<h3>Objective:</h3> POEMS is a rare and disabling paraneoplastic syndrome, with a plasma cell disorder background and a multisystem dysfunction. The acronym, first coined in 1980 by Bardwick, refers to polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. Not all of the features in this acronym are required to establish the diagnosis and other ones, not included in the name, are of utmost importance, such as elevated vascular endothelial growth factor (VEGF) levels, sclerotic bone lesions, extravascular volume overload, thrombocytosis and papilledema<sup>1</sup>. The diagnosis of POEMS syndrome is based upon the presence of the two mandatory major criteria (polyneuropathy and monoclonal gammopathy), at least 1 other major criteria (Castleman disease, sclerotic bone lesions and VEGF elevation) and at least 1 minor criteria (organomegaly, extravascular volume overload, endocrinopathy, skin changes, papilledema and thrombocytosis/polycythemia)<sup>2</sup>. <h3>Background:</h3> A 60-year-old man presented with a two-year history of severe neuropathic pain in limbs, distal weakness and hypoesthesia for pain and light touch. Due to a suspicion of a myeloradiculopathy, the patient underwent a cervical arthrodesis. On neurological examination there was distal muscular atrophy, a steppage gait, hyporeflexia in the lower limbs and allodynia in the feet. Complementary etiological investigation of neuropathy showed IgG lambda monoclonal gammopathy. MRI showed sclerotic bone lesion in the lumbosacral spine, and a mielography was compatible with plasma cell neoplasms. The patient began cyclophosphamide chemotherapy with significant improvement, and now waits for hematopoietic stem cell transplantation. <h3>Design/Methods:</h3> NA <h3>Results:</h3> NA <h3>Conclusions:</h3> The neuropathy is commonly the first clinical finding in POEMS and is usually demyelinating, sensory-motor, length-dependent and may be painful (65%). In this case report we reinforce not only the importance of a throughout clinical evaluation, but also an extensive etiologic investigation when facing neuropathies, as they can be the unique early manifestation of a serious treatable disorder, as POEMS syndrome. <b>Disclosure:</b> Rodrigo Queiroz has nothing to disclose. Dr. Pinheiro has nothing to disclose. Dr. Marques has nothing to disclose. Dr. Silva has nothing to disclose. Dr. Braune has nothing to disclose.