Serum Levels Of SOD Research Articles

The effect of head hypothermia on the large-acreage cerebral insarction(LCI) and hyperthermia patient's serum CORT,SOD and LPO level

目的 探讨大面积脑梗死(LCI)高热患者血清皮质醇(CORT)、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)的含量变化,观察头部低温降温对三者的影响.方法采用放射免疫法、羟胺氧化法、丙二醛法测定49例(A组)LCI应用头部低温降温与43例(B组)应用温水擦浴、冰盐水灌肠降温者入院第2天及高热后第2天、第3天、第4天血清中CORT、LPO、SOD含量,并与30例健康人(C组)作对照.同时对两组生存者生活质量进行比较.结果 A、B两组入院第2天较C组CORT、LPO明显升高和SOD降低(P＜0.01).A、B两组高热第2天较入院第2天CORT、LPO均明显升高和SOD显著降低(P＜0.05,P＜0.01).A组高热第4天较入院第2天和高热第2天CORT、LPO显著降低(P＜0.05,P＜0.01),SOD升高(P＜0.01).B组高热第4天CORT、LPO仍高于和SOD低于入院第2天(P＜0.05).结论头部低温可有效使LCI高热患者CORT、LPO降低和SOD升高,提高预后生活质量。

Serum levels of manganese superoxide dismutase in patients with localized scleroderma.

The objective was to determine the serum levels of manganese superoxide dismutase (Mn SOD) in patients with localized scleroderma and investigate their clinical significance in this disease. Serum samples from 15 patients with localized scleroderma and 20 healthy volunteers were examined by a specific enzyme-linked immunosorbent assay. Serum levels of Mn SOD were significantly higher in patients with generalized morphea than those in healthy individuals. And the patients with elevated serum Mn SOD levels had significantly larger number of sclerotic lesions and significantly higher serum levels of soluble interleukin-2 receptor than those without it. These results suggested that the serum levels of this enzyme may be a serological marker for the disease activity and the extent of skin involvement in this disease.

Elevated serum levels of manganese superoxide dismutase in polymyositis and dermatomyositis

We studied serum concentrations of manganese superoxide dismutase (Mn SOD) and copper-zinc superoxide dismutase (Cu/Zn SOD) in 22 patients with polymyositis and dermatomyositis (PM/DM), 87 patients with four types of muscular dystrophy, 20 patients with amyotrophic lateral sclerosis, and 15 patients with collagen vascular diseases (CVD). Serum levels of Mn SOD were increased only in the patients with PM/DM and CVD, and the elevation was more prominent in those with PM/DM. Levels of Cu/Zn SOD were slightly elevated in some patients with PM/DM and Duchenne muscular dystrophy. In patients with PM/DM, the change in Mn SOD levels corresponded to disease activity as closely as or more closely than those of creatine kinase. The results indicate that serum Mn SOD may be a useful clinical marker for PM/DM.