Seventh Class Research Articles

Penerapan Metode AHC (Agglomerative Hierarchical Clustering) untuk Klasifikasi Habitat Bentik di Desa pengudang, Kabupaten Bintan

Pengudang village is one of the villages located in Bintan Regency, Riau Islands Province which has a diverse marine ecosystem, in which there are various types of benthic habitat. This research aims to classify the benthic habitat in Pengudang Village and determine the diversity and characteristics of the bottom water substrate at the research location. This research was carried out on 10-11 June 2023 in Pengudang village with a total of 224 research points. This research uses data collection techniques using the random sampling method, then continues with data analysis using the AHC (agglomerative hierarchical clustering) method. The results of the research applying the AHC (agglomerative hierarchical clustering) method for the classification of benthic habitats resulted in six types of benthic habitats which, after being analyzed using the AHC method, resulted in seven habitat classifications that dominated all research points, the first class contained sand, dead coral and benthic habitat types. live coral, the second class is benthic habitat types of seagrass and sand, the third class is benthic habitat types of seagrass and sand, the fourth class is benthic habitat types of live coral, dead coral, seagrass, algae and sand, the fifth class is the type of habitat benthic live coral, dead coral, algae and sand, the sixth class of benthic habitat types of algae and sand, and the seventh class of benthic habitat types of live coral, dead coral and sand.

Dialogue embedded synectics model of teaching: a hybrid model for promotion of creativity

PurposeThe study aims to investigate the effect of the dialogue embedded synectics model of teaching on the creative thinking of students.Design/methodology/approachThe research design of the study was a nonequivalent control group design of quasi experimental research. This study collected data from 80 students in the seventh grade from two different government schools in Bathinda, Punjab, India, which were selected using a random method. The subjects of experimental group were taught by the investigator using the dialogue embedded synectics model of teaching and the subjects of control group were taught by their teacher using the traditional teaching method, i.e. the Herbartian method. The data collections were done using the creative thinking test developed by Baqer Mehdi (1995). The data analysis techniques used t-test.FindingsKey finding indicates that the dialogue embedded synectics model of teaching is effective in enhancing the creative thinking of students as compared to the traditional method.Originality/valueThe present work is unique in terms of development of an innovative pedagogy, i.e. the dialogue embedded synectics model of teaching, which has the potential to encourage students' creative thinking, a key concern for society in the 21st century. Therefore, it is suggested to conduct similar type of studies on this innovative pedagogy and this model of teaching may be used by teachers for enhancing creative thinking of seventh class students.

Studying the types of land Capability units and preparing the Capability map for some series of the North Tikrit Agricultural Project in Salah al-Din Governorate

The study aims to classify the land of the selected series to the types of land portability units and prepare a land portability map in the project north of Tikrit agricultural, where three series were selected by two hands for each series, namely the sdaeed series represented by pedon P 1 and P 2 , the Syneha series of p 3 and p 4 , and the Greesh series of p 5 and p 6 pedon, With an estimated area of (4,006.99) hectares, mostly Gypsium and limestone, permanent and temporary determinants have been adopted in the classification of the land Capability of study series. The climate factor, salinity and wind erosion are among the most influential determinants in determining an item under land susceptibility. Sub Capability land for the study series, and it was found through the results of the study that the Greesh series of p 5 .p 6 and an area (1379.62 hectares) was under the second class IIC4s, IIC4s3 for pedon 5 and 6 respectively , and the sadeed series represented by pedon P 1 and P 2 with an area (1255.86 h) under third class IIIC4s3 , IIIC4s2 for pedon 1 and 2 respectively , and the Syneha series of pedon p 3 and p 4 and an area (1371.51 hectares) under seventh class , V11C4s3e2 , V11C4s3e2 for pedon 3 and 4 respectively.

