Severe Artery Disease Research Articles

Multivessel coronary bed lesion in patients with stable coronary artery disease: Current state of the problem and gap in evidence

World statistics data suggest that the surgical revascularization of the myocardium in multivessel coronary artery disease is performed in 40 to 60% of cases. However, severity of coronary artery disease is often evaluated through the analysis of clinical presentation and selective coronary angiography (ICA) data without an assessment of the functional significance of stenosis. A precise algorithm for the treatment of patients with multivessel coronary artery disease and stable coronary artery disease is still unavailable, i.e. extent of revascularization, its time, and criteria for complete withholding of surgical treatment remain unclear. Many factors affect myocardial blood supply in multivessel disease including the type of blood supply to the heart, presence of scar and collaterals, diameter of the affected artery, and presence of microvascular dysfunction. All these factors require rational and intelligent approach to establishing the optimal tactics. In this review, the authors identified discussion vector and presented their original opinion on the advisability/unreasonableness of approaches to revascularization in patients with multivessel coronary disease based on published clinical trials and current recommendations. In addition, we analyzed the existing data, identified the missing information, and proposed the prospects for possible new clinical studies in this scientific field.

Association between non-alcoholic fatty liver disease and epicardial adipose tissue volume with cardiometabolic risk in coronary heart disease

BackgroundRegional adiposity has a significant impact on the formation of adverse metabolic and cardiovascular risk profiles. While much of the attention was directed to the importance of intra-abdominal adipose tissue, there were several new investigations about mediastinal and epicardial regions’ visceral adiposity. Our study aimed to determine the association between non-alcoholic fatty liver and increased epicardial adipose tissue mass with coronary artery disease severity.MethodsThis study was conducted on sixty patients who presented with symptoms of coronary artery disease and attended elective coronary angiography to rule out coronary artery disease. All patients have been subjected to full hepatic profile, noninvasive scoring system such as Fibrosis-4 and non-alcoholic fatty liver disease fibrosis score and abdominal ultrasound for diagnosis of non-alcoholic fatty liver disease and trans-thoracic echocardiography for measurement of average epicardial adipose tissue thickness. Student T test, analysis of variance test, chi-square test, and Fisher’s exact test were used for statistical analysis.ResultsAccording to the severity of coronary artery disease, patients with significant coronary stenosis had statistically significant higher degree of hepatic steatosis in abdominal ultrasound (P value < 0.001) while regarding the non-alcoholic fatty liver disease fibrosis score and Fibrosis-4 for non-alcoholic fatty liver disease diagnosis, there was no significance between both groups. Also, the epicardial adipose tissue mean thickness was found to be statistically significantly higher among those with significant coronary stenosis than those without [7.859 ± 0.691 mm versus 5.600 ± 0.386 mm]. Moreover, statistically significant higher epicardial adipose tissue thickness values were found among grade 3 hepatic steatosis than in grades 2, 1, or 0 (P value < 0.001). At a cutoff > 6.1 mm, epicardial adipose tissue thickness was a valuable tool in discrimination between significant and non-significant coronary artery disease with specificity and sensitivity of 100%.ConclusionHigh epicardial adipose tissue thickness may represent a marker of severity of non-alcoholic fatty liver disease as well as an independent predictor of coronary artery disease risk.

The mir-21 Inhibition Enhanced HUVEC Cellular Viability during Hypoxia-Reoxygenation Injury by Regulating PDCD4.

