Group Set Research Articles

Sidon Sets in Algebraic Geometry

Abstract We report new examples of Sidon sets in abelian groups arising from generalized Jacobians of curves, and discuss some of their properties with respect to size and structure.

Convergence of Fourier truncations for compact quantum groups and finitely generated groups

We generalize the Fejér-Riesz operator systems defined for the circle group by Connes and van Suijlekom to the setting of compact matrix quantum groups and their ergodic actions on C*-algebras. These truncations form filtrations of the containing C*-algebra. We show that when they and the containing C*-algebra are equipped with suitable quantum metrics, then under suitable conditions they converge to the containing C*-algebra for quantum Gromov-Hausdorff distance. Among other examples, our results are applicable to the quantum groups SUq(2) and their homogeneous spaces Sq2.

On the existence of k $k$‐cycle semiframes for even k $k$

AbstractA ‐semiframe of type is a ‐group divisible design of type in which is the vertex set, is the group set, and the set of ‐cycles can be written as a disjoint union where is partitioned into parallel classes on and is partitioned into holey parallel classes, each parallel class or holey parallel class being a set of vertex disjoint cycles whose vertex sets partition or for some . In this paper, we almost completely solve the existence of a ‐semiframe of type for all and a ‐semiframe of type for all and .

Transcriptome and hypoxia-responsive gene expression analyses reveal the physiological reaction to acute hypoxia and reoxygenation in Epinephelus coioides

Dissolved oxygen (DO) is crucial for fish farming, and when fish experience hypoxic stress, negative effects such as the disruption of normal physiological activities, a decline in aerobic swimming ability, and feeding restriction will occur. In this study, healthy Epinephelus coioides individuals were subjected to hypoxic (DO = 0.6 ± 0.1 mg/L) and reoxygenation treatments (DO = 6.0 ± 0.1 mg/L), with a normoxic group (DO = 6.0 ± 0.1 mg/L) set as the control. Transcriptome sequencing (RNA-seq) was performed on the brains of E. coioides in hypoxia-sensitive (EBW), hypoxia-tolerant (EBS), and normoxic control (CB) groups. In total, 1174 differentially expressed genes (DEGs) were screened from the three groups. KEGG analysis revealed several pathways, including the HIF-1 signaling pathway, and immune-related pathways such as MAPK signaling, microRNAs (miRNAs), and oxidative phosphorylation pathways enriched in the EBS group, and cAMP signaling pathway enriched in the EBW group. Moreover, a variety of significant hypoxia-responsive DEGs involved in energy metabolism and immune reactions were identified in the EBS and EBW groups. qRTPCR analysis showed that the key DEGs HIF-1α, LDH-A, PPARα, PNP, RAB13, DDIT4, TNF-1, and ALDOA were significantly upregulated in the brain tissues of E. coioides under acute hypoxic stress and that their expression returned to normoxic levels after reoxygenation, indicating that they provided energy to the organism and regulated severe damage and lesions appearing in the brains of E. coioides during hypoxic stress to prolong the survival time of the organism. Altogether, these results suggest that hypoxia disrupts the expression patterns of multiple genes in E. coioides and that these genes may participate in resistance and adaptation to hypoxia in the organisms by regulating apoptosis, proliferation, differentiation, and energy metabolism.

