Severe Acne Vulgaris Research Articles

Assessment of the Effect of Rehmannia glutinosa Leaf Extract in Maintaining Skin Health: A Proof-of-Concept, Double-Blind, Randomized, Placebo-Controlled Clinical Trial.

A double-blind, placebo-controlled, randomized, proof-of-concept trial aimed to evaluate the efficacy and safety of VerbasnolTM [Rehmannia glutinosa Libosch leaf-based extract (RGLE)] in females, with moderate to severe acne vulgaris. Twenty-two females aged 18 to 35 years having moderate to severe acne with Global Acne Grading System (GAGS) scores of 19 to 38 were included in the study and were randomized in a 1:1 ratio to receive either one capsule (100 mg/day) of RGLE or placebo orally after breakfast for 56 days. The primary outcome was a change in acne severity measured by the GAGS compared to the placebo on day 56. The secondary outcomes were changes in the number of inflammatory acne lesions, facial sebum secretion, quality of life, local pain and itching, skin wrinkle severity, and other skin characteristics, including radiance, luminosity, smoothness, texture, firmness, and hydration. Additionally, the percentage of responders and global tolerability and efficacy were evaluated. The mean GAGS score was reduced by 21.72% and 14.20% on day 28 in RGLE (n=10) and placebo groups (n=12), respectively, which further reduced in both groups on day 56. The RGLE group reported better improvement in other skin characteristics on day 56. No safety or tolerability concerns were reported for the extract. RGLE reduced acne and improved the skin quality in females compared to placebo as early as 28 days of supplementation. RGLE supplementation at a dose of 100 mg/day has provided a clinically relevant decrease in acne severity and improved the skin hydration and quality of life of the participants with acne after 56 days of dose administration.

A Randomized, Split-Face, Comparative Study of a Combined Needle Radiofrequency/Intense Pulsed Light Device in Moderate-to-Severe Acne Patients.

Radiofrequency (RF) and intense pulsed light (IPL) have been reported as efficient adjuvant treatment modalities for acne vulgaris. We sought to evaluate the clinical efficacy and safety of a combined needle RF and vacuum IPL device for acne treatment without the use of other conventional topical or oral agents. This randomized, split-faced study was designed to include patients with moderate to severe acne vulgaris. Comedone extraction was performed on both parts of the face prior to laser treatment. One side of the face was treated with RF and IPL in 2-week intervals, while the other side was left untreated as a control. Two independent blinded investigators evaluated the patients for improvement using clinical photographs. We also assessed for possible adverse effects. The study included 44 patients with acne vulgaris (27 men and 17 women). Their ages ranged from 19-39 years (average, 23 years). At the final 12-week follow-up visit, the acne reduction rate was 34.80% (±33.45%; range, 30.92%-19.03%) on the treated side and 13.76% (±37.58%; range, 28.26%-23.27%) in the control group compared to baseline, constituting a significant difference. The difference in reduction rate between the treated and control sides was 21.03% (±25.09%), with the treated side experiencing more significant improvement (p<0.05). In the assessment of adverse events, one patient experienced mild surrounding erythema that spontaneously improved. Combined treatment of needle RF and IPL could improve acne lesions.

Isotretinoin Use and Liver Enzymes Changes: A Single-Center Study in Saudi Arabia.

Introduction Isotretinoin is a bioactive retinoic acid variant that is taken orally to treat moderate to severe acne vulgaris. One of the adverse effects of isotretinoin is elevated liver enzymes. This study estimated the prevalence of liver enzyme changes during isotretinoin use among dermatology clinic patients in Al-Ahsa, Kingdom of Saudi Arabia. Methods This study was a retrospective analysis that reviewed the medical data of 97 patients with acne at the King Faisal University Polyclinic who were taking systemic isotretinoin. It determined the baseline, second, and last readings of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Among the 97 patients, 67 (69.1%) were female and 30 (30.9%) were male. Results Of the patients,41 (50.6%) weighed 51-70 kg, and 45 (46.4%) were 21-23 years old. The age of acne onset was 20 years or younger. Most patients had a starting isotretinoin dose of 10-20 mg and an ending dose of 30-40 mg over six months. Ninety (92.8%) patients had not used isotretinoin in the past. Before treatment, AST was elevated in three (3.1%) patients, and ALT was elevated in two (2.1%) patients. In the last readings, AST was elevated in eight (8.2%) patients, and ALT was elevated in four (4.1%) patients. Conclusion The result of this study indicates that the incidence of high levels of AST and ALT with oral isotretinoin was low. So frequent laboratory monitoring is not recommended since the elevation was not associated with any morbidity and carries financial and emotional burdens. An exception is patients with higher body weight, males, and those whose acne started at age 16-19, in whom frequent monitoring may be considered for AST more than ALT.