The purpose of this study was to explore the clinical value of altered plasma mir-21 expression level as a biomarker for the severity of coronary artery disease (CAD) and its molecular impact on HUVEC cellular injuries. Angiographically validated 56 patients with single-vessel CAD disease, 92 patients with double-vessel CAD, 139 complex coronary artery stenosis patients, and 56 healthy individuals (n = 343) were enrolled in this study. The expressions of plasma mir-21 were evidently and progressively higher while PDCD4 levels were significantly and steadily lower in single-, dual-, and multivessel occluded CAD patients than in healthy participants (P < 0.001). The relative expressions of mir-21 in hypoxia-reoxygenation- (HR-) exposed HUVECs were markedly upregulated, but PDCD4 concentrations were obviously downregulated as compared with normal control cells (P < 0.001). Moreover, altered circulatory mir-21 expression levels were able to significantly differentiate single- (AUC 0.893), double- (AUC 0.914), and multivessel stenosis CAD (AUC 0.933) patients from healthy subjects. Besides, the plasma mir-21 expressions in elderly (66-85 years) groups were remarkably higher than those in younger aged (25-45 years) subjects. Caspase-3 and ROS expression levels were remarkably elevated, but cellular viability noticeably declined in HR-induced HUVECs than in normoxic cells (P < 0.001). In contrast, mir-21 inhibition markedly reduced caspase-3 activity and ROS concentrations while significantly ameliorating HUVEC cellular viability in HR conditions. PDCD4 expressions in HR-exposed HUVECs were prominently decreased whereas mir-21 inhibition significantly enhanced PDCD4 levels (P < 0.001). Upregulated plasma mir-21 can be a valuable clinical biomarker for the detection of the severity of coronary artery stenosis patients. Elevated circulatory mir-21 concentrations have a positive correlation with aging. Inhibitory mir-21 evidently increased HUVEC cellular viability through upregulation of targeting PDCD4 and recommended a newer possible therapeutic molecule for the management of CAD patients.

Effects of Hypertension on the Incidence of Acute Coronary Syndrome and Severity of Coronary Artery Disease in Young Women

Abstract Background To investigate the effects of hypertension on the prevalence of acute coronary syndrome (ACS) and the severity of coronary artery disease in young women in northern China. Methods A retrospective analysis was performed on 840 young female patients (age &amp;lt;45 years old) underwent coronary angiography due to chest pain or chest discomfort between January 2007 and December 2016. The patients were divided into hypertension group (256 cases) and control group (584 cases). The risk factors and prevalence of ACS, and coronary stents implantation in the 2 groups were studied. Results The prevalence of ACS was higher in the hypertension group compared with the control group (80.9% vs. 36.5%, P &amp;lt; 0.05). The rates of hyperlipidemia (37.1% vs. 14.9%), hypercholesterolemia (8.6% vs. 3.4%), hyperuricemia (18.4% vs. 7.2%), and hyperhomocysteinemia (10.9% vs. 3.9%) were all significantly higher in the hypertensives compared with controls (all P &amp;lt; 0.05). The hypertension group had higher rates of overweight (63.7% vs. 29.5%), family history of early coronary heart disease (15.2% vs. 5.5%), smoking (5.5% vs. 4.3%), menopause (4.7% vs. 1.7%), and type 2 diabetes (24.2% vs. 8.9%) compared with the control group (all P &amp;lt; 0.05). Double branch lesions of coronary artery in hypertension and control groups were 14.1% and 5.7%, respectively (P &amp;lt; 0.05). Further, hypertensive patients with ACS had higher number (1.67 ± 1.05 vs. 1.41 ± 0.85) and longer (24.44 ± 6.97 vs. 22.85 ± 7.80 mm) stents implantation than the control group (P &amp;lt; 0.05). Conclusions Hypertension is the main risk factor of ACS in young women in northern China. Young women with hypertension have more risk factors for atherosclerotic cardiovascular disease.

Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity.

Correction to: Outcomes in the ISCHEMIA Trial Based on Coronary Artery Disease and Ischemia Severity.

Clinical value and expression of Homer 1, homocysteine, S-adenosyl-l-homocysteine, fibroblast growth factors 23 in coronary heart disease

