Severe Medical Emergency Research Articles

Higher Incidences of Severe Medical Emergencies and Poorer Out-of-Hospital Cardiac Arrest Outcomes in Farmlands Compared to Other Outdoor Workplaces.

Farmland is an essential yet hazardous workplace where an aging population is engaged. This study aimed to compare the characteristics and severity of emergencies between farmlands and other outdoor workplaces and clarify whether the rurality might influence the differences between farmlands and other outdoor workplaces. This retrospective cohort study analyzed the nationwide emergency medical service (EMS) transportation database between 2016 and 2021, combined with out-of-hospital cardiac arrest (OHCA) data. Farmlands emergencies accounted for 0.26% of allnon-pediatric (≥15 years)emergencies (72,162 out of 27,998,839) and 40.6% of outdoor workplace emergencies (177,923 cases). These emergencies were less frequent in winter (12.9% versus 19.7%) and during daytime hours (83.3% versus 87%) but more common in rural areas (31.4% versus 15.7%) compared to other outdoor workplaces. Farmland emergencies involved a lower proportion of male patients (67.6% versus 94.1%) and a higher proportion of older adults (≥60 years) (85.9% versus 34%), medical emergencies (42.7% versus 33.8%), outpatient deaths (3.9% versus 1.1%), and out-of-hospital cardiac arrests (OHCA) (5.1% versus 2.7%). EMSresponse and transport times were significantly longer for farmland emergencies. These differences in characteristics were more pronounced in non-rural EMS areas. Farmlands were strongly associated with higher outpatient death rates even after adjustment for other factors, with this association further strengthened in specific subgroups: non-rural emergencies, daytime hours, females, and cases not transported to high-class emergency hospitals.Regardless of the EMS rurality, OHCA in farmlands exhibited lower bystander CPR rates, fewer shockable rhythms, and limited public access defibrillation compared to other outdoor workplaces, alongside higher proportions of unwitnessed and medical cases. Neurologically favorable one-month survival was significantly lower in farmlands (1.6% versus 5.4% in rural areas and 2.9% versus 10% in non-rural areas). However, after adjusting for OHCA characteristics, survival differences were not statistically significant (95% confidence interval (CI) of adjusted odds ratio (OR): 0.41-2.63 in rural and 0.52-1.10 in non-rural EMS). Severe medical emergencies are more common in farmlands, and EMS and bystander responses to OHCA are poorer than in other outdoor workplaces, leading to worse outcomes in OHCA in farmlands. Implementing effective health and safety protocols and strategies to improve preventative health management programs and strengthening collaboration between local EMS and agricultural communities are critical to improving outcomes and aligning with the Sustainable Development Goals (SDGs) for agriculture.

MANAGEMENT OF SEVERE BALLISTIC THORACIC TRAUMA: A CASE REPORT AND REVIEW OF CURRENT PRACTICES

Ballistic thoracic trauma represents a severe medical emergency, characterized by high rates of morbidity and mortality. These injuries typically occur in the context of interpersonal violence or firearm-related accidents and are associated with significant damage to thoracic structures, including the lungs, major blood vessels, and mediastinum. Effective management of such trauma relies on the rapid recognition of clinical signs, followed by prompt interventions to prevent potentially fatal complications such as massive hemothorax or respiratory distress. This case report describes the management of a 22-year-old man who sustained severe ballistic thoracic trauma. Upon admission, the patient presented with a massive hemothorax, mediastinal shift, and signs of acute respiratory decompensation. Following initial evaluation and partial stabilization, an emergency intervention consisting of thoracic drainage was performed on-site, leading to a rapid improvement in the patients clinical condition. The objective of this work is to highlight the importance of on-site interventions in the management of severe thoracic injuries, emphasizing the challenges faced in resource-limited settings and reviewing current recommendations for the management of ballistic thoracic trauma.

Retrospective Study of the Epidemiological-Clinical Characteristics of Burns Treated in a Hospital Emergency Service (2018-2022).