Prospective study of the effects of isotretinoin and vitamin D levels on severe acne vulgaris.

Acne vulgaris (AV) is a common inflammatory skin condition associated with psychological and social distress. Its pathogenesis involves factors such as sebaceous hypersecretion and Cutibacterium acnes colonization. Vitamin D plays a crucial role in the pathogenesis of various inflammatory skin disorders, including AV, due to its immunomodulatory effects and involvement in keratinocyte growth and maturity. However, adequate sun exposure is required for optimal vitamin D synthesis. Isotretinoin (IOS), a vitamin A derivative, is a commonly used medication for severe acne, acting by binding to retinoid receptors. It can also form heterodimers with vitamin D receptors, potentially increasing vitamin D catabolism. Previous studies examining the impact of oral IOS on serum vitamin D levels have yielded inconsistent results. Therefore, this study aimed to assess changes in 25-hydroxy (OH) vitamin D serum levels in individuals with severe AV before and after IOS treatment. One hundred patients with severe AV were enrolled, each receiving 0.75 mg/kg IOS treatment daily for 4 months. Serum 25 OH vitamin D levels were measured before, during, and after treatment. This study found a significant increase in serum 25 OH vitamin D levels among patients with severe AV following IOS treatment (p < 0.001). This study suggests that AV may negatively impact vitamin D synthesis, but IOS treatment appears to raise vitamin D serum levels in individuals with severe AV. Further research is needed to confirm the potential relationship between AV and vitamin D levels.

CO110 Systematic Literature Review and Network Meta-Analysis to Assess the Comparative Efficacy of Topical Fixed-Dose Combinations for Moderate to Severe Acne Vulgaris as Measured By Lesion Counts

CO110 Systematic Literature Review and Network Meta-Analysis to Assess the Comparative Efficacy of Topical Fixed-Dose Combinations for Moderate to Severe Acne Vulgaris as Measured By Lesion Counts

An audit of oral antimicrobial therapy against acne vulgaris NICE guidelines

Abstract Introduction The suggested therapy for moderate to severe acne vulgaris (AV) is a choice of lymecycline or doxycycline, in combination with topical adapalene and topical benzyl peroxide or topical azelaic acid. The guidelines state care should be taken when prescribing tetracyclines and topical retinoids in pregnancy given the potential harm.1 Antimicrobial resistance is rapidly emerging worldwide, endangering the efficacy of antimicrobial therapy which can be attributed to overuse and misuse of antimicrobials. This audit was conducted to identify inappropriate antimicrobial prescribing to allow discussion of therapy options with patients, thus reducing antimicrobial prescribing.2 Aim The audit objectives were to ensure appropriate therapy choice, therapy duration and contraception consideration in women of a childbearing age (WOCBA). To assess the aim of alignment to NICE guidelines, the following audit criteria and standards were used: 100% of patients should be prescribed appropriate therapy for moderate to severe AV; 100% of patients should receive less than 6 months of antimicrobial therapy; 100% of WOCBA should be considered for contraception at the initiation of tetracycline therapy. Methods A search was conducted on the VISION software on 20/01/2023 identifying which of the 25,000 patients registered as applied or permanent in a single GP practice had a repeat prescription issued for lymecycline or doxycycline in the previous 12 months. A pilot of approximately 10% of the sample size was successfully conducted, requiring no alterations to the search. Each included patient record was accessed individually for the required information and recorded under headings using Microsoft Excel. Patients without AV were excluded. The data were subjected to descriptive statistical analysis. As a clinical audit, this study did not require ethics approval. Results The search produced 157 results, leaving 102 patients after the exclusion criteria was applied. Of the included patients, 9.8% (n=10) were on the correct oral and topical therapy aligned with NICE guidance. In 90.2% (n=92) of patients, the duration of oral antimicrobial therapy was longer than 6 months. In 30.4% (n=17) of WOCBA, contraception was not prescribed at the initiation of tetracycline therapy. Discussion/Conclusion All set aims and objectives were met. A lack of adherence to NICE guidelines surrounding choice and duration of therapy was found. This may be attributed to unawareness of updated guidelines. Raising awareness of the guidelines and the implication of antimicrobial resistance may improve the inappropriate prescribing, thereby improving patient outcomes long term. The results suggested inadequate consideration of contraception, which was noted as a priority for being addressed within the practice. Healthcare professionals should be reminded of the potential teratogenicity caused by tetracyclines in pregnancy and the importance of thorough documentation.3 Further audits would be beneficial to address the limitations of the study, which included not knowing whether contraception had been discussed with WOCBAs on initiation, if not documented in the patient’s record, as the audit was conducted retrospectively. It would be useful to observe ordering patterns, issues of acute prescriptions, and the use of topical retinoids to WOCBA to further improve practice.