Peran Organisasi Santri Gabungan Anak Timur Sekitar Dalam Mengembangkan Ghirah Pembelajaran di Musthafawiyah Purba Baru

The purpose of this research is 1) to look at the history of the founding of the East Surrounding Children's Association organization in Mustafawiyah. 2) To see the role of the Surrounding Eastern Children's Association organization in maintaining the passion for learning in Musthafawiyah Purba Baru. This type of research is a qualitative research type with a qualitative descriptive approach method. Data collection techniques in this research are observation, interviews and documentation. Data analysis techniques use data reduction and data presentation. The data source in this research is the management of the Association of Surrounding Eastern Children (GATIS). The results of this research are 1) that in the East Surrounding Children's Association organization which was founded on September 28 2015, which was spearheaded by alumni and continued by the seventh class, among those who participated in establishing this organization were: Ilhan Syahfutra, Maulana Malik Ibrahim and Muhammad Yusuf. 2) The role of the surrounding Eastern Children's Association organization in developing Ghirah, they create several activities which can increase their enthusiasm for learning, including: Carrying out Mudzakarah, Special Guidance, holding competitions between fellow branch organizations, etc.

Establishment and characterization of a new class of adenylate cyclases (class VII ACs) in plants

Adenylate cyclase is the key enzyme in the synthesis of cAMP. Now, more and more plant genes which possessing AC function are being identified, but the classification of plant ACs has not yet been systematically studied and the relationship of plant ACs with other existing six classes ACs in animals and microorganisms is still unclear. In this study, we found that 7 of the 15 reported plant ACs with conserved CYTH-like_AC_Ⅳ-like domain were clustered into a group with high confidence (Group Ⅳ), while the other plant ACs were clustered into other three groups with no common domain. In addition, we also found that the Group Ⅳ plant ACs were grouped into an independent and specific class (Class VII), separated from the existing six classes of ACs. The Group Ⅳ plant ACs, compared to the existing six classes of ACs, own unique CYTH-like_AC_Ⅳ-like conserved domain and EXEXK signature motif, characteristic protein tertiary structures, specific subcellular localization and catalytic conditions. In view of the above, we regarded the Group Ⅳ plant ACs as the seventh class of AC (VII AC). This study does the systematic classification of plant ACs which could lay a foundation for further identification and study of the biological functions of the plant-specific VII ACs.

PEMBELAJARAN BAHASA INGGRIS BERBASIS BLENDED LEARNING DI ERA NEW NORMAL DENGAN MENGGUNAKAN “MISSING PIECES ACTIVITIES”

Since Covid-19 attacked several parts of the world, students are suggested to do distance learning. However, since New Normal era, students are allowed to do offline learning by implementing health protocol. This research is aimed to describe teaching method with blended learning model namely “Missing Pieces Activities” in English Subject for Seventh Class Junior High School 2 Bendungan Trenggalek-East Java. This teaching method involves various activities, they are: Missing Words for listening, Missing Small Thing speaking, and Missing Sentences for Reading. With this blended learning model, the activities are done by combining the online learning and offline learning. Source of data in this research is activities done by the students during the teaching and learning process. The data was collected through observation and interview. The finding of the research shows that students are more actively involved in the teaching and learning process. Further, they have higher motivation in learning due to the various activities they did in learning process. Therefore, this Missing Pieces Activities can be one of learning methods in New Normal Era to increase students’ activeness and motivation both in distance and offline learning.

REINFORCING STUDENTS’ MEMORY IN LEARNING ENGLISH VOCABULARY THROUGH EDUCANDY MEDIA

The research aimed to find out whether the implementation of Educandy Media reinforce students memory in learning English Vocabulary of seventh grade students atwsz SMPN 3 Papalang or not. This emphasizes on reinforce students vocabulary in learning process. This research used a pre-experimental method, with One Group Pretest posttest design consisting of six meetings and treatment. The number of samples is 20 students of seventh class. The data obtained by multiple choice questions in the form of noun material around. The results of calculation using SPSS 25 showed that the everage score of students’ vocabulary development was 27,00 in pre-test, and become 75,50 in post-test. Vocabulary development is supported by the t-test value which is greater than t-table value (4,687 > 1,729). Therefore, the alternative is accepted and null hypothesis is rejected. Based on analysis of the result, the researcher concluded that using Educandy media to reinforce students’ memory and improve the vocabulary of the SMPN 3 Papalang, Mamuju is effective in teaching English vocabulary.

