A fuzzy radial basis adaptive inference network (FRBAIN) is proposed for multichannel time-varying signal fusion analysis and feature knowledge embedding. The model which combines the prior signal feature embedding mechanism of the radial basis kernel function with the rule-based logic inference ability of fuzzy system is composed of a multichannel time-varying signal input layer, a radial basis fuzzification layer, a rule layer, a regularization layer, and a T-S fuzzy classifier layer. The dynamic fuzzy clustering algorithm was used to divide the sample set pattern class into several subclasses with similar features. The fuzzy radial basis neurons (FRBNs) were defined and used as parameterized membership functions, and typical feature samples of each pattern subclass were used as kernel centers of the FRBN to realize the embedding of the diverse prior feature knowledge and the fuzzification of the input signals. According to the signal categories of FRBN kernel centers, nodes in the rule layer were selectively connected with nodes in the FRBN layer. A fuzzy multiplication operation was used to achieve synthesis of pattern class membership information and establishment of fuzzy inference rules. The excitation intensity of each rule was used as the input of T-S fuzzy classifier to classify the input signals. The FRBAIN can adaptively establish fuzzy set membership functions, fuzzy inference, and classification rules based on the learning of sample set, realize structural and data constraints of the model, and improve the modeling properties of imbalanced datasets. In this paper, the properties of FRBAIN were analyzed and a comprehensive learning algorithm was established. Experimental validation was performed with classification diagnoses from four complex cardiovascular diseases based on 12-lead ECG signals. Results demonstrated that, in the case of small-scale imbalanced datasets, the proposed method significantly improved both classification accuracy and generalizability comparing with other methods in the experiment.
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