Comparing vNOTES Hysterectomy with Laparoscopic Hysterectomy for Large Uteri

Our study aimed to compare conventional laparoscopic hysterectomies (LHs) with vaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomies performed for patients with large uteri (weight >280 g) at our institution, which underwent a change in practice from conventional LH to vNOTES for large uteri. Retrospective cohort. French tertiary university hospital. Two cohorts: the last 54 patients who underwent vNOTES hysterectomy and the last 52 patients who underwent conventional LH for large uteri. Baseline characteristics and surgical outcomes were assessed, including uterine weight, mode of delivery for previous pregnancies, history of abdominal surgery, indication for hysterectomy, associated procedures, operative time (OT), complications, volume of intraoperative bleeding, and length of postoperative hospital stay. Both groups were comparable, with a mean uterine weight of 586.4 ± 289.2 g in the laparoscopy group compared with 686.7 ± 374.6 g in the vNOTES group. There was a significant decrease in the OT in the vNOTES group with a median of 99 minutes (66.5-138.5 minutes) compared with 171 minutes (131-208 minutes) in the laparoscopy group, p <.001. The length of hospital stay was also decreased in the vNOTES group with a median of 0.5 nights compared with 2 nights in the laparoscopy group, p <.001. More patients were managed in an ambulatory setting in the vNOTES group (50% vs 3.7%, p <.001). Our study did not find any significant difference in terms of bleeding or the number of conversions to another surgical approach. The frequency of intraoperative and postoperative complications was very low. Compared with the laparoscopic approach, vNOTES hysterectomy for large uteri (>280 g) is associated with decreased OT, a shorter hospital stay, and increased performance in the ambulatory setting.

A Role of β2-Adrenoreceptor Agonists Related to the Development of Parkinson's Disease.

Several studies have suggested the potential protective role of β2-adrenoreceptor agonist (β2AR-agonist) on the development of Parkinson's disease (PD). However, those could not reflect a different epidemiologic background in eastern countries. We explored β2AR-agonist's effect on PD development by controlling for smoking. We used the Korean national sample cohort data (from 2002 to 2013) containing 1,025,340 participants (2.2% of the whole population). The subjects over 60 years were included. PD was defined based on the ICD-10 code, which should be diagnosed by neurologists. Atypical Parkinsonisms or ataxic disorders were excluded. We made Set 1 (from 2003 to 2007) and Set 2 (from 2003 to 2008) based on the exposure period for the sensitivity analysis. We observed whether PD had developed during the follow-up periods in each subset. The PD (Set 1, n = 742; Set 2, n = 699) and non-PD group (Set 1, n = 57,645; Set 2, n = 66,586) were collected. Old age, Medicaid, and asthma were risk factors, whereas smoking was a significant protective factor for PD development. The proportion of β2AR-agonist use was significantly higher in the PD group than in the non-PD group (Set 1, 3.6% vs. 2.4%; Set 2, 4.1% vs. 2.6%). β2AR-agonist use still was a risk factor in developing PD from the multiple logistic regression analysis. β2-AR-agonist looked like a risk factor rather than a protective factor for PD development. Well-controlled studies reflecting various epidemiologic backgrounds are required to confirm the role of β2AR-agonist.

O-110 Mild stimulation is the future in ART

Abstract The World Health Organisation has called for a simple, safe, and effective IVF treatment which could be both affordable and widely accessible. Unfortunately, IVF practice in developed countries seems to be trending in the opposite direction, making ovarian stimulation more intense, complex, expensive, and globally inaccessible, under the pretext of maximising the cumulative live birth rate (LBR) or by offering a ‘package’ of a ‘complete family’ from a single attempt of IVF. In reality, data from randomised controlled trials (RCTs) has found no difference in fresh cycle as well as cumulative LBRs whether a mild or high stimulation dose is administered. This is because, higher oocyte yield with high ovarian stimulation does not translate into better-quality embryos and this has been demonstrated in systematic reviews and meta-analyses. There appears to be confusion between stimulation ‘dose’ and ‘response’. Young women with good ovarian reserve are more likely to have a high response to stimulation despite being treated with a dose that falls within the definition of ‘mild stimulation’, whereas aggressive stimulation fails to improve the response in poor responders. A rising cumulative LBR with increasing number of oocytes is attributable to these good responders, but this is disconnected with the intensity of ovarian stimulation. The euploid embryo yield similarly is related to the number of oocytes and cumulative LBR which are influenced by the woman’s age and ovarian reserve but not the stimulation dose. Both the numbers of aneuploid and euploid embryos rise with increasing oocyte yield, keeping the proportion unchanged. Advocates of ‘one and done’ approach have shown that only 1 in 5 women can produce the requisite number of oocytes to have more than 1 child. This means, the remaining 80% patients would be subjected to intense stimulation, incurring risks of overstimulation, treatment burden and cost without achieving the goal of ‘completing’ their family. Psychological analysis from a RCT reported a higher incidence of post-treatment depression after Conventional compared to Mild IVF. Even in the era of agonist trigger and ‘freeze all embryos’, OHSS has not been totally eliminated- the World Registry reported around 40 cases of severe OHSS in 10 000 cycles. Clinical complications such as haemorrhage and infection associated with overstimulation could be magnified in low-resource settings with lack of facilities and expertise. Livebirth rates albeit of key importance cannot be the only index of success. Our commitment should be to make IVF accessible globally by adopting effective stimulation protocols that reduce treatment burden and cost for the patient and improve health outcomes for mother and baby. Only mild stimulation IVF can fulfil this global vision and need as an increasing body of evidence has confirmed that mild stimulation is as successful as conventional stimulation, while being safer and less expensive. Individualised mild stimulation protocols are the smartest way forward in a global setting for all patient groups. It is time to reflect on what is best for our patients and society in the long-term.