TA`TSIRU ISTIKHDAAMU AL-WASIILAH AT-TA’LIMIYYAH LU’BAH AL-MURABBA’AT FII ISTII’AAB MUFRADAAT AL-LUGHAH AL-‘ARABIYYAH: DIRAASAH KAMIYYAH FII AL-MADRASAH AL-MUTAWASITHAH NURUL KASYYAF AL-ISLAMI BEKASI

The research was conducted in the middle school Noor Al-Kashf Al-Islami Bekasi in the second period of the academic year 2019-2020, starting from April 2020 to May 2020. Middle School Nur Al-Kashf Al-Islami Bekasi. The method used in this research is the experimental method. The community in this research includes all female students in the middle school, Noor Al-Kashf Al-Islami Bekasi, and the research samples are female students in the seventh semester, who number 70 students, and are divided into two classes, they are 35 students for the experimental class, and 35 students for the controlled class. In order to know the comprehension of the vocabulary of the Arabic language, the female students, the researcher used the final test, which is the written test. And the definition of this value after the tests are conducted, which is the normal test and the homogeneous test. As for the methods used to analyze the data, the t-test was used at the level of significance (0.05). Before doing the t-test, the researcher performs the natural test using Liliefors test. And the result of the normal test in the experimental class indicates that Lo (L account) is 0.136 and in the controlled class that Lo (L account) is 0.114 and L table for the experimental class is 0.886 (with samples of 35 students at the level of significance 0.05) and L table for the exact class is 0.886 (with samples of 35 students at the significance level 0.05). After knowing the normal test, it is indicated that Lo(L) is smaller than L. Accordingly, the table summarizes that the samples are normal. Without this, the homogeneous test uses the Bartlett test. From the result of the homogeneous test, 2X calculates 2,183>2X Table 3,841. Accordingly, the researcher summarizes that the data is homogeneous. In testing the hypothesis, the t calculation is 8.88 and the degree of freedom is 68. As for the t table of 1.67 at the level of importance (0.05), therefore the t calculation is 8.88 < t table 1.67, so the zero hypothesis (0H) is rejected, and the research hypothesis (1H) is accepted. In other words, there is a positive effect in the use of the educational method, the game of squares, in the comprehension of the vocabulary of the Arabic language among the students of the seventh class in the intermediate school, Nour Al-Kashf Al-Islami Bekasi. The result of the research indicates that the comprehension of the vocabulary of the Arabic language using the educational method, the game of squares, is higher and greater than the comprehension of the vocabulary of the Arabic language for students who were taught by the school without using the educational method, the game of squares.

Classification of spectral fine structures of Saturn kilometric radiation

Abstract. The spectral fine structures of Saturn kilometric radiation (SKR) are best investigated with the wideband receiver (WBR) of Cassini's Radio and Plasma Wave Science (RPWS) instrument, with which measured radio fluxes can be displayed in time–frequency spectra with resolutions of 125 ms and ∼0.1 kHz. We introduce seven different classes of SKR fine structures ranging from dots (one class for 0-dimensional objects) over lines (four classes of 1-dimensional objects being horizontal, vertical, or with negative or positive slope) to areal features (one class for 2-dimensional objects). Additionally, we define a seventh class containing special structures named according to their appearance in time–frequency spectra. These special features are named rain, striations, worms, and caterpillar and the latter two have never been described in the literature so far. Using this newly defined classification scheme, we classify features in spectra at low frequencies in the baseband of the 80 kHz WBR and at medium frequencies around 325 kHz. A statistic of the occurrence of various classes and sub-classes shows some notable characteristics: lines with a positive slope are much more common at medium frequencies than at low frequencies and vertical lines are almost absent at low frequencies. The particular fine structure of striations (group of narrowbanded lines with predominantly negative slopes) is quite common below 80 kHz but less common near 325 kHz. At these medium frequencies, the lines rather look like interrupted striations which we term with the name “rain”. We also find rare instances of striations with a positive slope and rare instances of absorption signatures within areal features. The newly introduced sub-classes of worms (lines oscillating in frequency) and caterpillars occur almost exclusively below 80 kHz. Caterpillars have a typical bandwidth of ∼10 kHz, a constant frequency below ∼40 kHz for several hours and they are mostly observed beyond distances of 10 Saturn radii. We discuss the implications of our findings in view of the many theories about spectral fine structures of auroral radio emissions.

