You have accessJournal of UrologyProstate Cancer: Markers I1 Apr 20122111 SERUM SEX STEROIDS DEPICT A NON LINEAR U-SHAPED ASSOCIATION WITH HIGH RISK PROSTATE CANCER AT RADICAL PROSTATECTOMY - IMPLICATIONS FOR INDIVIDUALIZED HORMONAL THERAPY Andrea Salonia, Firas Abdollah, Umberto Capitanio, Alberto Briganti, Nazareno Suardi, Andrea Gallina, Matteo Ferrari, Giulia Castagna, Maria Chiara Clementi, Patrizio Rigatti, and Francesco Montorsi Andrea SaloniaAndrea Salonia Milan, Italy More articles by this author , Firas AbdollahFiras Abdollah Milan, Italy More articles by this author , Umberto CapitanioUmberto Capitanio Milan, Italy More articles by this author , Alberto BrigantiAlberto Briganti Milan, Italy More articles by this author , Nazareno SuardiNazareno Suardi Milan, Italy More articles by this author , Andrea GallinaAndrea Gallina Milan, Italy More articles by this author , Matteo FerrariMatteo Ferrari Milan, Italy More articles by this author , Giulia CastagnaGiulia Castagna Milan, Italy More articles by this author , Maria Chiara ClementiMaria Chiara Clementi Milan, Italy More articles by this author , Patrizio RigattiPatrizio Rigatti Milan, Italy More articles by this author , and Francesco MontorsiFrancesco Montorsi Milan, Italy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2279AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To assess the association between preoperative serum total testosterone (tT), 17β estradiol (E2), sex hormone–binding globulin (SHBG), and tT/E2 ratio values with high risk prostate cancer (PCa) [as defined by the National Comprehensive Cancer Network (NCCN) practice guidelines™] at radical prostatectomy (RP). METHODS A cohort of 724 candidates to RP at a single Institution was used. Serum E2, tT, and SHBG were dosed the day before surgery (7-11 A.M.) in all cases. Restricted cubic spline functions with two-knots tested the association between predictors [ie, Model 1 including age, BMI, serum tT, E2, and SHBG levels; Model 2 with tT/E2 values instead of tT and E2 levels] and high risk PCa. RESULTS Low, intermediate or high risk PCa was found in 251 (34.7%), 318 (43.9%) and 155 (21.4%) patients, respectively. Patients in the high risk class showed the lowest tT, E2 and tT/E2 ratio values (all p ≤ 0.02). Conversely, patients did not differ in terms of age, BMI, and SHBG levels across the classes of risk. Hypogonadal patients were significantly more frequent over classes of increased risk (p = <0.001). At univariate analysis, only age, tT, E2, and tT/E2 ratio values were significantly associated with high risk PCa (all p≤0.006). At multivariate analyses considering Model 1 variables, age (p=0.03), serum tT (all p<0.001), and E2 (all p≤0.01) were associated with high risk PCa; only tT/E2 ratios achieved independent predictor status for high risk class PCa (all p<0.001) when considering Model 2. Both the lowest and the highest tT, E2, and tT/E2 values depicted a non-linear U-shaped significant association with high risk class PCa. CONCLUSIONS These data showed that preoperative serum sex steroids are independent predictor of high risk PCa, depicting a non-linear U-shaped association. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e852 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Andrea Salonia Milan, Italy More articles by this author Firas Abdollah Milan, Italy More articles by this author Umberto Capitanio Milan, Italy More articles by this author Alberto Briganti Milan, Italy More articles by this author Nazareno Suardi Milan, Italy More articles by this author Andrea Gallina Milan, Italy More articles by this author Matteo Ferrari Milan, Italy More articles by this author Giulia Castagna Milan, Italy More articles by this author Maria Chiara Clementi Milan, Italy More articles by this author Patrizio Rigatti Milan, Italy More articles by this author Francesco Montorsi Milan, Italy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...