Burns are a common and severe medical emergency requiring immediate specialized care to minimize damage and prevent complications. Burn severity depends on depth, extent, and location, with more complex care needed for burns on critical areas or extensive burns. Nursing is essential in burn management, providing immediate care, adapting treatments, managing pain, preventing infections, and offering emotional support for recovery. The study aims to analyse the epidemiological and clinical characteristics of burns treated at the Hospital Emergency Department of the Hospital Complex of Cáceres (Spain) from January 2018 to December 2022. It looks at factors like gender, age, hospital stay duration, emergency type (paediatric or adult), main diagnosis, skin thickness, burn degree, affected body areas, percentage of body surface area burned, and treatment types. It also investigates how treatment varies by gender, age, skin thickness, and burn severity. The relevance of this research lies in the fact that periodic epidemiological studies are essential to monitor changes in diseases, evaluate the effectiveness of interventions, detect outbreaks quickly, update knowledge on risk factors, and guide health policy decisions. This ensures an adapted and effective response to the needs of the population. Retrospective, observational study that analysed burn cases treated at the Hospital Complex of Cáceres (Spain) 2018-2022. Inclusion criteria were based on ICD-10 codes for burns, excluding severe cases not treated in this service. Data were analysed using descriptive statistics, Student's t-tests, Chi-square tests, and ANOVA. 220 patients surveyed, with a mean age of 47 years and 60.9% male. Most burns (95.5%) affected the external body surface, with a mean hospital stay of 7.86 days. Medical treatment was provided to 75.5% of patients, and 24.5% required surgical intervention. Significant differences in treatment procedures were observed according to age, skin thickness, and burn degree. Older patients had more procedures and longer hospital stays. Excision and transfer procedures were more common in full-thickness and severe burns. The findings align with previous research on burn demographics and treatment approaches. Treatment differences by age and burn severity highlight the need for tailored interventions. The study underscores the importance of comprehensive burn management, including psychological support for improved long-term outcomes. Further research could explore the impact of socio-economic factors on burn incidence and treatment. This study was not registered.

"Breaking down in tears, soaked in sweat, and sick from the heat": Media-based composite narratives of first responders working during the 2021 Heat Dome.

During the summer of 2021, a deadly, unprecedented multiday Heat Dome engulfed western Canada. As a result of this extreme heat event (EHE), emergency dispatchers received an unparalleled increase in incoming 911 calls for ambulance, police, and fire (as first responders) services to attend to hundreds of heat-vulnerable community members succumbing to the heat. With 103 all-time heat records broken during this EHE and indoor temperatures of nearly 40°C, the first responders attending these calls faced extensive job demands and highly challenging operating conditions. Initial investigations have explored the health system-level impacts; however, little has been done to explore the impact on the first responders themselves. Therefore, this study aimed to improve our understanding of EHEs' impacts on the operational capabilities and health of first responders, specifically police, fire, ambulance, and dispatch services. A systematized review and content analysis of media articles published on the 2021 Heat Dome in Canada was conducted (n = 2909), and four media-based composite narratives were developed highlighting police, fire, ambulance, and dispatch services. The Job Demands-Resources (JD-R) model was applied as atheoretical framework for occupational burnout. The media-based composite narratives highlighted that first responders faced record-breaking call volumes, increased mental-health-related claims, and exhaustive heat-related physiological stress. Using the JD-R model as a theoretical framework for occupational burnout, we identified three measures of stressful job demand: work overload (e.g., the surge in call volume, firefighters responding to medical emergencies), emotional demands (e.g., severe medical emergencies, sudden deaths, unresponsive patients, distraught family members), and physical demands (e.g., resuscitation in personal protective equipment, heat-related illness). The experiences described underscore the importance of supporting first responders during work in extreme heat conditions. These findings have important implications for addressing rising rates of burnout during and following public health crises, such as EHEs, a problem that is increasingly being recognized as a threat to the Canadian public healthcare system.

