The main purpose of this research is to investigate a mathematical model of nanofluid passing through a stretching sheet having titanium dioxide (TiO2), copper oxide (CuO), and carbon nanotubes (CNTs) as nanoparticles, and sodium alginate is used as a base fluid. The present model can be very useful for numerous fields like Bioengineering, science, and technology. The main reason for using titanium dioxide, copper oxide, and carbon nanotubes nanoparticles as nanomaterials they have many applications in several areas. Moreover, impacts of non-linear thermal radiation and entropy generations are taken into account. By utilizing the similarity transformation technique given system of governing PDEs are transformed into a set of ODE. Then dimensionless equations are numerically tackled via the Keller box method a built-in function in the computer tool MATLAB. To support the present study, physical and numerical interpretations of involved parameters against velocity, temperature, and entropy generation profiles are also presented. From the analysis it is concluded that the combination of a magnetic field and suction reduces the rate of fluid mobility due to the synchronization of the magnetic and electric fields generated by the formation of the Lorentz force. In addition, boosting the thermal radiation parameter raises the present authors' heat transfer rate. The velocity profile drops when the Casson parameter is raised, but the heat and entropy production profiles grow. When the porosity parameter is increased, the velocity profile falls, and the heat and entropy production profiles rise. Additionally the temperature distribution is boosted up with increasing the values of nanoparticles volume fraction. The good agreement between current results and published data is observed. It is necessary to investigate the thermophysical characteristics of the magnetite nanofluid (titanium dioxide, copper oxide, and carbon nanotubes-sodium alginate nanofluid) under various situations. The MHD flow of nanofluid is significant because of its wide range of industrial uses, including flows over the tips of rockets, planes, submarines, and oil tankers. The novelty of this work is to scrutinize the MHD flow and heat transfer analysis of a nanofluid towards a stretched surface. The features of magnetite nanofluid (titanium dioxide, copper oxide, and carbon nanotubes-sodium alginate nanofluid) under entropy generation, thermal radiation and velocity slip are investigated. All of this contributes to the work's uniqueness and novel.