hydrogel for burn wound healing and regeneration.

Excessive reactive oxygen species (ROS) at severe burn injury sites may promote metabolic reprogramming of macrophages to induce a deteriorative and uncontrolled inflammation cycle, leading to delayed wound healing and regeneration. Here, a novel bioactive, anti-fouling, flexible polyzwitterionic hydrogel encapsulated with epigallocatechin gallate (EGCG)-copper (Cu) capsules (termed as EGCG-Cu@CBgel) is engineered for burn wound management, which is dedicated to synergistically exerting ROS-scavenging, immune metabolic regulation and pro-angiogenic effects. EGCG-Cu@CBgel can scavenge ROS to normalize intracellular redox homeostasis, effectively relieving oxidative damages and blocking proinflammatory signal transduction. Importantly, EGCG-Cu can inhibit the activity of hexokinase and phosphofructokinase, alleviate accumulation of pyruvate and convert it to acetyl coenzyme A (CoA), whereby inhibits glycolysis and normalizes tricarboxylic acid (TCA) cycle. Additionally, metabolic reprogramming of macrophages by EGCG-Cu downregulates M1-type polarization and the expression of proinflammatory cytokines both in vitro and in vivo. Meanwhile, copper ions (Cu2+) released from the hydrogel facilitate angiogenesis. EGCG-Cu@CBgel significantly accelerates the healing of severe burn wound via promoting wound closure, weakening tissue-damaging inflammatory responses and enhancing the remodeling of pathological structure. Overall, this study demonstrates the great potential of bioactive hydrogel dressing in treating burn wounds without unnecessary secondary damage to newly formed skin, and highlights the importance of immunometabolism modulation in tissue repair and regeneration.

Sprayable ciprofloxacin-loaded poloxamer hydrogels for wound infection treatment.

Topical antimicrobial treatments for severe burns and chronic wounds provide effective treatment against infections, but cause pain and discomfort with application. This study aimed to develop an antimicrobial topical formulation comprising thermoreversible poloxamers (Pluronic F127 and F68) and a broad-spectrum antimicrobial agent (ciprofloxacin hydrochloride, CH), that could be sprayed to eliminate application pain while maintaining antimicrobial activity. Formulations were characterized to determine their sprayability under cold conditions, gelation temperature, final storage modulus at skin temperature, drug release profile, ex vivo permeation through impaired porcine skin, and inhibition against common bacterial pathogens that colonize wounds. All cold formulations were sprayable from simple hand-held, pump-action sprayers due to their low viscosity. Upon heating, 17 and 20% Pluronic F127 formulations produced hydrogels eight to ten degrees below skin temperature, independent of ciprofloxacin loading. Increasing concentrations of Pluronic F127 increased the final storage modulus and viscosity of the gels, while inclusion of Pluronic F68 reduced these properties, showing that hydrogel rheological properties at skin temperature can be tuned via choice of formulation. Drug release was directly correlated to the rheological properties, with stiffer gels resulting in a decrease in drug release rate. Overall, gels released about 65-90% of their load within 12 hours. Ex vivo skin permeation demonstrated that drug was well retained in impaired porcine skin, which is desired to continuously treat bacteria localized to the wound. A well-diffusion assay indicated that the hydrogels had greater bacterial inhibition against Pseudomonas aeruginosa, Escherichia coli, and two strains of Staphylococcus aureus when compared to commercial controls. Overall, the results show the potential of CH-loaded poloxamer formulations as suitable sprayable topical dressings to deliver antimicrobials directly to wounds.

Imaging findings of the injured in the massive Beirut blast.

(1) Describe imaging utilization and findings within two weeks of the 2020 Beirut blast according to the mechanism of injury, (2) determine the appropriate imaging modality per organ/system, and (3) describe changes in the workflow of a radiology department to deal with massive crises. Two hundred sixty patients presented to the largest emergency department in Beirut and underwent imaging within 2 weeks of the blast. In this retrospective study, patients were divided into early (1) and late (2) imaging groups. Patients' demographic, outcome, type and time of imaging studies, body parts imaged, and mechanism and types of injuries were documented. Two hundred five patients in group 1 underwent 502 and 55 patients in group 2 underwent 145 imaging studies. Tertiary blast injuries from direct impact and falling objects were the most common type of injuries followed by secondary (shrapnel) injuries. Both types of injuries affected mostly the head and neck and upper extremities. Plain radiographs were adequate for the extremities and CT for the head and neck. A regularly updated and practiced emergency plan is essential to mobilize staff and equipment and efficiently deliver radiology services during crises. Because the powerful Beirut blast occurred at the port located in the periphery of the city, most injuries seen on imaging were of the upper extremities and head and neck caused by the severe blast wind or penetrating shrapnel and resulted from people using their arms to protect their heads and bodies from direct impact and falling objects.

