This prospective randomized study was designed to evaluate the efficacy of intravenous clonidine, esmolol, lidocaine and placebo in suppressing the hemodynamic changes during endotracheal intubation. A total of one hundred and twenty patients belonging to ASA 1 and 2 were randomly divided into four groups. Patients in group A received clonidine 2 mcg/kg, in group B received Esmolol 1mg/kg, in group C received lidocaine 1.5 mg/kg and in group D received normal saline two minutes prior to induction. Patients in group A showed the maximum attenuation of both heart rate and blood pressure following endotracheal intubation. Patients in group B showed a significant attenuation of heart rate as effective as group A but attenuation of blood pressure (though effective than groups C and D) was not as effective as group A. Patients in group C showed no significant difference from group P in attenuating circulatory responses and both lignocaine and placebo were ineffective. All the patients were recovered well from anesthesia and none of them developed complications like severe Bradycardia (HR< 50/min) or profound hypotension (SBP<80mmHg).