LifeSet is one of the nation’s first and largest evidence-informed programs helping youth who age out of foster care, serving more than 20,000 youth since 1999. Youth benefit from intensive practices such as weekly face-to-face meetings with specialists, regular communication, crisis intervention, relationship skills, and assistance with safe housing, education, and employment. In this presentation, child and adolescent psychiatrists will hear the findings from a randomized controlled trial of the program and direct feedback from a youth presenter. Youth eligible for the trial were ages 18 to 22 years and without needs for high-acuity mental health or substance abuse services, in state custody at least 1 year after age 14 or at least 1 day after age 17 and interested in the program. Youth who are unable to reach independent-living goals due to intellectual disabilities or those engaged in serious gang activity posing a staff safety risk were excluded. Those who consented to the study were randomized to 60% receiving LifeSet and 40% receiving usual community services. Baseline data were collected, a follow-up survey was conducted at 1 year, and selected outcomes were gathered at 2 years. The presenter will share these findings, and a youth presenter will put them in context with their personal program experience. At 1 year after study admission, LifeSet youth were significantly less likely to have experienced housing instability and economic hardship or involvement in a domestic violence relationship, and they reported higher earnings and fewer mental health issues. The impact at 2 years postadmission was consistent, with LifeSet youth showing positive outcomes in employment and earnings. No impact was found at either time point in the areas of educational attainment, criminal justice involvement, or social support. There were no negative findings from the study. LifeSet has rigorous evidence of having a positive impact in multiple domains for youth served by the program. Much work has been done since the study results were released to understand the findings and improve aspects of the program, especially related to criminal justice involvement and educational attainment. A second randomized trial of LifeSet is set to begin in mid-2021.