Nutrition Considerations for Burn Patients: Optimizing Recovery and Healing

The hypermetabolic and hypercatabolic responses to severe burns put nutrition support at the forefront of treatments. When left untreated, severe weight loss, increased infection, and wound healing failure can occur. Enteral nutrition is the primary method of nutrition support in such patients. Meeting caloric needs and a positive nitrogen balance are short-term goals of nutrition support, with long-term goals of minimizing lean body mass loss and maximizing wound healing. High-carbohydrate and low-fat nutrition received evidence from randomized controlled trials of aiding in decreasing pneumonia rates and was found to promote positive nitrogen balance, which lipids do not do. We go through the macronutrient and micronutrient needs of the burn patient as well as techniques for meeting these needs in the modern intensive care unit, with some discussion of alterations in these techniques that are required in the austere environment.

Shape-adapted self-gelation hydrogel powder for high-performance hemostasis and wound healing

In the battlefield, accidents, first aid, and hospital environments, uncontrollable bleeding caused by severe wound infections pose a serious risk of death and high costs. However, performing ultrafast hemostasis without any external conditions remains challenging. In this paper, polyacrylic acid, polyacrylamide, tea polyphenols, and Yunnan Baiyao (PAA/PAAm/T/YNBY, PPTY) are used to prepare self-gelling powder with shape adaptability. When the mass fraction of PAA and PAAm is 10 wt% and 8 wt%, the hydrogel can form the most intermolecular hydrogen bonds, exhibiting the best adhesion ability and mechanical strength. When the amount of YNBY was 0.1 wt%, the hydrogel had the most suitable cellular compatibility and hemostatic ability. At this time, the hydrogel powder can achieve the fastest self-gelling (< 3 s), the strongest adhesion (interface adhesion > 499.4 N m − 1), and the fastest hemostatic speed (< 30 s). With the addition of a small amount of YNBY (0.1 wt%), the hemostatic efficiency of the hydrogel can be greatly improved. The combination of hydrogel and YNBY not only prolongs the duration of YNBY ingredient efficacy but also enhances its biocompatibility. This easy-to-use but effective hydrogel can stop bleeding, promote wound healing in emergencies, and has opportunities in functional materials, tissue engineering, biomedical engineering, and clinical medicine.

Wind erosion caused by the change of Chaiwopu lake on the northern foothill of Tianshan Mountain, based on SBAS-InSAR

In arid regions, terminal lakes play a crucial role in maintaining the local ecological environment. However, due to the impact of climate change and human activities, terminal lakes are prone to shrinkage and drying up. The exposed lakebeds became new sources of sand and dust, leading to severe land degradation. This study extracted the water surface area of the Chaiwopu Lake in Urumqi and calculated the fractional vegetation cover (FVC) in the surrounding areas based on Landsat images from 2000 to 2022. The changes in FVC and lake area before and after the implementation of the policies on fallow and groundwater extraction restriction in 2014 were analyzed. Using the SBAS-InSAR method, the surface deformation during the period of minimum lake area from 2014 to 2018 was estimated, and the process of wind erosion and accumulation in the dried lake basin was analyzed. The results showed that from 2011 to 2014, Chaiwopu Lake experienced rapid shrinkage, and the lake almost disappeared. After 2014, the lake rapidly recovered, reaching 70% of its original area by 2021. With the recovery of the lake, the vegetation coverage in the surrounding area has changed from decreasing to increasing. During the period of lake shrinkage, the dried lake basin experienced severe wind erosion, with the maximum erosion rate exceeding 40 mm/year. The sand and dust from the dried lake basin accumulated around the lake under the influence of wind, further accelerating land degradation in the surrounding areas. After 2021, the restored lake and wetland surface covered the once-dry lake basin again, and the largest dust source in the region nearly disappeared. The study results indicated that the restoration of the lake and surrounding vegetation can eliminate the sources of sand and dust and prevent their transportation, effectively preventing land desertification.

Towards improved short-term forecasting for Lake Victoria Basin: Part I – A radar-based convective mode analysis

Abstract East African countries benefit economically from the largest freshwater lake in Africa: Lake Victoria (LV). Around 30 million people live along its coastline and 5.4 million people subsist on its fishing industry. However, more than 1,000 fishermen die annually by high-wave conditions often produced by severe convective wind phenomena, which marks this lake one of the deadliest places in the world for hazardous weather impacts. The World Meteorological Organization launched the 3-year “HIGH impact Weather lAke sYstem” (HIGHWAY) project, with the main objective to reduce loss of lives and economic goods in the lake basin and improve the resilience of the local communities. The project conducted a field campaign in 2019 aiming to provide forecasters with high-resolution observations and to study the storm life cycle over the lake basin. The research discussed here used the S-band polarimetric Tanzania radar from the field campaign to investigate the diurnal cycle of the convective mode over the lake. We classified the lake storms occurring during the two wet seasons into six different convective modes and present their diurnal evolution, organization, and main radar-based attributes, thereby extending the knowledge of convection on the lake. The result is the creation of a “convection catalog for Lake Victoria,” using the operational forecast lake sectors, and defining the exact times for the different timeslots resulting from the HIGHWAY project for the marine forecast. This will inform methods to improve the marine operational forecasts for Lake Victoria, and to provide the basis for new Standard Operation Procedures (SOP) for severe weather surveillance and warning.