Constructing knots with specified geometric limits

It is known that any tame hyperbolic 3-manifold with infinite volume and a single end is the geometric limit of a sequence of finite volume hyperbolic knot complements. Purcell and Souto showed that if the original manifold embeds in the 3-sphere, then such knots can be taken to lie in the 3-sphere. However, their proof was nonconstructive; no examples were produced. In this paper, we give a constructive proof in the geometrically finite case. That is, given a geometrically finite, tame hyperbolic 3-manifold with one end, we build an explicit family of knots whose complements converge to it geometrically. Our knots lie in the (topological) double of the original manifold. The construction generalises the class of fully augmented links to a Kleinian groups setting.

NET-02: a randomised, non-comparative, phase II trial of nal-IRI/5-FU or docetaxel as second-line therapy in patients with progressive poorly differentiated extra-pulmonary neuroendocrine carcinoma.

The prognosis for patients with poorly-differentiated extra-pulmonary neuroendocrine carcinoma (PD-EP-NEC) is poor. A recognised first-line (1L) treatment for advanced disease is etoposide/platinum-based chemotherapy with no standard second-line (2L) treatment. Patients with histologically-confirmed PD-EP-NEC (Ki-67>20%; Grade 3) received IV liposomal irinotecan (nal-IRI) (70mg/m2 free base)/5-FU (2400mg/m2)/folinic acid, Q14 days (ARM A), or IV docetaxel (75mg/m2), Q21 days (ARM B), as 2L therapy. Primary endpoint was 6-month progression-free survival (PFS) rate (80% power to demonstrate one-sided 95% lower confidence interval excluded 15% (target level of efficacy: 30%)). Secondary endpoints: objective response rate (ORR), median PFS, overall survival (OS), toxicity and patient-reported quality-of-life (QoL) (ClinicalTrials.gov: NCT03837977). Of 58 patients (29 each arm); 57% male, 90% ECOG PS 0/1, 10% PS 2, 89.7% Ki-67≥55%, primary site: 70.7%-gastrointestinal, 18.9%-other, 10.3%-unknown, 91.4%/6.9%/1.7% were resistant/sensitive/intolerant to 1L platinum-based treatment, respectively. The primary end-point of 6-month PFS rate was met by ARM A: 29.6% (lower 95% Confidence-Limit (CL) 15.7), but not by ARM B: 13.8% (lower 95%CL:4.9). ORR, median PFS and OS were 11.1% (95%CI:2.4-29.2) and 10.3% (95%CI:2.2-27.4%); 3 months (95%CI:2-6) and 2 months (95%CI:2-2); and 6 months (95%CI:3-10) and 6 months (95%CI:3-9) in ARMS A and B, respectively. Adverse events≥grade 3 occurred in 51.7% and 55.2% (1 and 6 discontinuations due to toxicity in ARMS A and B), respectively. QoL was maintained in ARM A, but not ARM B. nal-IRI/5-FU/folinic acid, but not docetaxel, met the primary endpoint, with manageable toxicity and maintained QoL, with no difference in OS. ORR and median PFS were similar in both arms. This study provides prospective efficacy, toxicity and QoL data in the 2L setting in a disease group of unmet need, and represents some of the strongest evidence available to recommend systemic treatment to these patients. Servier.