DEVELOPMENT OF INTEGRATED SCIENCE LEARNING MODULES BASED ON PROBLEM SOLVING AND SCIENTIFIC LITERACY ON THE SUBJECT OF GLOBAL WARMING FOR VII GRADE JUNIOR HIGH SCHOOL STUDENTS

The scientific approach in the 2013 curriculum aims to improve intellectual abilities, especially students high level thinking skill, but in science learning, students thinking abilities to solve problems are still low and the application of science literacy is still not maximum. Developing an integrated science learning module based on problem solving and scientific literacy is one way to overcome this problem. The concept developed in this research is global warming. The aim of this research is to out science learning module valid and practical. In this study, the instrument used was a validation questionnaire that was filled in by two science education lecturers and two seventh class science teacher, while the practicality test was carried out by two science teachers and by students in a one to one and small group manner. The descriptive statistical analysis technique used in this study. Based on the data analysis conducted, the avarage validity value was 86,74. In the one to one stage it was 79,19, while according to the teacher and students the small group stage was 91,89 and 89,05. So in conclusion, the module developed is valid and practical for students to use as a source of independent learning.

Using The Picture and Picture Learning Strategy in Learning Writing Skill at Islamic State Junior High School 5 of Bojonegoro

Picture and Picture is one of the learning strategies that use picture media in education. This strategy is active, creative and fun. Writing skills is one of the important in Learning Arabic. However the students of seventh class Islamic state Junior High School 5 Bojonegoro have many difficulties in writing sentences or simple paragraphs, because they feel bored and learning strategies used low attractive . The input in this research is quantitative and the research method used is the experimental method . The objectives of the research are to find out the use of picture and picture learning strategy in teaching writing skill in MTsN 5 Bojonegoro and to calculate the measurement of effectiveness of using picture and picture learning strategy in developing writing skill in MTsN 5 Bojonegoro. The input in this research is quantitative and the research method used is the experimental method. The results of this research are that the use of the picture and picture strategy is “effective”, considering the result of the castration t: 11.75 greater than the degree of t-tables at the 1% level (2,000), and greater than the degree of t-tables at the 5% level (2,660). ) . By that, (Ha) are acceptable, and (H0) is rejected, meaning that the use of the Picture and Picture strategy is "effective".

The Effect of Online Learning on Mathematics Value of Seventh Class Students in Bulu China Swadaya SMPS

This study aims to determine (1) learning outcomes in mathematics, (2) the effect of WhatsApp media on students' mathematics learning outcomes. This research is quasi-experimental. The population in this study were students of class VII SMP, totaling 36 students. In this study, the sample used was total sampling in which all populations were sampled in this study. The design used in this study was the pre-test post-test control group design. The research instrument was a learning outcome test and a learning difficulty questionnaire. To test the hypothesis using a paired sample t-test. The results of this study indicate that the post-test mean score that has been tested in the experimental class is 83.50. This means that the learning outcomes in the experimental class are seen by using the paired sample t-test of 0.006 <0.05, which means that there is a significant effect between the average value before treatment (pre-test) and the average value after treatment (post-test).

THE IMPLEMENTATION OF INQUIRY MODELS TO IMPROVE ACCURACY AND STUDENT LEARNING ACHIEVEMENT (Case Study on science subject of seventh class in SMPN 05 Lebong )

This study purpose to describe the implementation of the inquiry model in science learning to improve accuracy of students in seventh class in SMPN 05 Lebong, describing the implementation of the inquiry model achievement in seventh class in SMPN 05 Lebong, describing the effectiveness of the implementation inquiry model in improving student science learning achievement of seventh class in SMPN 05 Lebong the research conducted classroom action research combined with quasi- experiment. Subject of this studywas seven one PTK class, seven three experimental class, while class seven four is control class. The instruments used are observation and test sheets. Data analysis techniques use the average formula and t-test, while the observation data are analyzed by difference in score and range of values for each criterion. The results of the study show that the