Serum Interleukin-19 Levels in Acne Vulgaris Patients of Varying Clinical Severity in Erbil City.

Background Acne vulgaris (AV) is a common multifactorial disorder affecting the pilosebaceous units. Research has shown that inflammation plays a crucial role in the pathogenesis of AV, including both inflammatory and non-inflammatory acne. Several studies have linked proinflammatory cytokines to AV; however, only a few have explored the correlation between interleukin-19 (IL-19) and AV. Our aim is to estimate the level of IL-19 in patients with AV compared to matched controls and to investigate the role of IL-19 in the pathogenesis of acne. Materials and methods This prospective cross-sectional case and control study includes 80 patients and 40 matched controls. Patients were divided into mild (20), moderate (40), and severe (20) groups based on their global acne score severity index. Detailed history and complete general and dermatological examinations were taken from each patient. Furthermore, 5 ml of blood was taken from all participants to assess the level of IL-19. Results IL-19 levels were significantly higher in patients with AV compared to matched controls. Furthermore, IL-19 concentrations were found to be proportional to the severity of acne, with the highest levels detected in patients with severe AV (p-value <0.005). Conclusion IL-19 levels in AV were significantly higher than in matched control. The difference was proportional to its severity. This might indicate IL-19 as an inflammatory marker and could potentially be related to AV.

A Systematic Literature Review and Network Meta-Analysis of Comparative Efficacy of Topical Fixed-Dose Combination Treatments for Moderate to Severe Acne Vulgaris

INTRODUCTION: Several topical and oral monotherapies/combination treatments are available for treating patients with moderate to severe acne vulgaris and a few are currently under review with the United States (US) Food and Drug Administration (FDA). Among these treatments, topical fixed-dose combinations (FDCs) are widely used in the US. No study has assessed the comparative efficacy of topical FDCs based on the treatment success endpoint of the proportion of patients achieving ≥2 grade reduction AND "Clear" or "Almost clear” status by week 12 on an Investigator's Global Assessment (IGA) or equivalent scales. The objective of this study was to conduct a systematic literature review (SLR) and network meta-analysis (NMA) to compare the efficacy of topical FDCs for the treatment of moderate to severe acne.&#x0D; STUDY DESCRIPTION: An SLR was conducted for identifying randomized controlled trials (RCTs), that included at least one topical FDC (currently approved/under review with FDA) arm, in academic (MEDLINE, Embase, Cochrane CENTRAL, PEDE, and NHS EED) and non-academic databases (HTA databases, conference abstracts databases, and trial registries). The search was conducted in May 2022, based on a pre-specified inclusion/exclusion criterion. RCTs included in the analysis evaluated acne severity using IGA or equivalent (Evaluator's Global Severity Score, Investigator’s Static Global Assessment) scales. A Bayesian network meta-regression was conducted, using the proportion of patients with moderate acne, inflammatory and non-inflammatory lesion counts at baseline as covariates to account for acne severity.&#x0D; RESULTS: Twelve Phase II/III/IV RCTs were identified from 5,159 citations comprising 8,349 patients across 8 treatment groups. The odds ratio for treatment success with topical FDC of clindamycin phosphate 1.2%, adapalene 0.15%, and benzoyl peroxide 3.1% (first triple agent FDC) gel was estimated to be 7.61 (95% Credible Interval: 4.44 –13.20) in comparison to Vehicle gel. Comparative effectiveness ranking demonstrated that the topical triple agent FDC gel was the most effective treatment with surface under cumulative ranking of 100%.&#x0D; CONCLUSION: Based on this SLR/NMA, the topical triple agent FDC of clindamycin phosphate 1.2%, adapalene 0.15%, and benzoyl peroxide 3.1% gel, which is currently under FDA review (PDUFA date 10/20/2023), was clinically superior to all other topical FDC treatments for moderate to severe acne vulgaris.

