As large cities are continually being developed around coastal areas, structural damage due to the consolidation settlement of soft ground is becoming more of a problem. Estimating consolidation settlement requires calculating an accurate compressive index through consolidation tests. However, these tests are time-consuming, and there is a risk of the test results becoming compromised while preparing and testing the specimens. Therefore, predicting the compression index based on the results of relatively simple physical property tests enables more reliable and accurate predictions of consolidation settlement by calculating the compression index at multiple points. In this context, this study collected geotechnical data from the soft ground of Korea’s south coast. The collected data were used to construct a dataset for developing a compression index prediction model, and significant influencing factors were identified through Pearson correlation analysis. Simple and multiple linear regression analysis was performed using these factors to derive regression equations, and compression index prediction models were developed by applying machine learning algorithms. The results of deriving the significance of the influencing factors from the developed compression index prediction model showed that natural water content was the most significant factor in predicting the compression index. By collecting a significant amount of high-quality data and using the compression index prediction model and the model construction process proposed in this study, more accurate predictions of the compressive index will be possible in the future.