Asia-Pacific Leukemia Consortium: An innovative and collaborative initiative to improve care of leukemia and related diseases in the Asia-Pacific region.

The burden of leukemia and related diseases is rapidly growing in Asia. Currently, there is a paucity of regional collaborative groups/initiatives that focus exclusively on the management of leukemia in the Asia-Pacific (APAC) region. The Asia-Pacific Leukemia Consortium (APLC) was established on the 8 September 2021 to understand the status quo, unmet needs, and ways to improve the management of leukemia and related diseases in the APAC region. The APLC working group set up a group of experts from various countries (Singapore, Malaysia, Thailand, Hong Kong, Japan, South Korea, Taiwan, China, and Australia) to discuss on the status of: (i) clinical trials; (ii) disease registry database; (iii) genetic and tissue repository; (iv) patient advocacy and care; and (v) disease prevention and education in the APAC region. Low levels of awareness about leukemia amongst the public, lack of financial support, and limited access to newly approved therapies were identified as barriers to the implementation of effective leukemia management in low- or mid-income Asian countries. Patients often enroll in clinical trials to gain access to novel/approved therapies. The APLC group aims to address the growing threat of leukemia through a collaborative approach to advance disease prevention, research, clinical trials, and education.

Surviving the Second World War: resilience strategies within the French facially disfigured veterans’ association

ABSTRACT Veterans’ organisations boomed in the wake of the First World War, many of their members joined together by a shared experience but also the desire to make this conflict the wars to end all war. Yet only two decades later, a new conflict started. This article examines how one of the best-known and wealthiest organisations, the Union des Blessés de la Face—Association des Gueules Cassées [Union of the Facially Wounded—‘Broken Mugs” Association] responded to the outbreak of another conflict. Drawing upon press articles and the bulletins and newsletters published by the Union, this article investigates the impact of the war on a group set up by and for mutilated WWI veterans. Having defended a pacifist agenda in the interwar years, with Pétain as its honorary president and faced with the merger of most veterans’ associations into a single Légion française des combattants in 1940, how did the Union adapt to try and survive the new war, the division of France, and the Libération? This study furthers our understanding of the history of veterans’ organisations and the history of the Second World War, and it provides insights into organisational resilience within the charitable sector in a historical perspective.

Counting independent sets in amenable groups

AbstractGiven a locally finite graph $\Gamma $ , an amenable subgroup G of graph automorphisms acting freely and almost transitively on its vertices, and a G-invariant activity function $\unicode{x3bb} $ , consider the free energy $f_G(\Gamma ,\unicode{x3bb} )$ of the hardcore model defined on the set of independent sets in $\Gamma $ weighted by $\unicode{x3bb} $ . Under the assumption that G is finitely generated and its word problem can be solved in exponential time, we define suitable ensembles of hardcore models and prove the following: if $\|\unicode{x3bb} \|_\infty &lt; \unicode{x3bb} _c(\Delta )$ , there exists a randomized $\epsilon $ -additive approximation scheme for $f_G(\Gamma ,\unicode{x3bb} )$ that runs in time $\mathrm {poly}((1+\epsilon ^{-1})\lvert \Gamma /G \rvert )$ , where $\unicode{x3bb} _c(\Delta )$ denotes the critical activity on the $\Delta $ -regular tree. In addition, if G has a finite index linearly ordered subgroup such that its algebraic past can be decided in exponential time, we show that the algorithm can be chosen to be deterministic. However, we observe that if $\|\unicode{x3bb} \|_\infty&gt; \unicode{x3bb} _c(\Delta )$ , there is no efficient approximation scheme, unless $\mathrm {NP} = \mathrm {RP}$ . This recovers the computational phase transition for the partition function of the hardcore model on finite graphs and provides an extension to the infinite setting. As an application in symbolic dynamics, we use these results to develop efficient approximation algorithms for the topological entropy of subshifts of finite type with enough safe symbols, we obtain a representation formula of pressure in terms of random trees of self-avoiding walks, and we provide new conditions for the uniqueness of the measure of maximal entropy based on the connective constant of a particular associated graph.