أبواب نحویة بین الأصل والفرع دراسة وصفیة تحلیلیة

الملخص : اجتهد النحويون في وضع أصول النحو العربي منذ بداية الطور الأول البصري إلى أن انتهت جميع أبوابه في الطورين الثاني والثالث من أطوار النحو على يد الطبقة السابعة البصرية والخامسة الکوفية, فشمل النحو أبواب الصرف کذلک , ثم وزعوا هذه الأبواب على ترتيب ماله الأولوية من الأصول, و الفروع التي تحمل عليها , مبتدئين بالأسماء والأفعال والحروف, فجرى الاتفاق بينهم على أن الاسم هو الأصل لتمکنه وقبوله حروف الجر والتنوين, والإسناد, النداء والتعريف بأل , والفعل والحرف فرعان, ثم الحديث عن الإعراب والبناء في الأسماء فجرى القول على أن المعرب هو الأصل, لأنه؛ الأقوى وأصل الإعراب الضم , وبعد ذلک تناولوا أصولية الجموع وفرعيتها؛ فاتفقوا على أن التذکير هو الأصل والتأنيث فرعا عليه. أما أقوالهم عن أصولية الأفعال وفرعيتها, فقد قسموا الأفعال إلى ثلاثة أقسام باعتبار الزمن : ماض حاضر ومستقبل , ثم اختلفوا في أيهم أصل ومقدم . وناقشت اختلافاتهم في الأصول والفروع واختلافهم في الفعل والمصدر أيهما مشتق من الآخر , فذهب البصريون إلى أن الفعل مشتق من المصدر لخفته , وذهب الکوفيون إلى أن المصدر مشتق من الفعل لدلالته على الحدث , وبعد ذلک فصلوا القول عن اهتمامهم بالأصول و إهمالهم الفروع ,مستشهدين بآيات الذکر الحکيم والشعر العربي , ويشمل کلامهم مراعاة مراجعة الأصل الأقرب دون الفرع وقد أفاضوا في الدراسة عن انحطاط الفروع عن رتب الأصول بقولهم: إن الفرع أحط رتبة من الأصل وتناولوا الأصول المنصرف عنها إلي الفروع وما جاء شاذا منها للضرورة. Abstract The grammarians worked hard to establish the fundamentals of Arabic grammar from the beginning of the first stage at Basra until all its rules were finished in the second and third stages of the grammar by the seventh class at Basra and fifth class of Koufic. The theories of Arabic grammar at that time included the structure chapters, also . After that they classified all these chapters according to their necessity and priority into the fundamentals and the branches starting with nouns, verbs and letters. They agreed that the noun is the fundamental and this because it can be easily used and accompanied with prepositions, Noonation (Nunation) (tanween) and the definite article solar laam lunar laam . They also agreed that verb and the letter are two branches. Then they talked about the verbal expressions (indicative, subjunctive and jussive moods) and the structure of nouns and said that the verbal expressions noun is the origin because it is the strongest and the origin of the mood signs is Damma . After that they talked about the origin and the branches if the different kinds of the plurals and agreed that the masculinity is the origin and the feminity is a branch. But according to what the grammarians said about the origin and the branches in verbs: - They sorted the verbs to three types the simple past , the simple present and the simple future and do not agreed which one of them is the origin and has the priority. Then Mohammad Bin Al Serag said that the present simple is the origin and has the priority. Also, the grammarians had different opinions about the origins sources and the branches of the verb and the infinitive : -Which one is derived from the other? The Basra grammarians said that the verb is derived from the infinitive that is because it is lighter easier in use and pronunciation but the Koufic grammarian said that the infinitive is derived from the verb because it explains what is happening clearer. After that, they classified the fundamentals and the branches according to the verses quoted from of the Holy Quran and the Arabic poetry. They also put in their consideration reviewing the near origin not the branch. They went deeply in study about degeneration of the branches comparing with the origin saying The branch is downgraded from the origin. and they used the origin that are not commonly used than the used branches and the odd ones for necessity.