BackgroundThis study aimed to explore clinical value and expression of Homer 1, S-adenosyl-l-homocysteine (SAH), homocysteine (Hcy), fibroblast growth factors (FGF) 23 in coronary heart disease (CHD).MethodsFrom March 2020 to April 2021, a total of 137 patients with CHD and 138 healthy subjects who came to our hospital for physical examination and had no cardiovascular disease were retrospectively enrolled, and they were assigned to the CHD group and the control group, respectively. Patients in the CHD group were divided into stable angina pectoris (SAP) group (n = 48), unstable angina pectoris (UAP) group (n = 46), and acute myocardial infarction (AMI) group (n = 43) according to clinical characteristics for subgroup analysis. The degree of coronary artery stenosis was assessed by Gensini score, which is a reliable assessment tool for the severity of coronary artery disease. The levels of Homer 1, SAH, Hcy, and FGF 23 were tested and compared. Spearman correlation analysis was used to analyze the correlation between serum Homer1, SAH, Hcy, FGF23 levels and Gensini score, and multivariate unconditional Logistic regression was used to analyze the risk factors of coronary heart disease.ResultsDemographic characteristics of each group were comparable (P > 0.05). The body mass index (BMI), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and glucose levels of the SAP group, UAP group and AMI group were significantly higher than those of the control group, and the number of patients with smoking, alcohol consumption, hypertension, and diabetes history was significantly more than that of the control group, respectively (P < 0.05). The level of high-density lipoprotein cholesterol (HDL-C) of each subgroup was significantly lower than the control group (P < 0.05). The above indicators showed no significant difference among three subgroups (P > 0.05). Serum SAH, Hcy, Homer1 and FGF23 levels in each subgroup were significantly higher than those in control group (P < 0.05). And above indicators in SAP group and UAP group were significantly lower than those in AMI group (P < 0.05), and the levels of above indicators in SAP group were significantly lower than those in UAP group (P < 0.05). The results of Spearman correlation analysis showed that serum Homer1, FGF23, SAH, Hcy levels were positively correlated with Gensini score (r = 0.376, 0.623, 0.291, 0.372, all P < 0.01). Multivariate logistic regression analysis showed that smoking, hypertension, diabetes, alcohol consumption, obesity, HDL-C, FGF23, SAH, Hcy, Homer 1 were independent risk factors for coronary heart disease.ConclusionThe levels of FGF23, SAH, Hcy, and Homer1 tend to increase in patients with CHD compared with normal population, and the more severe the disease, the higher the levels, which has certain reference value for the clinical diagnosis of CHD and the evaluation and monitoring of the disease.

Correlation of Red Blood Cell Distribution Width with The Severity of Coronary Artery Disease

Atherosclerosis causing occlusion of coronary vessels by building up of plaque leading to narrowing of vessels supplying heart and causing coronary artery disease, which is the leading and common cause of mortality around the globe. Objective: To find the correlation of Red Cell Distribution Width (RDW) and severity of Coronary Artery Disease (CAD) lesions Methods: A number of 280 patients in total, admitted to cardiology department who presented with chest pain and diagnosed as angina, positive treadmill test and who underwent angiography and were found to have CAD, were enrolled in the study over a period of one year. Modified Gensini score (MGS) is used for assessment of severity of CAD. Each patient was assessed in relation to severity of CAD using MGS scoring system. Results: Out of 280 patients, 218 were assigned to Group A and 70 were assigned to Group B. Mean age of presentation were (52.34± 13.90 vs 50.8± 11.63 years). Male subjects were predominant overall with ratio of 2.63:1. RDW was assessed and was seen to be significantly elevated in Group A in comparison to Group B (14.98± 1.59 vs 13.82 ± 0.91p= &lt;0.0001). After assessing MGS in relation to severity of CAD, significant correlation was observed. RDW was found to be increasing as MGS score increased (14.46± 0.65 vs 14.98± 1.00 vs 15.02± 0.88, p= &lt;0.0001) Conclusions: It was concluded that RDW is a parameter which is cost effective, very easy, readily and urgently available for the assessment and stratification of patients presenting with coronary artery disease.

