Mapping of rock types, structural geology, and hydrothermal alteration, supported by geochronology and thermochronology, sheds light on the original spatial relationships of hydrothermal systems to intrusions in the northern Shoshone Range in north-central Nevada. Rocks in the Hilltop district are tilted ~35–40°E, as indicated by orientations of flattened pumice fiamme and bedding in sedimentary rocks along a single set of presently low-angle normal faults that initiated at 60–70°W dips. New U-Pb zircon geochronology from two sets of dikes in the Lewis district could suggest late Eocene–early Oligocene extension, but definitive crosscutting relations are lacking to demonstrably support this potential earlier period of normal faulting. Reinterpretation of previously reported apatite fission-track cooling ages with a new palinspastic restoration in the Lewis mining district concurs with middle Miocene extension as documented to the south at the Caetano caldera; however, the depth of burial of the Lewis district—and thus the significance of the apatite fission-track cooling ages—is uncertain. The comparable orientations and tilting history, supported by fault scaling relations, suggest that the temporally coincident extension in the Caetano caldera to the south represents the along-strike continuation of the same system of normal faults as in the Hilltop and Lewis districts, with changes in observed offset, percent extension, and fault spacing attributed to the gradual tipping out of the fault system northward.