Calculation of Social Benefits of Influenza Vaccination based on Statistical Data

The goal we set in our study has had no precedent either in the Hungarian or in the international literature: our intention was to quantify the effectiveness of influenza vaccination based on facts, and to define the number of non-occurred diseases as a result of vaccination. We evaluated data from the influenza season of 2018/2019 in our study. We analyzed the available data on population, vaccination and the number of diseases, and drew objective conclusions therefrom. It was a problem that the basic data appeared in different data sets for different age groups, so we had to find a consensus between them, and establish comparable age groups. Ultimately, we defined three distinct age groups: the age group of minors (0-18 years), the economically active (19-59 years) and the age group of over 60 years. These three age groups became well distinguishable by population, vaccination, and morbidity. We described the influenza disease in general, the characteristics and variability of the influenza virus. We defined the typically affected age group, the number of patients to be treated, the trends for the past 5-10 years. The presented facts, numbers, the results of the calculations, and the conclusions drawn clearly show – excluding subjectivity – the preventive effect and effectiveness of vaccination, which was quantified for the first time in Hungarian literature.

Fourth AIAA High-Lift Prediction Workshop: Fixed-Grid Reynolds-Averaged Navier–Stokes Summary

The current state-of-the-practice technology for high-lift aerodynamic simulations is to solve the Reynolds-averaged Navier–Stokes (RANS) equations on a fixed grid or a refinement sequence of fixed grids. The Fixed-Grid Reynolds-Averaged Navier–Stokes Technology Focus Group set out to determine meshing requirements and best practices, whether RANS can accurately predict the change in aerodynamic performance with changes in flap deflection, whether RANS modeling can produce accurate results near CLmax, and the effects of underconvergence and solution strategy on computed results. Eighteen groups of participants submitted over 100 datasets. Challenges with grid convergence and iterative convergence made it impossible to definitively answer all the questions we had posed. Despite this, we can conclude that meshes with at least half a billion cells (more than one billion degrees of freedom) are required for grid convergence away from stall; that RANS simulations cannot currently be reliably used to predict aerodynamic coefficients near stall, nor changes in coefficients with changes in flap angle; that iterative underconvergence remains a significant source of uncertainty in outputs; and that solution initialization can have an important effect on solution behavior, including flow separation patterns.

Muscle Hypertrophy Responses to Changes in Training Volume: A Retrospective Analysis.

This study assessed associations between changes in the weekly number of sets performed and the percentage change in muscle thickness of the biceps (MTBB) and triceps (MTTB) brachii muscles. Through a retrospective analysis, sixty-eight resistance-trained subjects that participated in previous studies had their previous training volumes analyzed and compared to the volume imposed during each individual study. The relationship between variables was determined through Spearman correlation and a k-cluster analysis was performed to subdivide the participants into three groups and classified as:<0%; 0-50%, and >50% increase in the number of sets for both muscle groups. Moderate and weak correlations were observed between the alterations in training volume and changes in MTBB (rs=0.44, p=0.001) and MTTB (rs=0.35, p=0.002), respectively. A significant difference was noted between<0% to >50% for MTBB and MTTB (p=0.017; p=0.042, respectively), while no significant difference was observed between<0% to 0-50% and 0-50% to >50% (both p >0.05) for both muscle groups. In conclusion, muscle hypertrophy of the upper limbs is only weakly to moderately associated with changes in training volume of trained subjects.