Status of exercise duration and metabolic equivalents in interpretation of exercise electrocardiography testing

Both exercise duration and metabolic equivalent give an idea about the effort tolerance of the patient. Effort tolerance depends on several factors e.g. cardiac status, pulmonary status, neuromuscular status, psychological status, physical conditioning, age, sex, haemoglobin concentration etc. Therefore, diminished effort tolerance alone, in absence of other evidence, can not be taken as an indication of the presence or severity of coronary artery disease or left ventricular dysfunction. Regression equations used for calculation of metabolic equivalent (MET) include speed and inclination of the treadmill (stage of particular protocol) in addition to the duration of exercise. MET, therefore, gives a more correct impression about the workload achieved by a given patient. For the same reason, MET is useful for comparing the reports of different treadmill tests performed by different protocols at different times. It helps in assessing the progression of the disease. Regression equations used by most of the conventional treadmill systems do not include other factors that affect effort tolerance. These include the age, sex, and weight of the patient. This is an important limitation. Keywords: Coronary Artery Disease; Exercise Electrocardiography; Left Ventricular Function; Myocardial Ischemia; Metabolic Equivalent; Treadmill Test

Impact of plasma glucose and duration of type 2 diabetes mellitus on SYNTAX Score II in patients suffering from non ST-elevation myocardial infarction.

Aim The objective was to assess the correlation of fasting plasma glucose (FPG), HbA1c, and the duration of type 2 diabetes mellitus (T2DM) with SYNTAX score (SS) II in patients with non-ST elevation myocardial infarction (NSTEMI).Material and methods FPG and HbA1C were measured in 398 patients presenting with NSTEMI at admission. SS II was calculated using an online calculator. Patients were stratified according to SS II (≤21.5, 21.5-30.6, and ≥30.6), defined as SS II low, mid, and high, respectively.Results 37.7 % of subjects were diabetic. Correlations of FPG (R=0.402, R2=0.162, p&lt;0.001) and HbA1c (R=0.359, R2=0.129, p&lt;0.001) with SS II were weak in the overall population. Duration of T2DM showed very strong correlation with SS II (R=0.827, R2=0.347). For the prediction of high SS II in the study population, FPG≥98.5 mg / dl demonstrated a sensitivity of 58 % and a specificity of 60 %, and HbA1c ≥6.05 demonstrated a sensitivity of 63 % and a specificity of 69 %. Duration of T2DM (adjusted odds ratio (OR): 1.182; 95 % confidence interval (CI): 1.185-2.773) and FPG (OR: 0.987; 95 % CI: 0.976-0.9959) were significantly associated with high SS II after controlling for other risk factors. Duration of T2DM (Beta=0.439) contributed strongly to variance of SS II, whereas HbA1c (Beta=0.063) contributed weakly.Conclusion Duration of T2DM is a very important risk factor for severity of coronary artery disease.

Using Text Content From Coronary Catheterization Reports to Predict 5-Year Mortality Among Patients Undergoing Coronary Angiography: A Deep Learning Approach

BackgroundCurrent predictive models for patients undergoing coronary angiography have complex parameters which limit their clinical application. Coronary catheterization reports that describe coronary lesions and the corresponding interventions provide information of the severity of the coronary artery disease and the completeness of the revascularization. This information is relevant for predicting patient prognosis. However, no predictive model has been constructed using the text content from coronary catheterization reports before.ObjectiveTo develop a deep learning model using text content from coronary catheterization reports to predict 5-year all-cause mortality and 5-year cardiovascular mortality for patients undergoing coronary angiography and to compare the performance of the model to the established clinical scores.MethodThis retrospective cohort study was conducted between January 1, 2006, and December 31, 2015. Patients admitted for coronary angiography were enrolled and followed up until August 2019. The main outcomes were 5-year all-cause mortality and 5-year cardiovascular mortality. In total, 11,576 coronary catheterization reports were collected. BioBERT (bidirectional encoder representations from transformers for biomedical text mining), which is a BERT-based model in the biomedical domain, was utilized to construct the model. The area under the receiver operating characteristic curve (AUC) was used to assess model performance. We also compared our results to the residual SYNTAX (SYNergy between PCI with TAXUS and Cardiac Surgery) score.ResultsThe dataset was divided into the training (60%), validation (20%), and test (20%) sets. The mean age of the patients in each dataset was 65.5 ± 12.1, 65.4 ± 11.2, and 65.6 ± 11.2 years, respectively. A total of 1,411 (12.2%) patients died, and 664 (5.8%) patients died of cardiovascular causes within 5 years after coronary angiography. The best of our models had an AUC of 0.822 (95% CI, 0.790–0.855) for 5-year all-cause mortality, and an AUC of 0.858 (95% CI, 0.816–0.900) for 5-year cardiovascular mortality. We randomly selected 300 patients who underwent percutaneous coronary intervention (PCI), and our model outperformed the residual SYNTAX score in predicting 5-year all-cause mortality (AUC, 0.867 [95% CI, 0.813–0.921] vs. 0.590 [95% CI, 0.503–0.684]) and 5-year cardiovascular mortality (AUC, 0.880 [95% CI, 0.873–0.925] vs. 0.649 [95% CI, 0.535–0.764]), respectively, after PCI among these patients.ConclusionsWe developed a predictive model using text content from coronary catheterization reports to predict the 5-year mortality in patients undergoing coronary angiography. Since interventional cardiologists routinely write reports after procedures, our model can be easily implemented into the clinical setting.