Catatonia in Renal Failure and Major Depressive Disorder: A Case Series

Catatonia is an acutely evolving and severe medical emergency. It occurs in several medical and psychiatric disorders but is often missed or misdiagnosed. There are majorly three different categories; the retarded, excited and malignant types. The latter is the most severe due to the associated autonomic instability. Much is unknown about the pathophysiology, but dysfunction of cortico-cortical modulation and a "top-down modulation" of the basal ganglia resulting from a deficiency of GABA in the cerebral cortex, resulting in motor dysfunction and glutamate hyperactivity and dopamine hypoactivity at the D2 receptor have been proposed. Benzodiazepines, especially Lorazepam, are reportedly effective, but reports of other benzodiazepines, Zopiclone and trials of mood stabilisers are documented. Electroconvulsive therapy is the suggested next line of action in case benzodiazepine fail, while the use of antipsychotic in catatonia is inconclusive. We present a case series of catatonia in 1) acute on chronic renal failure, complicated with uraemic encephalopathy and 2) severe depressive disorder with psychotic features. Physicians are encouraged to have a high index of suspicion to forestall the lethal complications.

Alcoholic/Nonalcoholic Fatty Liver Disease Detection with Transient Elastography: A Detailed Review and Meta-Analysis.

The liver plays a significant role in the digestive system, and disease in the liver initiates various other problems. The liver is severely affected due to alcohol use, and it initiates various chronic diseases, including Alcohol-Related Liver Disease (ARLD). Alcoholic/Nonalcoholic Fatty Liver Disease (AFLD/NFLD) is a severe medical emergency, and early screening and treatment are necessary to cure the patient. The untreated AFLD/NFLD will cause various problems, including fatigue, weight loss, and discomfort in the abdomen. This study aims to present a detailed review and investigation of schemes considered in medical clinics to identify the AFLD/NFLD coupled problems and present the merit of the Transient Elastography (TE) combined with Fibroscan® practice to identify liver abnormality. This research aims to study the clinical significance and the accuracy of TE-supported liver illness screening. This work aims to collect the recent research works and clinical reports published from 2011 to 2021 from the chosen databases and provide a detailed review using the clinical information discussed in the selected articles. The essential statistical investigation of the collected data is executed with Review Manager (RevMan®) software, and the significance of the TE is confirmed using the articles supporting a 2x2 contingency table, and each case is evaluated using a p-score and the Region of Convergence (RoC) curve for 95% confidence intervals.

Automated Multimodal Machine Learning for Esophageal Variceal Bleeding Prediction Based on Endoscopy and Structured Data.

Esophageal variceal (EV) bleeding is a severe medical emergency related to cirrhosis. Early identification of cirrhotic patients with at a high risk of EV bleeding is key to improving outcomes and optimizing medical resources. This study aimed to evaluate the feasibility of automated multimodal machine learning (MMML) for predicting EV bleeding by integrating endoscopic images and clinical structured data. This study mainly includes three steps: step 1, developing deep learning (DL) models using EV images by 12-month bleeding on TensorFlow (backbones include ResNet, Xception, EfficientNet, ViT and ConvMixer); step 2, training and internally validating MMML models integrating clinical structured data and DL model outputs to predict 12-month EV bleeding on an H2O-automated machine learning platform (algorithms include DL, XGBoost, GLM, GBM, RF, and stacking); and step 3, externally testing MMML models. Furthermore, existing clinical indices, e.g., the MELD score, Child‒Pugh score, APRI, and FIB-4, were also examined. Five DL models were transfer learning to the binary classification of EV endoscopic images at admission based on the occurrence or absence of bleeding events during the 12-month follow-up. An EfficientNet model achieved the highest accuracy of 0.868 in the validation set. Then, a series of MMML models, integrating clinical structured data and the output of the EfficientNet model, were automatedly trained to predict 12-month EV bleeding. A stacking model showed the highest accuracy (0.932), sensitivity (0.952), and F1-score (0.879) in the test dataset, which was also better than the existing indices. This study is the first to evaluate the feasibility of automated MMML in predicting 12-month EV bleeding based on endoscopic images and clinical variables.

Assessing Hemorrhagic Shock Severity Using the Second Heart Sound Determined from Phonocardiogram: A Novel Approach.

