Objective To explore the application value of Internet + model in esophageal cancer patients in chemotherapy. Methods A total of 90 patients with esophageal cancer treated in the First Affiliated Hospital of Zhengzhou University from January 2017 to January 2019 were selected by convenient sampling method, and all received chemotherapy. They were divided into observation group (n=45) and control group (n=45) according to the random number table method. The control group adopts routine nursing management, and the observation group adopts the Internet + management model. Blood samples were taken before the nursing intervention and 6 months after the intervention to measure the nutritional indicators of the two groups, including serum prealbumin (PA) , albumin (ALB) , and transferrin (TRF) levels. The Connor-Davidson Psychological Resilience Scale was used to evaluate the psychological resilience of the two groups of patients. Results The levels of serum PA, ALB, and TRF in the two groups after intervention were higher than those before intervention, and the observation group were higher than the control group, the differences were statistically significant (P<0.05) . After intervention, the mental impact, acceptance changes, tolerance of negative emotions, ability, control scores, and total psychological elasticity scores of the two groups were higher than before the intervention, and the observation group were higher than the control group, and the differences were statistically significant (P<0.05) . Conclusions Compared with traditional nursing management, the Internet + management model can further improve the nutritional level and mood of esophageal cancer patients in chemotherapy, and the overall application effect is good. Key words: Esophageal neoplasm; Internet +; Chemotherapy; Nutritional status; Psychological resilience