Determining the factors associated with the pattern and severity of coronary artery involvement in patients with acute coronary syndrome

Introduction: Acute coronary artery syndrome is a term to describe a wide range of diseases associated with a sudden and severe decrease in blood flow to the heart. Objectives: This study aimed to evaluate the variables related to the severity and type of coronary artery involvement in patients with the acute coronary syndrome (ACS). Patients and Methods: This study is a retrospective analytical descriptive study. The statistical population of this study included patients who were admitted to the vascular ward of Shahid Mohammadi hospital in Bandar-Abbas during 2017-2020 with a diagnosis of the ACS and underwent coronary angiography. Results: In the study of the main vessel involvement, left anterior descending artery (LAD) with 38.15% and RCA with 23.97% were the most common vessels involved. The most involved vessels were LAD-right coronary artery (LAD-RCA) (8.61%), left circumflex artery (LCX) (7.95%), obtuse marginal artery (OM) (7.68%) and diagonal arteries (4.77%), respectively. The most common sites of involvement in Chen’s anterior descending vessel were the middle part of LAD (m.LAD), the proximal part of LAD (p.LAD), and then the distal part of LAD (d.LAD), respectively. Most of the places of conflict RCA, precisely similar to LAD, were the middle part of RCA (m.RCA), the proximal part of RCA (p.RCA) and the distal part of RCA (d.RCA). There was a statistically significant relationship between the severity of coronary artery disease (CAD) according to age, gender, diabetes, blood pressure, family history and the number of vessels involved. There was no statistically significant relationship between the severity of coronary artery involvement, smoking and mean body mass index (BMI). Conclusion: As it is shown, our results were quite similar to other studies around the country. Hence, following the nationwide guidelines for treating CVD in this city seems rational and helpful.

A SURVEY ON THE PERIODONTAL STATUS OF PATIENTS WITH CORONARY ARTERY DISEASE AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

Background: The relationship between periodontal disease and coronary artery disease has been suggested for more than a century. This study was carried out with the goal of surveying periodontal status in patients with coronary artery disease and understanding the relationship between periodontal status and severity of coronary artery disease. Subjects and methods: The study was conducted on two groups, including 50 patients with coronary artery disease, compared with control groups of the same age, sex. All subjects had a clinical dental examination to assess the periodontal indicators. Assessment of severity through coronary angiography in the group of diseases, thereby determining the relationships and correlations. Results: In the disease group, the average plaque index (1.96 ± 0.64), gingival index (1.49 ± 0.47) and clinical attachment loss (2.68 mm ± 1.12) was statistically significantly higher than the control group (p &lt; 0.05). There was no difference in the periodontal pocket depth index between the two groups (p&lt;0.05). The difference in the degree of gingivitis between the two groups was statistically significant (p&lt;0.05). The average of periodontal indexes gradually increased according to the degrees of coronary artery stenosis (p&lt;0.05).There is a significantly moderate positive correlation between the degree of coronary artery stenosis and the degree of periodontitis. Conclusions: There is an relationship between periodontal status and severity of coronary artery disease. Recognizing this relationship, we need to take measures to change people’s awareness about oral health with coronary heart disease through periodic dental examination and treatment Key words: Periodontal disease, coronary artery disease, relationship

Blood Group O Protect End-Stage Renal Disease Patients With Dialysis From Coronary Artery Disease.