Efficacy and safety of isotretinoin Lidose®

Introduction. Acne is a common chronic inflammatory disease, which is accompanied by severe social stress and reduces the quality of life of patients. Isotretinoin is the gold standard for the treatment of severe and moderate forms of acne, and is also used when there is a risk of developing a post-acne symptom complex and when previous treatment methods are ineffective.Purpose of the study. To determine the effectiveness and safety of various isotretinoin regimens at a dose of 0.4–0.8 mg/kg in patients with moderate to severe acne vulgaris and in patients with adult acne.Materials and methods. A single-center, prospective, parallel, controlled study involved 139 patients with acne vulgaris and adult acne, who were divided into 3 groups. 72 patients with acne vulgaris of moderate severity according to the IGA scale (group A1) and 37 patients with adult acne (group B) received isotretinoin (Accutane) at a dose of 0.4 mg/kg/day (cumulative dose 100 mg/kg) for 8 months. 30 patients with severe forms of acne vulgaris (group A1) received Accutane at a dose of 0.8 mg/kg/day (cumulative dose 120 mg/kg) for 8 months. The study lasted 24 months. and consisted of 4 visits (1st visit, 4, 8 and 24 months), at each visit photocontrol was performed, the number of inflammatory and non-inflammatory elements was calculated, the DAI index and the degree on the IGA scale were determined.Results. All 139 patients achieved ‘clear’ or almost ‘clear’ skin according to the IGA scale after 8 months of therapy. There was also a statistically significant decrease in non-inflammatory and inflammatory elements in all groups after 4 and 8 months. (p &lt; 0.001). The total DIA score after 8 months was reduced in group A1 by 89.2%, in group A2 by 83.78% and in group B by 80.3%. Acne recurrence after 24 months was determined in five patients.Conclusions. Various regimens of Accutane for moderate and severe acne vulgaris, as well as adult acne, have demonstrated high efficacy and a favorable safety profile.

ACNE AND INSULIN RESISTANCE: A SYSTEMATIC REVIEW

Acne is a skin disorder that is characterized by persistent inflammation and involves the folliculopilosebaceous unit. It has an impact on a sizeable portion of the general population. Acne affects a disproportionate number of females and teenagers, especially those between the ages of 15 and 24, who are most susceptible to the condition. In recent times, there has been seen to be a growing interest in the possible connection between acne and insulin resistance (IR). This attention has been seen, and it is appreciated. It would appear that IR has a strong connection to acne, which is a persistent skin condition that can lead to inflammation. Research has been conducted on a wide variety of etiopathological factors that have been associated with the progression of IR. It would appear that obesity is one of the most common. Additionally, it would appear that factors such as chronic inflammation, hypertriglyceridemia, low HDL serum concentration, mitochondrial dysfunction, gut microbiota, and the excess activity of antagonistic hormones such as cortisol, glucagon, and thyroid hormones all play a significant role in the development of this condition. We identified a linkage between insulin resistance and severe acne vulgaris, which was reported to have a positive link with insulin resistance. On the basis of these findings, it is a legitimate assumption to hypothesize that medications that are now utilized for the treatment of insulin resistance would also be helpful for the treatment of severe acne vulgaris.

Evaluation of the Effect of Oral Isotretinoin on the Level of Serum YKL40 in Acne Vulgaris Patients: A Cross-Sectional Case-Control.

In the entire world, acne vulgaris (AV) is the most prevalent skin condition. Approximately 9.4% of people worldwide have acne vulgaris. This study compared the blood levels of chitinase 3-like protein 1 (YKL-40) in acne vulgaris patients before and after oral isotretinoin therapy. The design of the study was cross-sectional case-control. Forty patients with moderate to severe acne vulgaris and twenty healthy participants participated in this study. Using the Global Acne Grading System (GAGS) score, patients with acne vulgaris were evaluated both before and after concluding their treatment. Using the enzyme-linked immunosorbent assay (ELISA), the serum levels of YKL-40 were measured before and after oral isotretinoin therapy in healthy controls and acne patients. Patients with acne vulgaris had considerably greater serum levels of YKL-40 than healthy control subjects (p 0.001) did. After three months of oral isotretinoin medication, the GAGS score and blood levels of YKL-40 in acne vulgaris patients both significantly decreased. The conclusion of this study was that reducing the blood levels of YKL-40 and the GAGS score in patients with acne vulgaris who took oral isotretinoin for three months was a crucial strategy.