The Portuguese industrial pelagic longline fishery in the Northeast Atlantic: Catch composition, spatio-temporal dynamics of fishing effort, and target species catch rates

The multispecific and highly dynamic nature of pelagic longline fisheries demands a holistic view that will likely benefit the development of effective management strategies. This study aims to provide an integrated perspective of the Portuguese longline fishery targeting swordfish Xiphias gladius and blue shark Prionace glauca in the Northeast Atlantic, regarding fishing dynamics, target species catches and associated bycatch. Data from 896 observed fishing sets (887,641 hooks) collected between 2015 and 2020 were used in a cluster analysis to group sets according to the target species. These sets were investigated for spatio-temporal patterns, and the relationship between target species catches and environmental and operational characteristics were examined using generalized additive mixed models (GAMM). A total of 46,306 individuals from 54 species (30 fish, 11 sharks, 2 manta rays, 6 cetaceans, 2 sea turtles and 2 seabirds) were recorded. Swordfish and blue shark comprised over 88.3% of the total catch in numbers (33.6% and 54.7%, respectively). Overall, most of the fishing effort occurred west off mainland Portugal, congregated during autumn when vessels targeted mostly swordfish, and dispersed over the region during spring and summer, when vessels targeted mostly blue shark. The bycatch of sea turtles and a relatively higher diversity of bony fish species, yet low catch in terms of abundance, appeared more associated with sets identified as targeting swordfish. Recorded catch of tunas Thunnus spp. and pelagic sharks, such as the shortfin mako Isurus oxyrinchus and the porbeagle Lamna nasus, were more associated with blue shark sets. Bigeye thresher Alopias superciliosus, thresher Alopias vulpinus, pelagic stingray Pteroplatytrygon violacea and lancetfish Alepisauros ferox were found equally associated with both targeted species. Management strategies for the region are discussed in light of these new findings.

Bianca Torre Is Afraid of Everything by Justine Pucella Winans

Reviewed by: Bianca Torre Is Afraid of Everything by Justine Pucella Winans Natalie Berglind Winans, Justine Pucella Bianca Torre Is Afraid of Everything. Clarion, 2023 [384p] Trade ed. ISBN 9780358721642 $19.99 E-book ed. ISBN 9780358721659 $10.99 Reviewed from digital galleys Ad Gr. 7-10 Sixteen-year-old lesbian Bianca Torre has a laundry list of the many things they fear, from public speaking to sheep to beautiful people. Their closest friend, Anderson, is a fellow anime aficionado, but otherwise, they interact with the world through their telescope, allegedly birding (but usually people watching). When they spy a shut-in neighbor get murdered in his window, they understandably can't keep quiet—but someone wants them to, as evidenced by bloody threats left across their door. Now, they feel compelled to investigate a murder that the police ruled as a suicide, but along with trying out new pronouns themself and acting on their crush on a fellow birder, they've got their hands full. While Bianca's narration is sardonic and witty, they don't stand out from other YA protagonists with similar personalities, and the story is bogged down by frequent recitations of their long list of fears and anime references that don't add to the text. The mystery itself is interesting, but the author doesn't lean into the ridiculousness of a money-swindling birding group set on murder enough to truly be campy, and the book is never serious enough to create tension. The true golden moments come from Bianca's down-to-earth experiences—their journey through their acceptance of the nonbinary label, acknowledging Anderson as their best friend through their shared hobby, and navigating their crush are much more compelling elements than the thriller ones. Copyright © 2023 The Board of Trustees of the University of Illinois

An International Society for Cell & Gene Therapy working group short report on the future of expanded access to unapproved cell and gene therapies

Patient interest in non-trial access pathways to investigational cell-and gene-based interventions, such as expanded access in the USA, is increasing, while the regulatory and business environments for non-trial access in the cell and gene therapy field are shifting. Against this background, in 2022 the International Society for Cell & Gene Therapy (ISCT) established a Working Group on Expanded Access to identify practical, ethical, and regulatory issues emerging from the use (and possible misuse) of the expanded access pathway in the cell and gene therapy field. In this Short Report, the Working Group sets the stage for its future activities by analyzing the history of expanded access and identifying three examples of questions that we anticipate arising as uses of expanded access for investigational cell and gene-based interventions increase and evolve.