ObjectiveOur study aims to investigate the role of the ABO blood group in the development and severity of coronary artery disease (CAD) in end-stage renal disease (ESRD) patients with dialysis.MethodsA total of 408 ESRD patients with dialysis between January 2010 and December 2020 were enrolled including 204 patients diagnosed with CAD undergoing coronary angiography for the first time, and baseline characteristics as well as Gensini score (GS) were collected. Logistic regression analysis and linear regression analysis were performed to evaluate the relation of ABO blood types to the risk and severity of CAD, respectively.ResultsBlood group O frequency was significantly low in dialysis ESRD patients with CAD (25 vs. 38.24%) compared with the non-CAD patients and multivariable logistic regression showed blood group O was negatively associated with the risk of CAD [adjusted odds ratio (OR) = 0.33, 95% CI = 0.19–0.60, p < 0.001] as well as the GS tertiles (adjusted OR = 0.23, 95% CI = 0.11–0.49, p < 0.001) compared with A blood group. Blood group A, B, and AB were positively associated with the high Gensini tertile compared with O blood group (adjusted OR = 4.26, 95% CI = 2.03–8.93, p < 0.001; adjusted OR = 2.39, 95% CI = 1.11–5.13, p < 0.05; adjusted OR = 4.33, 95% CI = 1.40–13.35, P < 0.05). Similarly, multivariable linear regression results revealed O blood type was negatively associated with the GS (β = −26.129, 95% CI = −40.094 to −12.164, p < 0.001).ConclusionThis case-control study demonstrated that blood group O was a potential independent protective factor for the risk and severity of CAD in ESRD patients with dialysis.

The association between ABO blood groups and TASC II classification in patients with peripheral artery disease.

The aim of this study was to investigate the association between blood groups and severity of peripheral artery disease (PAD) using TASC II classification. The patients who were diagnosed with PAD were retrospectively analyzed. The patients with 50% or more stenosis in the aorto-iliac or femoro-popliteal region detected by conventional or CT angiography were included in the study. These patients were divided into TASC II A, B, C, and D groups considering the severity of PAD. All patients' blood groups were recorded and compared between TASC II groups. While 38% of the study population was O blood group, 61% were non-O group. On the other hand, 90% of the entire study population were RH positive and 10% were RH negative. Non-O blood ratio was found to be significantly higher in patients with higher TASC II groups. (TASC IIA 51.6% vs. TASC IIB 57.9% vs. TASC IIC 61.3% vs. TASC IID 76.6%, p< .001) However, the frequencies of Rh types were similar in all groups. Multiple logistic regression analysis was applied for determining the predictors of severity and complexity of PAD (TASC II C and TASC II D lesions). Our study results revealed a clear association between ABO blood groups and severity of peripheral arterial disease. Non-O blood group was found to be the independent predictor of severe and complex PAD.

Serum Branched Chain Amino Acids May Determine the Severity of Coronary Artery Disease as Evidenced by Regression Modelling Ahsan Mushtaq

Serum Branched Chain Amino Acids May Determine the Severity of Coronary Artery Disease as Evidenced by Regression Modelling Ahsan Mushtaq

Association between fibrinogen-to-albumin ratio and the presence and severity of coronary artery disease in patients with acute coronary syndrome

ObjectiveAlthough the levels of plasma fibrinogen and albumin have been proven to be in relation to coronary heart disease (CHD), the association between fibrinogen-to-albumin ratio (FAR) and acute coronary syndrome (ACS) has not been adequately investigated. The aim of this study is to investigate the relationship between FAR and the presence and severity of CHD in patients with ACS.Methods and resultsA total of 1575 individuals who received coronary angiography (CAG) were enrolled. Patients were divided into the ACS group and the control group. The severity of ACS was determined by Gensini score, number of diseased coronary artery and the presence of myocardial infarction (MI). Data showed that the level of FAR in ACS group was higher than in the control group (81.20 ± 35.45 vs. 72.89 ± 20.24, P < 0.001). The results from subgroup analysis indicated that the values of FAR in the high Gensini score group, MI group and multiple-vessel stenosis group were higher than the matched subgroups. After adjustment for confounders, FAR was still independently related to the presence and severity of ACS (MI OR 2.097, 95%CI 1.430–3.076; High GS: OR 2.335, 95%CI 1.567–3.479; multiple-vessel disease: OR 2.088, 95%CI 1.439–3.030; P < 0.05).ConclusionThe levels of FAR are independently associated with the presence and the severity of coronary artery disease in patients with ACS. Furthermore, FAR, as a more convenient and rapid biological indicator, may provide a new idea for predicting the presence and severity of ACS.

