In the current study thirty of male mice weighting (25-30 g) aged (15-17)weeks at the animal house faculty of science / university of Kufa during the period from January 2017 to September 2017. This study included some histological criteria to evaluate the protective role of silver nanoparticles (5 and 10 mg/kg) against asthma that induced by ovalbumin. The animals experimental are divided into three groups(10 animals) for duration of one and two months. The result sowed significant increase(p<0.05) in the serum level of periostin and Galectin -3 and Interleukin -33 in asthma group as compared with control group. The histological study of trachea tissue was sluphing, necrosis and degeneration around the epithelium of bronchioles also, there were congestion and inflammatory cells around bronchioles that treated with ovalbumin (asthma group). Whereas treatment the trachea tissue with silver nanoparticles did not show any histological changes in the trachea tissue except little inflammation.