INVESTIGATION OF THE DEVELOPMENT OF CREATIVITY IN SECONDARY SCHOOL CHILDREN: A FOUR-YEAR LONGITUDINAL STUDY

In this study, which is planned to observe the advancement of creativity in secondary school children in the sixth, seventh and eighth classes starting from the fifth class, the relational scanning model which is one of the describe approachs was used. This is as well lengthwise research. The population of the study contained of children attending the first grade of secondary schools in Yozgat (Turkey) city center in 2015–2016 academic year. The sample of the study contained of 154 children (78 girls, 76 boys) attending two fifth grade branches in three secondary schools selected from these secondary schools. In the sixth grade, the number of samples decreased to 147 (72 females, 75 males), 137 in the seventh grade (68 females, 69 males) and 132 (65 females, 67 males) in the eighth grade. The analyzes were performed on data collected from 132 children in the eighth grade. General Information Form and Torrance Tests of Creative Thinking (Figure Form A and Form B) were used as data collection tools. In the analysis of the data, descriptive statistics, frequency, analysis of variance for rehearced measurements and T-Test for unrelated measurements were performed. Hence of the study, it was seen that the creative thinking scores of the children in the fifth, sixth, seventh and eighth classes differed in all sub-dimension scores and total creativity scores. In the fluency sub-dimension, the scores obtained in the fifth grade and sixth, seventh and eighth classes differed in favor of the sixth, seventh and eighth classes, respectively. In the sixth grade, the difference between the scores received in the seventh and eighth classes advantage of the scores obtained in the seventh and eighth classes, respectively. Moreover, the difference between the scores obtained in the seventh class and the scores taken in the eighth class were found advantage of the scores obtained in the eighth grade. In the sub-dimension of originality, there was a difference between the scores obtained in the fifth grade and the scores obtained in the seventh and eighth classes, respectively, in favor of the scores obtained in the seventh and eighth grades. It was found that there was a differentiation between the scores obtained in the seventh grade, and the scores obtained in the eighth grade in the seventh and eighth classes, respectively. It is seen that there is a statistically significant difference between the scores obtained in the fifth, sixth and eighth grades in the abstraction of headings advantage of the scores obtained in the seventh grade. In the enrichment sub-dimension, it was found that the scores obtained in the fifth and sixth grades differed significantly from the scores obtained in the eighth grade in favor of the scores obtained in the fifth and sixth grades. In the sub-dimension of resistance to early closure, it was observed that there was a difference between the scores obtained in the fifth, sixth and eighth grades and the scores obtained in the seventh grade advantage of the scores obtained in the seventh grade. In the total creativity scores, there was a difference between the scores obtained in the fifth grade and the scores obtained in the sixth class advantage of the ratings obtained in the sixth grade. It was determined that the scores obtained in the fifth sixth and eighth grades differed significantly advantage of the scores obtained in the seventh class (p <.05). It was determined that the total creativity rating of the children participator in the survey in the sixth class and the early closure resistance subscale scores obtained in the eighth grade differed according to gender (p <.05).

The Effect of the Landa Model in Achievement to chemistry Subject in the Seventh Class basic of Female Pupils

The Effect of the Landa Model in Achievement to chemistry Subject in the Seventh Class basic of Female Pupils

EFFECTS OF ACTIVITY-BASED TEACHING AND TRADITIONAL METHOD OF TEACHING MATHEMATICS IN THE AREA OF KNOWLEDGE AT ELEMENTARY LEVEL

The aim of this research was to find out the effects of activity-based teaching and traditional method of teaching Mathematics in the area of Knowledge at Elementary Level. The research was experimental based on pre-test, post-test control group design. Two units of geometry were selected from seventh class Mathematics for this research. Population of the research study was all students of seventh class from GGHS Bhedian Pattoki, District Kasur, Punjab (Pakistan). For selection of sample a pre-test was administered to all (84) students of class seventh in Govt. Girls High School Bhedian Pattoki District Kasur except twenty students. Thirty students (each) were assigned randomly to experimental and control group on the basis of pre-test matching scores. Both tests were developed from the seventh class Mathematics Book for the compilation of data. Tests were administered keeping the domain of knowledge in view. Selected unit 10 and unit 12 from seventh class Mathematics Book prescribed by Punjab Text Book Board were taught to both groups (experimental and control) for the time of eight weeks. Activities were used for experimental group only and other group was taught traditionally. Time for the teaching Mathematics was 40 minutes daily to each group. Independent sample t-test was applied on the pre-test and post-test scores to check whether there is difference in the performances of two groups in the domain of knowledge. It was concluded that there was significant difference in mean achievement scores in the area of knowledge taught by activity-based teaching. Activity based teaching was recommended for other areas of cognitive domain. It was recommended that activities may be used for each subject and for every class up to elementary level.

Leveraging on Active Site Similarities; Identification of Potential Inhibitors of Zinc-Finger and UFSP domain Protein (ZUFSP).