Long-Term Observational Characteristics of Different Severe Convective Wind Types around Australia

Abstract Regional understanding of severe surface winds produced by convective processes [severe convective winds (SCWs)] is important for decision-making in several areas of society, including weather forecasting and engineering design. Meteorological studies have demonstrated that SCWs can occur due to a number of different mesoscale and microscale processes, in a range of large-scale atmospheric environments. However, long-term observational studies of SCW characteristics often have not considered this diversity in physical processes, particularly in Australia. Here, a statistical clustering method is used to separate a large dataset of SCW events, measured by automatic weather stations around Australia, into three types, associated with strong background wind, steep lapse rate, and high moisture environments. These different types of SCWs are shown to have different seasonal and spatial variations in their occurrence, as well as different measured wind gust, lightning, and parent-storm characteristics. In addition, various convective diagnostics are tested in their ability to discriminate between measured SCW events and nonsevere events, with significant variations in skill between event types. Differences in environmental conditions and wind gust characteristics between event types suggests potentially different physical processes for SCW production. These findings are intended to improve regional understanding of severe wind characteristics, as well as environmental prediction of SCWs in weather and climate applications, by considering different event types. Significance Statement The purpose of this study is to improve regional understanding of different types of severe wind events in Australia, specifically those associated with atmospheric convection. We did this by constructing a dataset of 413 severe convective wind events, using weather station and radar data within 20 regions around Australia. We then split those events into three different types, based on the environmental conditions that they occur within. We found that each event type tends to occur at different times of the year and in different regions, while also having different wind gust and lightning characteristics. In addition, the atmospheric conditions that are helpful for prediction of severe wind events differs between each type. These results are intended to be useful for prediction of severe wind events associated with convection and assessing their variability, characteristics, and impacts, in both weather forecasting and climate analysis.

Discriminant Analysis for Severe Storm Environments in South-Central Brazil

Abstract Severe storms produce hazardous weather phenomena, such as large hail, damaging winds, and tornadoes. However, relationships between convective parameters and confirmed severe weather occurrences are poorly quantified in south-central Brazil. This study explores severe weather reports and measurements from newly available datasets. Hail, damaging wind, and tornado reports are sourced from the PREVOTS project from June 2018 to December 2021, while measurements of convectively induced wind gusts from 1996 to 2019 are obtained from METAR reports and from Brazil’s operational network of automated weather stations. Proximal convective parameters were computed from ERA5 reanalysis for these reports and used to perform a discriminant analysis using mixed-layer CAPE and deep-layer shear (DLS). Compared to other regions, thermodynamic parameters associated with severe weather episodes exhibit lower magnitudes in south-central Brazil. DLS displays better performance in distinguishing different types of hazardous weather, but does not discriminate well between distinct severity levels. To address the sensitivity of the discriminant analysis to distinct environmental regimes and hazard types, five different discriminants are assessed. These include discriminants for any severe storm, severe hail only, severe wind gust only, and all environments but broken into “high” and “low” CAPE regimes. The best performance of the discriminant analysis is found for the “high” CAPE regime, followed by the severe wind regime. All discriminants demonstrate that DLS plays a more important role in conditioning Brazilian severe storm environments than other regions, confirming the need to ensure that parameters and discriminants are tuned to local severe weather conditions.

A Novel Polyphenolic Hydrogels Therapeutic Strategy for Diabetic Wounds Repair

As we all know, diabetes patients greatly decrease their quality of life and increase their economic burden. Tissue regeneration in diabetic wounds is a worldwide clinical challenge due to immune, genetic, and environmental factors. Severe infectious wounds in diabetic patients can potentially result in sepsis even amputation. Hence, it is necessary to use a rapid treatment strategy for effective anti-infection with hydrogel materials. Polyphenol polymers may quickly suppress reactive oxygen species of chronic inflammation for diabetic wounds. However, the instability of polyphenols reduces the rate of wound healing, using a hydrogel carrier as a carrier can improve the stability of polyphenolic compounds and control their release to accelerate wound healing. This review elaborates on diabetic wound pathogenesis, the therapeutic effect of polyphenolic hydrogel, including its preparation and stability, and the construction of the diabetes model, which provides a reference for the clinical treatment of diabetes.

Successful treatment of a severe open wound in a raccoon dog (Nyctereutes procyonoides): antibiotic susceptibility testing supported

An adult raccoon dog with extensive, deep, and contaminated wounds on the right hip and multiple fractures was rescued. The open wound was managed daily by debridement and flushing for 3 weeks. Modified active drainage was then performed, and antibiotics administered according to the antibiotic susceptibility test. After 2 weeks, the exudate disappeared and the drain was removed. After monitoring for 1 month, the animal was released in to the wild. This case shows that even if infection remains, rapid wound repair is possible if appropriate antibiotic selection through regular examination and active drainage are combined.