Introduction: Hemorrhagic shock (HS) is a severe medical emergency. Early diagnosis of HS is important for clinical treatment. In this paper, we report a flexible material-based heart sound monitoring device which can evaluate the degree of HS through a phonocardiogram (PCG) change. Methods: Progressive hemorrhage treatments (H1, H2, and H3 stage) were used in swine to build animal models. The PCG sensor was mounted on the chest of the swine. Routine monitoring was used at the same time. Results: This study showed that arterial blood pressure decreased significantly from the H1 phase, while second heart sound amplitude (S2A) and energy (S2E) decreased significantly from the H2 phase. Both S2A and S2E correlated well with BP (p < 0.001). The heart rate, pulse pressure variation and serum hemoglobin level significantly changed in the H3 stage (p < 0.05). Discussion: The change of second heart sound (S2) was at the H2 stage and was earlier than routine monitoring methods. Therefore, PCG change may be a new indicator for the early detection of HS severity.

Knowledge of Acute Pancreatitis among health-related students at Umm Al-Qura University, Saudi Arabia

Background and Aims: Acute pancreatic is a severe medical emergency requiring hospitalization with intensive care. Understanding the disease pattern helps in early diagnosing and adequately managing to prevent serious complications. Therefore, the current study aimed to study the difference in awareness and knowledge among students of health-related departments at Umm Al-Qura University. Methods: An online survey was distributed among students in September 2021. All health-related students were invited to contribute to this survey through online social media channels. This study compares the level of knowledge of acute pancreatitis. Results: 372 health-related students were surveyed, the mean age of participants was 22.79 years (SD= 1.45), and the 23–25-year age group was predominant. The majority of respondents were male and single. College of Medicine was the most responded college and 5th-year health-related students were predominant. The majority of students have a good level of awareness compared to their level of knowledge. Male participants show a significant variation in knowledge of ‘’Signs and physical examination’’ and ‘’Diagnosis workup’’ (P value, 0.001 and 0.006, respectively). A significant association was shown between students’ academic year and ‘’Overviews: - causes, symptoms, and risk factors’’, ‘’Signs and physical examination’’, ‘’Diagnosis workup’’, and ‘’ER-managements’’. Conclusion: Early diagnosis and intervention of Acute Pancreatitis are vital to prevent a series of complications. Our findings suggest that students were not acquainted with basic interventional knowledge of Acute Pancreatitis, a demand for further investigations.

Natural and Synthetic Cannabinoids: Pharmacology, Uses, Adverse Drug Events, and Drug Interactions.

The purpose of this narrative review is to describe the current use environment of both natural and synthetic cannabinoids while providing context for cannabinoid chemistry and pharmacology. In addition to a long history of recreational and nonmedical use, natural cannabinoids are increasingly used as prescription products, through medical cannabis programs, and as consumer health products. Despite anecdotal safety evidence, cannabis and cannabinoids are pharmacologically complex and pose risks for adverse drug events and drug-drug interactions. Synthetic cannabinoids, particularly agonists of cannabinoid receptors, are more potent than natural cannabinoids and can lead to more severe reactions and medical emergencies. This review provides a summary of approved uses and an overview of mechanisms of action for adverse drug events with natural and synthetic cannabinoids. Clinical considerations for special populations that may be at heightened risk for drug-drug interactions and adverse drug events while using natural or synthetic cannabinoids are examined, and recommendations are provided.

The accuracy of Bloemfontein-based Emergency Medical Services providers in recognising sepsis

Background: Sepsis is considered a severe life-threatening medical emergency and globally carries a high mortality. Research suggests early recognition of sepsis can lead to early initiation of treatment and effective communication of this condition to the receiving facility by pre-hospital emergency care (PEC) providers. Depending on system operations, this has been shown to improve patient outcomes. However, sepsis often presents non-specifically, and in the absence of validated pre-hospital sepsis screening tools, less than half of sepsis patients seen by PEC providers are recognised. This study aimed to determine the accuracy with which Bloemfontein-based PEC providers recognise sepsis in a series of patient vignettes. Methods: A series of seven case vignettes were presented to a convenient sample of advanced life support (ALS) and intermediate life support (ILS) PEC providers. The PEC providers were asked to review each vignette and indicate whether the patient described had sepsis or not. The vignettes consisted of a clinical case description with signs and symptoms of patients presenting with or without sepsis, and images were shown where relevant. Elements of the Robson Prehospital Severe Sepsis Screening (RPSS) tool were used to populate the sepsis vignettes. Results: A total of 27 ILS and ALS PEC providers in the Bloemfontein area partook in the research study. Thus, a total of 189 vignettes were evaluated for sepsis. PEC providers, both ILS and ALS, recognised sepsis with a sensitivity of 69.63% and a specificity of 37.04% (PPV 73.44%, NPV 32.79%), indicating an accuracy of 60.32%. Although all participants mentioned some motivations for their answers, none of the participants gave specific cut-off value ranges at which point they would suspect sepsis. Conclusion: This vignette-based study found that PEC providers can recognise sepsis with modest accuracy, echoing previous work on this topic. In addition, the study provides a platform for similar studies, which, in turn, could aid in the development of a validated, pre-hospital sepsis screening tool.

