Serum Pepsinogen Test Research Articles

ペプシノゲンの基礎と臨床

As the lecture of Predisent of the 50th Spring Meeting of the Japanese Electrophoresis Society, covered the own group's research field during the past about 20 years periods. Basic aspect and clinical significance of pepsinogens were reviewed. Contents of the lecture were the cellular localization of pepsinogen granules in the one cell, the activation mechanism of it, the entire human pepsinogen A and C genes, and the nucleotide sequence of all the exon and the 5'-and 3'-flanking regions. Topics of isozymes of human pepsinogen A (I), the schema of pepsinogen-producing mechanisms from mRNA, and electrophoretic pattern of pepsinogen A (I) from human gastric mucosa using agargel, were included. On the other hand, as for the clinical significance of pepsinogens, the first case report of pepsinogen producing gastric carcinoma with high pepsinogen II levels in both serum and ascites, and pepsinogen I and II immunohistochemical staining in gastric carcinoma tissues using the monoclonal antibodies, were presented. Finally, the clinical application of the serum pepsinogen levels in the research of Helicobacter pylori infection, gastric cancer development in the course of carcinogenesis from atrophic gastritis to gastric cancer in the population level, gastric cancer screening using serum pepsinogen test kits, which were commercially available now in Japan, and the significance of low serum pepsinogen levels to detect stomach cancer associated with extentive chronic gastritis, which was a precancerous condition of gastric cancer, were discussed.

Mass screening for gastric cancer with serum pepsinogen test in employers health examination

Mass screening for gastric cancer with serum pepsinogen test in employers health examination

胃直接Ｘ線検査に際し血清ペプシノゲン検査を行った１６６９例の検討

胃直接Ｘ線検査に際し血清ペプシノゲン検査を行った１６６９例の検討

Issues on putting serum pepsinogen test into practical use in mass survey programs for gastric cancer

Issues on putting serum pepsinogen test into practical use in mass survey programs for gastric cancer

血清ペプシノゲンの胃癌スクリーニング法としての評価

血清ペプシノゲンの胃癌スクリーニング法としての評価

第23回日本総合健診医学会学術大会講演抄録集 血清ペプシノーゲンによる胃癌検診の評価

第23回日本総合健診医学会学術大会講演抄録集 血清ペプシノーゲンによる胃癌検診の評価

転換期を迎えた胃の健診 血液法による胃癌ハイリスク診断

転換期を迎えた胃の健診 血液法による胃癌ハイリスク診断

血清ペプシノゲンによる胃がんハイリスク診断（胃ドック）

血清ペプシノゲンによる胃がんハイリスク診断（胃ドック）

Diabète sucré du sujet âgé

Although serum pepsinogen tests are useful for predicting the presence of atrophic gastritis, the optimal cut-off values have not been fully evaluated.To determine the optimal serum pepsinogen cut-off value for predicting atrophic gastritis.Patients scheduled for upper endoscopy at Severance Hospital, Korea, between August 2012 and October 2013, were recruited prospectively. Endoscopic biopsies for atrophic gastritis were obtained and histologically graded, based on the updated Sydney system.Ninety-five patients were enrolled in the study. The mean age was 57.7 ± 12.1 years, and 44.2% of the patients were male. Serum pepsinogen I/II ratios were lower in patients with atrophic gastritis than in those without it (antrum, 4.2 ± 1.7 vs. 5.2 ± 2.1, P = 0.040; corpus, 3.3 ± 1.9 vs. 5.4 ± 1.9, P < 0.001). Serum pepsinogen I/II ratios were significantly correlated with histologic atrophic gastritis (antrum, P = 0.030; corpus, P < 0.001). Using a cut-off value of 4.9, the sensitivity and specificity of the serum pepsinogen I/II ratio for predicting atrophic gastritis in the antrum were 68.2% and 60.3%, respectively.The optimal serum pepsinogen I/II ratio cut-off values for atrophic gastritis of the antrum and for the corpus were 4.9 and 3.5, respectively. Serum pepsinogen I/II ratios, with these cut-off values, are useful for screening patients for the presence of atrophic gastritis.