Features of the structural state of the myocardium in patients with myocardial infarction without ST segment elevation depending on the nature of the anatomical lesion of the coronary arteries

Annotation. In Ukraine, one of the most pressing medical and social problems is coronary heart disease, in particular, such a form as myocardial infarction. Also, as in most countries, coronary heart disease plays a leading role in morbidity and mortality. In Ukraine, coronary heart disease accounts for 65% of the mortality from diseases of the circulatory system of the working population and is the main cause of disability. The aim of the work is to determine the features of the structural and functional state of the myocardium in patients with myocardial infarction without ST segment elevation depending on the nature of the anatomical lesion of the coronary arteries. We conducted a comprehensive study of 200 patients with acute myocardial infarction without ST-segment elevation (NSTEMI) aged 38 to 80 years. According to coronary angiography, the degree of damage to the coronary arteries was determined, and according to echocardiography – the structural and functional state of the myocardium. Comparison of percentages between groups was performed by the criterion χ2, absolute values – by Mann-Whitney U test. The structural condition of the left ventricular myocardium in NSTEMI patients deteriorated significantly. The total severity of coronary artery disease, calculated from coronary angiography, was&gt; 3, indicating a more severe anatomical lesion of the coronary arteries in these patients. This pathology was associated primarily with an increase in the incidence of eccentric left ventricular hypertrophy. A similar association has been established with regard to the development of left ventricular diastolic dysfunction.

Evaluation of monocyte/lymphocyte ratio, CRP/albumin ratio and glycated hemoglobin to predict the severity of coronary artery disease in non-diabetic patients: Correlation with SYNTAX SCORE

Evaluation of monocyte/lymphocyte ratio, CRP/albumin ratio and glycated hemoglobin to predict the severity of coronary artery disease in non-diabetic patients: Correlation with SYNTAX SCORE

Prevalence of elevated lipoprotein (a) in atherosclerotic cardiovascular disease and its relation to severity of coronary artery disease

Prevalence of elevated lipoprotein (a) in atherosclerotic cardiovascular disease and its relation to severity of coronary artery disease

Abstract 10888: Lipid Profile Predicts Number and Length of Coronary Artery Stents

Introduction: Higher levels of low-density lipoprotein (LDL) are associated with an increased incidence of cardiovascular events. Little is known about the impact of lipid profile on the severity and extent of disease. This study aims to characterize the lipid profile’s ability to predict the number of and total length of coronary artery stents. Hypothesis: In patients undergoing percutaneous coronary intervention, the lipid panel is predictive of the total length and number of coronary stents deployed. Methods: We retrospectively identified unique, consecutive patients undergoing percutaneous coronary intervention at a single center from April 2018 to March 2021. Inclusion criteria included the availability of a lipid panel in the electronic medical record. Associations between lipid levels with stent number or stent length were tested by univariable linear regression. Results: For a single coronary angiogram procedure, 1547 unique patients had a lipid panel in the EMR within 2 weeks of the procedure with a median of 2 stents deployed with median total stent length of 38 mm. High-density lipoprotein (HDL), LDL, but not total cholesterol, triglycerides (TG), were predictive of stent length (HDL inversely, p =0.004; LDL p =0.01) and number of stents (HDL inversely, p =0.008; LDL p =0.04). Conclusions: These results indicate that the lipid panel has implications for the severity and extent of coronary artery disease found during coronary angiography, reflected in the number of and total length of coronary artery stents.