Cardiopulmonary resuscitation (CPR) during spaceflight - a guideline for CPR in microgravity from the German Society of Aerospace Medicine (DGLRM) and the European Society of Aerospace Medicine Space Medicine Group (ESAM-SMG)

BackgroundWith the “Artemis”-mission mankind will return to the Moon by 2024. Prolonged periods in space will not only present physical and psychological challenges to the astronauts, but also pose risks concerning the medical treatment capabilities of the crew. So far, no guideline exists for the treatment of severe medical emergencies in microgravity. We, as a international group of researchers related to the field of aerospace medicine and critical care, took on the challenge and developed a an evidence-based guideline for the arguably most severe medical emergency – cardiac arrest.MethodsAfter the creation of said international group, PICO questions regarding the topic cardiopulmonary resuscitation in microgravity were developed to guide the systematic literature research. Afterwards a precise search strategy was compiled which was then applied to “MEDLINE”. Four thousand one hundred sixty-five findings were retrieved and consecutively screened by at least 2 reviewers. This led to 88 original publications that were acquired in full-text version and then critically appraised using the GRADE methodology. Those studies formed to basis for the guideline recommendations that were designed by at least 2 experts on the given field. Afterwards those recommendations were subject to a consensus finding process according to the DELPHI-methodology.ResultsWe recommend a differentiated approach to CPR in microgravity with a division into basic life support (BLS) and advanced life support (ALS) similar to the Earth-based guidelines. In immediate BLS, the chest compression method of choice is the Evetts-Russomano method (ER), whereas in an ALS scenario, with the patient being restrained on the Crew Medical Restraint System, the handstand method (HS) should be applied. Airway management should only be performed if at least two rescuers are present and the patient has been restrained. A supraglottic airway device should be used for airway management where crew members untrained in tracheal intubation (TI) are involved.DiscussionCPR in microgravity is feasible and should be applied according to the Earth-based guidelines of the AHA/ERC in relation to fundamental statements, like urgent recognition and action, focus on high-quality chest compressions, compression depth and compression-ventilation ratio. However, the special circumstances presented by microgravity and spaceflight must be considered concerning central points such as rescuer position and methods for the performance of chest compressions, airway management and defibrillation.

Une complication rare et grave du traitement par l'acénocoumarol: l'hémorragie intra-alvéolaire

L'hémorragie intra-alvéolaire est une urgence médicale rare et grave ayant de nombreuses étiologies. Nous rapportons ainsi le cas clinique d'un patient qui pourrait contribuer à élargir la littérature sur ce sujet. Le patient est un homme âgé de 62 ans ayant un antécédent de fibrillation auriculaire sous anti-vitamines K et admis dans un tableau de dyspnée d'apparition brutale avec hémoptysie et notion d'automédication par anti-inflammatoires non stéroïdiens. La radiographie et le scanner thoracique ont montré des opacités alvéolaires bilatérales diffuses. Au bilan d'hémostase de l'admission, l'INR était incoagulable. Le diagnostic d'hémorragie intra-alvéolaire était suspecté cliniquement et radiologiquement puis confirmé par l'endoscopie bronchique avec lavage broncho-alvéolaire (LBA) retrouvant un liquide uniformément hémorragique. Les études précédentes présentant des cas similaires secondaires à la prise d'anti-vitamines K sont rares. En conclusion, Il parait très important de souligner l'intérêt d'une surveillance stricte et optimale clinico-biologique des patients traités en anti-vitamines K afin d'éviter un surdosage pouvant contribuer à un accident hémorragique grave engageant le pronostic vital.