Adapalene Gel Therapy in Patients with Moderate to Severe Acne Vulgaris

Acne is a chronic inflammatory disease of pilosebaceous units. Topical Adapalene is the most effective despite the availability of various treatments. Abnormalities in plasma lipids are recognized side effects of Adapalene therapy. Minimal reports compare the lipid changes in intermittent and continuous Adapalene treatment. To evaluate the alteration in lipid profile before, during, and after constant/ intermittent topical Adapalene therapy. One hundred patients with moderate to severe acne were randomly assigned to two treatment regimens. Serum levels of lipids were measured at baseline, 4wk, 8wk, 12wk, 16wk, and at the end of the treatment. A significant increase in cholesterol, triglyceride, and LDL concentration and a decrease in HDL levels in a continuous regimen beyond the normal range but not requiring any treatment interruption compared to intermittent therapy. In intermittent therapy, the cholesterol, triglyceride, and LDL concentration increase was within the normal range. Intermittent Adapalene therapy was clinically equally effective, with lesser effects on serum lipid levels and cost than continuous Adapalene therapy.

Burden of treatment in severe acne vulgaris

AbstractBackgroundAcne is associated with a significant burden of disease related to the visual impact of facial lesions, symptoms such as pain, and sequelae such as scarring. However, little research has been performed on the acne‐specific burden of treatment (BOT), defined as the workload of healthcare as well as its impact on functioning and well‐being.ObjectivesThe aim of this study was to examine the BOT of moderate‐severe acne.MethodsA prospective study was performed in our tertiary dermatology department. Patients attending the dermatology department with moderate‐severe acne (defined as an Investigator's Global Assessment of acne severity of 3 or 4) were invited to complete a validated BOT questionnaire, modified for use in acne, with additional qualitative components.ResultsOf 50 patients, 68% were female, with a mean age of 22.6 years (range 16‐45 years). Most (82%, n = 41) patients were on isotretinoin, with 18% (n = 9) on oral antibiotics. The average BOT was 4.2/10 (range 0–8.2) for topical therapies, 4.5/10 (range 2.7–6.8) for oral antibiotics, and 3.8/10 (range 0.69–6.9) for isotretinoin. From qualitative statements, the greatest burdens reported with topical treatment were unpleasant sensations, skin sensitivity, skin dryness, and lack of efficacy; with antibiotic therapy were the requirement for long‐term treatment, limited efficacy, and side‐effects including gastrointestinal upset; and with isotretinoin therapy were cheilitis and xerosis, cost, and need for blood tests. However, 58% (n = 29) of patients believed their overall BOT was decreased with isotretinoin, and 18% (n = 9) felt that it was unchanged with isotretinoin, with statements such as “the side effects can be tough, but the result is definitely worth it.”ConclusionsThe BOT associated with oral isotretinoin is similar or lower to topical therapies and oral antibiotics. This should be taken into consideration when optimizing the care of patients with acne.

Efficacy of Isotretinoin in The Management of Enlarged Facial Pores in Moderate and Severe Acne Vulgaris Patients

Efficacy of Isotretinoin in The Management of Enlarged Facial Pores in Moderate and Severe Acne Vulgaris Patients

44255 Impact of acne on social functioning, emotional functioning, and activities of daily living(ADL) among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S: Race stratified analysis

44255 Impact of acne on social functioning, emotional functioning, and activities of daily living(ADL) among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S: Race stratified analysis

44232 Investigator Global assessment (IGA) of Acne Vulgaris and IGA Success among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S: Analysis of PROSES,by race and baseline AV severity

44232 Investigator Global assessment (IGA) of Acne Vulgaris and IGA Success among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S: Analysis of PROSES,by race and baseline AV severity

44248 Patient Reported Outcomes (PROs) assessed using Acne Symptom and Impact Scale (ASIS) among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S: Race stratified analysis of PROSES

44248 Patient Reported Outcomes (PROs) assessed using Acne Symptom and Impact Scale (ASIS) among patients with moderate to severe non-nodular Acne Vulgaris (AV) administered sarecycline in community practices across the U.S: Race stratified analysis of PROSES