Toward Enhanced Clinical Decision Support for Patients Undergoing a Hip or Knee Replacement: Focus Group and Interview Study With Surgeons

The current assessment of recovery after total hip or knee replacement is largely based on the measurement of health outcomes through self-report and clinical observations at follow-up appointments in clinical settings. Home activity-based monitoring may improve assessment of recovery by enabling the collection of more holistic information on a continuous basis. This study aimed to introduce orthopedic surgeons to time-series analyses of patient activity data generated from a platform of sensors deployed in the homes of patients who have undergone primary total hip or knee replacement and understand the potential role of these data in postoperative clinical decision-making. Orthopedic surgeons and registrars were recruited through a combination of convenience and snowball sampling. Inclusion criteria were a minimum required experience in total joint replacement surgery specific to the hip or knee or familiarity with postoperative recovery assessment. Exclusion criteria included a lack of specific experience in the field. Of the 9 approached participants, 6 (67%) orthopedic surgeons and 3 (33%) registrars took part in either 1 of 3 focus groups or 1 of 2 interviews. Data were collected using an action-based approach in which stimulus materials (mock data visualizations) provided imaginative and creative interactions with the data. The data were analyzed using a thematic analysis approach. Each data visualization was presented sequentially followed by a discussion of key illustrative commentary from participants, ending with a summary of key themes emerging across the focus group and interview data set. The limitations of the evidence are as follows. The data presented are from 1 English hospital. However, all data reflect the views of surgeons following standard national approaches and training. Although convenience sampling was used, participants' background, skills, and experience were considered heterogeneous. Passively collected home monitoring data offered a real opportunity to more objectively characterize patients' recovery from surgery. However, orthopedic surgeons highlighted the considerable difficulty in navigating large amounts of complex data within short medical consultations with patients. Orthopedic surgeons thought that a proposed dashboard presenting information and decision support alerts would fit best with existing clinical workflows. From this, the following guidelines for system design were developed: minimize the risk of misinterpreting data, express a level of confidence in the data, support clinicians in developing relevant skills as time-series data are often unfamiliar, and consider the impact of patient engagement with data in the future. RR2-10.1136/bmjopen-2018-021862.

Novel, Validated 5-Point Photonumeric Scales for Assessment of the Perioral Region.

The use of validated scales is still considered the gold standard in evaluating the severity of an aesthetic facial condition. The objective of this investigation was to create and validate 5-point photo numeric scales which assess perioral lines and marionette lines. A medical team created two different novel 5-point photonumeric scale for the assessment of perioral lines and marionette lines. Eleven international raters were involved in the digital validation, while 4 raters performed a live validation. For the Croma Static Perioral Lines-Assessment Scale digital inter-rater ICCs were 0.88 [95% CI: 0.85-0.91] in the first rating and 0.87 [0.83-0.90] in the second rating. The digital intra-rater ICCs were 0.90 [95% CI: 0.87-0.92]. In the live rating, the inter-rater ICCs were 0.89 [95% CI: 0.85-0.93] in the first rating and 0.91 [95% CI: 0.87-0.93] in the second rating with an intra-rater ICC of 0.91 [95% CI: 0.88-0.95]. For the Croma Marionette Lines-Assessment scale the digital rating inter-rater ICCs were 0.85 [95% CI: 0.81-0.89] in the first rating and 0.87 [95% CI: 0.84-0.90] in the second rating with an intra-rater ICC of 0.89 [95% CI: 0.88-0.91]. In the live rating, the inter-rater ICCs were 0.73 [95% CI: 0.54-0.83] in the first rating and 0.79 [95% CI: 0.65-0.87] in the second rating with an intra-rater ICC of 0.88 [95% CI: 0.83-0.94]. It is to be concluded that the Croma Static Perioral Lines-Assessment Scale and the Croma Marionette Lines-Assessment Scale have exceptional inter- and intra-rater agreements to be justifiably used in the clinical and study setting for all ethnic groups.