Could glucagon-like peptide-1 be a potential biomarker of early-stage intestinal ischemia?

Intestinal ischemia, also called mesenteric ischemia, is a severe gastrointestinal and vascular medical emergency caused by a sudden decrease of blood flow through the mesenteric vessels. It generates hypoperfusion of intestinal tissues and can rapidly progress to intestinal wall infarction, systemic inflammation or even death if not treated in time. The mortality of this condition is still considerably high despite all the medical advances of the past few years. This is partially due to the difficulty of diagnosing early stage mesenteric ischemia. Indeed, a speedy and correct diagnosis is decisive for suitable medical care. However, early symptoms are unspecific and conventional clinical markers are neither specific nor sensitive enough. In the last few years, significant clinical and preclinical efforts have been made to find biomarkers which could predict gastrointestinal damage before it becomes irreversible. Here, the gut-derived hormone glucagon-like peptide-1 (GLP-1) is described as a potential early biomarker of this severe condition. Indeed, GLP-1 plasma levels rise rapidly in both mice and humans with intestinal ischemia. This discovery could counter the cruel lack of clinical biomarkers available to diagnose and therefore manage intestinal ischemia efficiently in the early stages. GLP-1 could thus become part of a panel of biomarkers for intestinal ischemia and could help to reduce the associated high mortality rates.

Adult code cart redesign: Clinical implications.

Adult code cart redesign: Clinical implications.

Endovascular Treatment of Acute Basilar Artery Occlusion: Registro Endovascolare Lombardo Occlusione Basilar Artery (RELOBA) Study Group Experience

Acute basilar artery occlusion (BAO) is considered among the most severe medical emergencies, with very high morbidity and mortality. The aims of this study are to present 5 years experience of 12 centers in Lombardy region on BAO endovascular treatment and to evaluate prognostic factors that may improve clinical outcomes and recanalization rates. Registro Endovascolare Lombardo Occlusione Basilar Artery (RELOBA) registry is a retrospective multicentric collection of patients with acute BAO who underwent endovascular treatment between 2010 and 2015. A total of 102 patients (mean age 65 years) were included. Clinical, procedural, and neuroradiological data were collected. Angiographic results (Treatment in Cerebral Ischemia scale [TICI] score 2b-3) were assessed by each center's interventional neuroradiologist. Good clinical outcome was considered as a modified Rankin Scale score ranging between 0 and 2 in a 3-month follow-up. Thirty-nine percent of patients showed good clinical outcome at 3 months. Mortality rate was 30%. TICI 2b-3 was achieved in 62% of patients. Univariate analysis showed that age, National Institutes of Health Stroke Scale (NIHSS) at onset, time to recanalization, and TICI score were all statistically significant clinical outcome predictors (P < .05). Multivariate logistic regression showed that time to recanalization, age, and NIHSS at onset were significant independent predictors of good outcome. BAO treatment needs more efforts to assure patients better clinical outcomes. Mechanical thrombectomy is feasible and effective in patients with acute BAO. These results must be confirmed by further prospective studies within randomized controlled settings.

Epidemiological profile of snake-bite cases from Haryana: A five year (2011–2015) retrospective study