Exploring The in vitro Efficacy of Psidium Guajava Leaf Oil Against Cutibacterium Granulosum

One potential approach to treat acne vulgaris is by utilizing Cutibacterium granulosum (C. granulosum) to break down the biofilm formed by Cutibacterium acnes (C. acnes). When using cosmeceutical products containing certain essential oils, as they may have the unintended effect of eliminating C. granulosum, leading to the potential development of more severe acne vulgaris in the long term. No data for Psidium guajava (guava) leaves oil against C. granulosum has been reported. Therefore, this study aimed to investigate in vitro antimicrobial activity of guava leaves oil against C. granulosum. This oil was extracted from the guava leaves by hydrodistillation using a clevenger-type apparatus. Then, the chemical compositions of this crude oil were identified by gas chromatography-mass spectrometry. The percentage yield of this essential oil was 0.13 ± 0.2% (w/w) on fresh weight basis. The major compounds were β-caryophyllene (25.50%), limonene (11.58%), caryophyllene oxide (3.43%),a-copaene (2.92%), 1,8-cineole (2.08%), and a-pinene (1.28%). This essential oil exerted a potent antioxidant capacity with the half maximal inhibitory concentration of 32.7 ± 0.3 mg/ml from 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Additionally, the essential oil of guava leaves showed the susceptibility of C. granulosum by agar disc diffusion method with 22 ± 0.2 mm of clear inhibition zone. This essential oil also possessed against C. granulosum with the minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) of 3.125 µg/ml and 6.25 µg/ml from the broth microdilution susceptibility test. From these findings, this essential oil exhibited notable synergistic antioxidant and antimicrobial activities against C. granulosum.

Modified red light 5-aminolevulinic acid photodynamic therapy versus low-dose isotretinoin therapy for moderate to severe acne vulgaris: A prospective, randomized, multicenter study

Modified 5-aminolevulinic acid photodynamic therapy (M-PDT) and isotretinoin (ISO) are effective treatments for moderate to severe acne vulgaris. To evaluate the efficacy and adverse effects of M-PDT and ISO for moderate to severe acne vulgaris. A multicenter, randomized clinical trial was conducted with participants randomly assigned to the M-PDT group (up to 5 weekly sessions following manual comedone extraction) or the ISO group (oral ISO, 0.5mg/kg/d for 6months) and followed up to 6-months after therapy. A total of 152 patients were allocated. The overall effective rates in the M-PDT group were significantly higher than the ISO group at 1month (67.74% vs 10.26%), whereas the opposite was the case 1month after treatment (75.81% vs 97.44%). Time to achieve 50% lesion improvement in the M-PDT group was significantly less than the ISO group (1 vs 8weeks). Overall, 70.67% of the ISO group patients experienced systemic side effects such as hepatotoxicity, whereas side effects were skin-limited in the M-PDT group. Limitations of this study included relatively low numbers of participants and high withdrawal rate. M-PDT offers a more rapid onset of improvement, comparable overall efficacy, good tolerability, and comparable durability of response compared with ISO.

Study on Acne Scarring and Its Relationship between Severity and Treatment of Active Acne: An Observational Study

Background: Incorrectly selected treatment or the presence of severe acne vulgaris can lead to the formation of atrophic scars. Objective: The purpose of the present study was to evaluate the acne scarring and its relationship between severity and treatment of active acne. Methodology: This was cross-sectional observation study was performed in the EW VM Health Bangladesh Ltd., Dhaka for a period of 6 months. Evaluation of the types, sites, and severity of acne scars was done, and details of the severity and treatment of acne were recorded. Patients of all age-groups presenting for treatment of acne scars were included in the study. Results: This study shows maximum (40%) were age group 31-40 years. Face was involved in all the patients with acne vulgaris, which included the cheeks (91%), forehead (43%), jaw (51%), chin (27.0%), and nose (16.0%). The most common type of lesion predominantly observed was comedones (54.0%) followed by papules (53.0%), pustules (43.0%), nodules (29.0%), and cysts (3.0%). It was observed that 21.0% were mild acne, 27.0% were moderate acne and 52.0% severe acne. In grading system of acne scaring, 19.0% were macular acne scar, 14.0% were mild acne scar, 28.0% were moderate acne scar and 39.0% were severe acne scar. Conclusion: This study found majority of patients with active acne delay treatment, which leads to increased acne scarring. Journal of Current and Advance Medical Research, July 2022;9(2):69-73