P346 Short term dose tailoring of anti TNF-a therapy delivers useful clinical efficacy in Crohn’s disease patients with secondary loss of response S. Ghaly1 *, S. Costello2, L. Beswick3, A. Pudipeddi4, A. Agarwal2, A. Sechi5, B. Headon3, R. Prosser6, S. Connor5, I.C. Lawrance7, M. Sparrow3, P. Bampton6, A. Walsh4, J. Andrews2. 1St. Vincent’s Hospital, University of New South Wales, Department of Gastroenterology, Sydney, Australia, 2Royal Adelaide Hospital, Department of Gastroenterology, Adelaide, Australia, 3The Alfred Hospital, Department of Gastroenterology, Melbourne, Australia, 4St. Vincent’s Hospital, Department of Gastroenterology, Sydney, Australia, 5Liverpool Hospital, Department of Gastroenterology, Sydney, Australia, 6Flinders Medical Centre, Department of Gastroenterology, Adelaide, Australia, 7Fremantle Hospital, Centre for Inflammatory Bowel Disease, Fremantle, Australia