Varieties of venomous snakes inhabit in the world which accidentally take thousands of human lives every year. This severe medical emergency constantly persuades national and international health agencies to look at efficient epidemiological profiling of snake-bite cases for the proper management of this sympathetic problem. Establishing the accurate database of snake-bite in humans from different localities of India may perhaps lack certainty due to few inevitable reasons such as consideration of this problem as less emergent problem in disparity to pesticide poisoning, difficulty in the accessibility to rural and tribal areas where chances of snake-bite remain ceiling, lack of inspiring models of snake-bite management training, reduced reporting system, and pitiable maintenance of hospital data in India. Therefore, the present modest study was carried out to explore valuable information regarding snake-bite problem in Haryana. Factual data on snake-bite incidences happened from 2011 to 2015 were collected from government hospitals and medical institutes of Haryana. This retrospective study disclosed a few characteristic points related to the frequency of snake-bite cases, gender involved, anti-snake venom (ASV) treatment, and numbers of deaths with snake-bite. Records revealed a total of 6555 cases of snake-bite including 130 deaths reported in Haryana during the study period. A significant variation in the occurrence of snake-bite cases was also recorded in different areas of Haryana. There was a huge database of recorded snake-bite cases from government medical institute but district wise survey disclosed the maximum number of snake-bite incidences, especially amongst males from Panchkula. The present study has provided a more updated and comprehensive record of snake-bite from Haryana during 2011–2015. A huge burden of snake-bite amongst human was found in Haryana; hence, the findings of this study purposely enlighten people about the size of this problem in the selected region. However, this study also remained limited due to lack of information on a few important parameters and availability of homogeneous data.

Role of N-acetylcysteine treatment in non-acetaminophen-induced acute liver failure: A prospective study.

Background/Aims:Acute liver failure (ALF) is a rare but severe medical emergency. To date, there is no established treatment for non-acetaminophen-induced acute liver failure (NAI-ALF) other than liver transplantation, and little is known about the use of N-acetylcysteine (NAC) in NAI-ALF. A randomized case control study was conducted with the aim to determine the effect of NAC on the mortality of NAI-ALF patients, as well as to evaluate the safety and efficacy of NAC use.Patients and Methods:A total of 80 patients diagnosed with NAI-ALF were included in the study. Forty patients received NAC infusion for 72 h whereas the control group received placebo. The variables evaluated were demographic characteristics, signs and symptoms, biochemical parameters, and clinical course during hospitalization.Results:The two groups (NAC and control) were comparable for various baseline characteristics (such as etiology of ALF, INR, alanine aminotransferase, creatinine, albumin, and grade of encephalopathy), except for age. Although majority of patients had undetermined etiology (32.5% in NAC group and 42.5% in control group), the second main cause was acute hepatitis E and drug or toxin-induced ALF. The mortality decreased to 28% with the use of NAC versus 53% in the control group (P = 0.023). The use of NAC was associated with shorter length of hospital stay in survived patients (P = 0.002). Moreover, the survival of patients was improved by NAC (P = 0.025). Also, drug-induced ALF showed improved outcome compared to other etiologies.Conclusion:The findings of the study recommend the use of NAC along with conventional treatments in patients with NAI-ALF in non-transplant centers while awaiting referrals and conclude the use of NAC as safe.

Severe rhabdomyolysis after head and neck surgery

Rhabdomyolysis constitutes a severe medical emergency that requires immediate recognition and prompt treatment to prevent serious consequences. There are a variety of causes, but rhabdomyolysis after head and neck surgery is very rare. Here, we present a patient who underwent right parotidectomy and complicated with acute kidney injury secondary to severe postoperative rhabdomyolysis. Physicians require special attention for the high-risk patients to avoid severe complications.

Utstein-style reporting of out-of-hospital cardiac arrest in the Bielsko-Biała county

Introduction. Out-of-hospital cardiac arrest (OHCA) is one of the most severe medical emergencies, with significantly high both pre- and in-hospital mortality rates. The aim of the study was to assess the quality of reporting OHCA data by the Emergency Medical Service teams (EMS) in the Bielsko-Biala county, using standard ambulance dispatch cards. Material and methods. The study included adult inhabitants of Bielsko-Biala county who suffered from OHCA in 2013. Data were retrieved from standardised PRM forms, and compared to the Utstein style template. The study group comprised 272 patients, 190 (70%) males and 82 (30%) females, with a median age of 71 years (IQR 60–80). The pre-hospital mortality rate was 76.5% (75.3% in men and 79.3% in women). Results. The potential cause of OHCA was least known, with only 22% of forms including any information concerning this issue. Suboptimal reporting on the data enabling patient identification was noted in 12% cases. There was no association between reporting style and time and place of the OHCA. Conclusions. The overall quality of reporting of OHCA by PMR in Bielsko-Biala was good. The greatest concern was inability to identify the potential cause of the event, which can significantly influence application of adequate treatment.