The direct determination of exterior orientation parameters (EOP) of aerial images via integration of the Inertial Measurement Unit (IMU) and GPS is often used in photogrammetric mapping nowadays. The accuracies of the EOP depend on the accurate parameters related to sensors mounting when the job is performed (offsets of the IMU relative to the projection centre and the angles of boresigth misalignment between the IMU and the photogrammetric coordinate system). In principle, when the EOP values do not achieve the required accuracies for the photogrammetric application, the approach, known as Integrated Sensor Orientation (ISO), is used to refine the direct EOP. ISO approach requires accurate Interior Orientation Parameters (IOP) and standard deviation of the EOP under flight condition. This paper investigates the feasibility of use the <i>in situ</i> camera calibration to obtain these requirements. The camera calibration uses a small sub block of images, extracted from the entire block. A digital Vexcel UltraCam XP camera connected to APPLANIX POS AV<sup>TM</sup> system was used to get two small blocks of images that were use in this study. The blocks have different flight heights and opposite flight directions. The proposed methodology improved significantly the vertical and horizontal accuracies of the 3D point intersection. Using a minimum set of control points, the horizontal and vertical accuracies achieved nearly one image pixel of resolution on the ground (GSD). The experimental results are shown and discussed.