Introduction. Differences in understanding the main sources of effect and benefits that accompany the interaction of SME with each other and with large industrial enterprises indicate the ambiguity of ways to measure and evaluate such interaction and its scope, which in the face of changing consumer preferences requires further study. Methods. The following special methods of scientific cognition were used in the research process: historical-logical method (in the study of the evolution of changes in the value of SMEs under the influence of changes in consumer preferences); method of systematization, classification and theoretical generalization (use of the potential of interaction between SMEs and large enterprises); method of institutional analysis (in the study of the transformation of the SME management process); method of system analysis (in the study of the classification of interactions of small and medium enterprises); method of logical analysis and synthesis (in the construction of forms of interaction between SMEs and large enterprises); method of graphical analysis (in the development of configurations of varieties of the structure of the satellite form of interaction of industrial SMEs and large enterprises). Results. It is proved that one of the directions of development of modern industrial SME in Ukraine is the use of various forms and methods of partnership: from concluding long-term bilateral supply agreements to creating new SME of design and process type to solve new problems. The most promising partners of manufacturing SME in Ukraine are large industrial enterprises, whose growth opportunities due to limited resources, high competition from foreign manufacturers, almost complete lack of state support are almost exhausted. Production SME are characterized by dipole and network interaction with large industrial enterprises - cooperation of their activities, which provides for mutually beneficial counterparty relations: a large enterprise on the basis of contractual relations orders from production SME certain products or services of production nature with definition of their specification or semi-finished products. The function of production SME is to perform a separate operation of the production process or a certain type of production service. Discussion. To study the possibilities of cooperation of industrial SMEs with large industrial enterprises, it is advisable to determine the regional specifics of industrial SMEs, using the method of rating the investment competitiveness of regions by number of manufacturing SMEs, number of employees, sales and financial results. This would make it possible to identify the districts of the region whose small production enterprises need the most support. Keywords: managerial, marketing and financial approaches, evaluation, socio-ecological-economic effect, interaction of enterprises, change of consumer preferences.
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