ABSTRACT This paper aims at investigating influencing factors of block chain on collaborative product innovation (CPI) performance in the manufacturing supply chain. First, according to the application value of block chain in CPI and the CPI characteristics in manufacturing SC, this paper proposes a research model based on the innovation diffusion theory. Second, a set of hypotheses were derived from the research mode and a questionnaire was deployed to collect data in Chinese manufacturing enterprises. Data analysis was performed by using the AMOS modeling method based on a total of 373 valid surveys. Findings show a positive linear chain relationship between block chain, supply chain’s collaborative innovation capability, and supply chain’s CPI performance. Moreover, block chain capability is diffused into CPI capability for indirectly promoting the supply chain’s CPI performance. This study can put forward theoretical guidelines for manufacturing enterprises to grasp the strategic significance of block chain in product innovation activities.