Setting Time Of Magnesium Phosphate Cement Research Articles

A bioactive magnesium phosphate cement incorporating chondroitin sulfate for bone regeneration

Magnesium phosphate cement (MPC) has been evaluated as an inorganic bone filler due to its favorable biocompatibility, biodegradability, rapid setting, high initial strength, and osteogenic potential. However, the setting time of MPC is so rapid that it makes it difficult to use in practice, and the clinical properties of MPC could be further be improved by adding bioactive materials. Here we developed novel bioactive chondroitin sulfate (CS)-MPC composites (CS-MPCs) by incorporating different amounts of CS into MPC. The compositions, microstructures, and physiochemical properties of CS-MPCs and their induced in vitro cellular responses and in vivo bone regeneration properties were evaluated. CS-MPCs had a longer setting time, lower hydration temperature, higher compressive strength, and more neural pH than MPC. CS-MPCs demonstrated similar degradation ratios relative to MPC in Tris-HCl solution. CS-MPCs promoted pre-osteoblast cell proliferation, attachment, and differentiation in vitro and enhanced bone formation surrounding implants in vivo. In conclusion, through CS modification, our novel CS-MPCs have improved physiochemical properties that enhance compatibility in vitro and bone regeneration in vivo, making them attractive materials for bone regeneration.

Effect of Cr (III) on hydration, microstructure of magnesium phosphate cement, and leaching toxicity evaluation.

The pollution caused by chromium and its compounds has caused severe harm to the environment, and waste stabilization/solidification containing these contaminants by magnesium phosphate cement (MPC) is one of the best ways to address this problem. If the mechanism between Cr3+ and MPC can be understood, it will significantly improve the latter's solidification performance with respect to ameliorating Cr pollution. In this paper, the compressive strength, microstructure, pH in the process of sample hydration, and leaching toxicity of solidified forms were studied by adding various amounts of Cr3+ into MPC. The setting time of MPC decreased at first and then increased as the Cr3+ concentration increased. The added Cr3+ reacted with the phosphate ions to form mineral phases, which changed the MPC matrix structure. The matrix's compressive strength was higher when the M/P ratio (MgO/KH2PO4 mass ratio) was smaller. When the concentration of Cr3+ was constant, and the M/P ratio was low (< 4:1), the matrix's compressive strength increased as the M/P ratio increased. The presence of Cr3+ changed the system's pH and affected the hydration products' morphology; this trend strengthened as the Cr3+ concentration increased. The highest leaching concentration of Cr3+ was 0.255mg/L, and the concentration decreased as the M/P ratio decreased. During solidification, the appropriate proportion of MPC can be selected according to the concentration of Cr3+ to achieve better solidification performance.

Influencing Factors of Setting Time about Magnesium Phosphate Cement

Because the setting time of magnesium phosphate cement (MPC) was too quick, its further application was restricted. Influence factors about magnesium phosphate cement setting time are summarized and the influence laws are studied in the paper. The results show that with the increase of phosphorus to magnesium ratio (P/Mg) or boron to magnesium ratio (B/Mg), the setting time is both obviously prolonged. The effect of water to binder ratio (W/C) on the setting time of MPC has an optimal point. As the specific surface area increases gradually, the setting time of MPC is greatly shortened. Although fly ash has effect on setting time of MPC, the effect is very small. At the same time, the setting time is closely related with environmental temperature, the pH value of the system and mixing volume.

Study on Preparation and the Setting Time of Magnesium Phosphate Cement

This paper mainly researched on preparation and the setting time of Magnesium Phosphate Cement (MPC). The method of orthogonal experiment was adapted to determine the best ratio of MPC, and change the content and types of the material according to the influence of various factors, so as to get the longer setting time of MPC. The results showed that, when the water cement ratio is 0.12, the factors significantly influencing the setting time is magnesium phosphorus ratio (M/P), fly ash and borax. The optimal mixture ratio was obtained through the orthogonal analysis, namely M/P is 3/1, borax content is 16%, and the amount of fly ash is 40%. When M/P is 1/1 and 2/2, borax content is not more than 22%, and the amount of fly ash was less than 60%, the longer setting time of MPC can be produced.