ZUFSP (Zinc-finger and UFSP domain protein) is a novel representative member of the recently characterized seventh class of deubiquitinating enzymes (DUBs). Due to the roles DUBs play in genetic instability, they have become a major drug target in cancer and neurodegenerative diseases. ZUFSP, being a DUB enzyme has also been implicated in genetic stability. However, no lead compound has been developed to target ZUFSP. Therefore, in this study, we used a combined drug repurposing, virtual screening and per-Residue Energy Decomposition (PRED) to identify ZUFSP inhibitors with therapeutic potential. 3-bromo-6-{[4-hydroxy-1-3(3-phenylbutanoyl)piperidin-4-yl]methyl}-4H,5H,6H,7H-thieno[2,3- C]pyridine-7-one (BHPTP) which is an inhibitor of USP7 was repurposed to target ZUFSP. The rationale behind this is based on the similarity of the active between USP7 and ZUFSP. PRED of the binding between BHPTP and ZUFSP revealed Cys223, Arg408, Met410, Asn460, and Tyr465 as the crucial residues responsible for this interaction. The pharmacophoric moieties of BHPTP responsible for this binding along with other physiochemical properties were used as a filter to retrieve potential ligands. 799 compounds were retrieved, ZINC083241427, ZINC063648749, and ZINC063648753 were selected due to the binding energy they exhibited. Cheminformatics analysis revealed that the compounds possess high membrane permeability, however, BHPTP had a low membrane permeability. Furthermore, the compounds are drug like, having obeyed Lipinski's rule of five. Taken together, findings from this study put ZINC083241427, ZINC063648749, and ZINC063648753 as potential ZUFSP inhibitor, however, more experimental validation is required to unravel the mechanism of actions of these compounds.

Hydrological classification and performance of Himalayan springs in climate change scenario – a case study

AbstractThe present study was conducted to evaluate 33 springs' hydrology (discharge and yield estimation) of Chandrabhaga and Danda watersheds of Uttarakhand, India. The springs were classified using Meinzer method and evaluated the relative performance for rejuvenation strategy. It was found that most of springs fall in sixth and seventh class order with flow rate 6.5 to 65.5 and 0.8 to 6.5 m3·day−1, respectively. The relative performance of springs were analyzed based on four methods: (i) spring flow variability, (ii) normalized spring flow (short and long duration), (iii) rainfall spring flow lag and (iv) spring flow gradient. The relative results of springs were analyzed on a scale of 0–5. The Chandrabhaga springs 01, 03, 4B, 05, 06 and 13 were found to be relatively good on a scale value of 4 out of 5 as compared to springs 4A, 07, and 10A with a scale value of 1. For the Danda watershed, the relative performance of springs 4A and 28 found on scale value of 5 and springs 4B, 11 and 20 with a scale value of 4 are relatively good compared to springs 02, 06, 07, 15 and 17. The cumulative flow of spring showed a linear response with cumulative rainfall for the period of June to September (monsoon period). The spring-shed was delineated and evaluated for optimization for the maximum efficiency, spring flow, ratio of area and relief versus maximum spring flow yield. The results revealed that the quantification of water fluxes for water balances, storage of groundwater and development of mathematical models can be used for sustainable water resources development and to revive the mountain springs which helped the adverse impacts of climate change.

Relationship of Teacher’s Content Knowledge on Fraction Topic Toward Student Performance

The aim of this study was to describe the relationship between teacher content knowledge and student performance in Fraction. This study used the mixed method that provided Content Knowledge test for fifteen teachers who taught the seventh class. The test consists of multiple choices to measure facts and procedures, knowledge of concepts and relationships, and knowledge of generalization. The study was divided into two phase, Quantitative phase and Qualitative phase. The Quantitative phase, teachers were mapped in two different levels, low and high based on score of Content Knowledge test. Two samples were classified into low level and high level. Furthermore, two groups/classes of the teacher samples were analyzed using Chi-Square test to investigate the relationship between teachers and student performance. The Qualitative phase of the study were included into three stages: (1) teacher interview, and (2) Student Problem solving, (3) description of the relationship of teacher’s content knowledge and student learning performance. The results of the study showed that the Teachers content knowledge in Fraction were affected to student performance, in addition, there were also similarities in the pattern of student performance tests on fraction and the teacher’s answers based on the results of the CK test.