Serum Lipids In Men Research Articles

Effect of clofibrate on arginine-stimulated glucagon and insulin secretion in man

Insulin and glucagon have been reported to have opposing effects upon the mechanisms regulating serum triglyceride concentration. Glucagon in excess of insulin will lower serum lipids in man. In the present studies, we have examined the possibility that a change in glucagon and insulin regulation might contribute to the hypolipemic action of the drug clofibrate. Control insulin and glucagon secretion were evaluated in 24 normal subjects by intravenous arginine infusion, which resulted in a prompt rise in both serum immunoreactive insulin and glucagon concentration. During the maximum rise in concentration of these hormones, plasma triglyceride concentration was acutely reduced from basal levels of 104 ± 6 mg 100 ml to 75 ± 5 mg 100 ml ( p ≤ 0.001). Following 7 days of clofibrate therapy, basal plasma triglyceride concentration attained a new mean level of 78 ± 5 mg 100 ml , while basal insulin and glucagon concentrations remained unchanged. However, arginine infusion now resulted in a reduction of the insulin secretory response to 56% of the preclofibrate studies with an associated normal glucagon secretory response. Serum triglyceride concentration was further reduced during arginine infusion to 46 ± 3 mg 100 ml , demonstrating this minimum level as maximum plasma glucagon levels were attained, representing an excess of this hormone relative to the reduced insulin concentration. These observations are consistent with an effect of clofibrate on the hormonal regulation of triglyceride physiology in man. Glucose tolerance was unimpaired by clofibrate therapy in these normal subjects, in spite of an apparent reduction in glucose-stimulated insulin secretion.

Fatty acid composition of serum lipids in wives of men with myocardial infarction.

Abstract Two groups of healthy married women, aged 40–70 years, have been studied to determine the concentrations of major serum lipid fractions and their fatty acid composition. One group consisted of wives of men with recent myocardial infarction, and the other of wives of healthy men. No significant differences were observed in cholesterol, phospholipids, or triglyceride concentrations between the two groups or in the fatty acid composition of these lipid fractions. It has previously been demonstrated that the linoleic acid percentages in the serum lipids of men with myocardial infarction are lower than in healthy men. If dietary factors are responsible for the low linoleic acid percentages in men with myocardial infarction, the reason lies in individual habits rather than in the particular dietary habits of their families.

Effect of Amino Acid Diets upon Serum Lipids in Man

Effect of Amino Acid Diets upon Serum Lipids in Man

Use of Semisynthetic Fats in Determining Effects of Specific Dietary Fatty Acids on Serum Lipids in Man

Use of Semisynthetic Fats in Determining Effects of Specific Dietary Fatty Acids on Serum Lipids in Man

The effects of isocaloric exchange of dietary starch and sucrose on glucose tolerance, plasma insulin and serum lipids in man.

1. The effects of isocalorically exchanging dietary starch and sucrose on glucose tolerance, plasma insulin and serum lipids were examined in nine middle-aged subjects. A ‘sucrose’ period in which 70% of dietary carbohydrate was supplied as sucrose was alternated with a ‘sucrose free’ period in which dietary carbohydrate was supplied mainly as starch. Each period lasted 4 weeks; eleven balances were completed. 2. Changes in body weight during the balances were small and statistically insignificant. 3. Fasting blood sugar levels were significantly elevated during the ‘sucrose’ period. During 50 g glucose tolerance tests, blood sugar levels were slightly higher during the ‘sucrose’ period but this difference was not statistically significant. 4. Plasma insulin levels were similar during the dietary periods, both in the fasting state and after 50 g of glucose. 5. Mean levels of serum cholesterol, serum triglyceride and plasma NEFA showed no significant differences between the two dietary periods. 6. It is concluded that glucose tolerance, plasma insulin and serum lipids are not significantly altered by the substitution of sucrose for starch at levels of sucrose intake comparable to those in the Western diet.

Long-term effects of clofibrate (Atromid-S) on serum lipids in man.

Clofibrate was administered to 45 patients for varying periods of time up to 4 years with no evidence of chronic toxicity. Clofibrate was more effective in lowering serum triglycerides than serum cholesterol, with more than 75% of all patients with elevated triglycerides having at least a 25% reduction in triglycerides, the absolute reduction in triglycerides being directly correlated with pretreatment values. A reduction in serum cholesterol of 15% or more was obtained in 50% of all patients, those individuals with elevations of triglycerides having the greatest reduction in serum cholesterol as well as being most likely to respond.

Influence of Prolonged Carbon Monoxide Exposure and Altitude Hypoxia on Serum Lipids in Man

Influence of Prolonged Carbon Monoxide Exposure and Altitude Hypoxia on Serum Lipids in Man

Influence of Prolonged Carbon Monoxide Exposure and Altitude Hypoxia on Serum Lipids in Man

Serum lipid levels were investigated in 8 young volunteers exposed to carbon monoxide (average carboxyhaemoglobin saturation 13 per cent) and to an altitude of 3.454 m for 8 and 10 days respectively. Small, but significant increases were seen in serum cholesterol levels during carbon monoxide exposure as well as at high altitude. It is suggested that this effect of hypoxia is due to an inhibition of lipoprotein lipase.

EFFECTS OF ORAL CALCIUM UPON SERUM LIPIDS IN MAN.

EFFECTS OF ORAL CALCIUM UPON SERUM LIPIDS IN MAN.

The influence of some dietary fats on serum lipids in man.

The influence of some dietary fats on serum lipids in man.

Effect of Nibbling Versus Gorging on Serum Lipids in Man

Effect of Nibbling Versus Gorging on Serum Lipids in Man

EFFECT OF A SATURATED MEDIUM-CHAIN TRIGLYCERIDE ON SERUM-LIPIDS IN MAN

EFFECT OF A SATURATED MEDIUM-CHAIN TRIGLYCERIDE ON SERUM-LIPIDS IN MAN

Serum lipids in men with myocardial infarction.

Serum lipids in men with myocardial infarction.

Effects of long-term estrogen therapy on serum cholesterol and phospholipids in men with myocardial infarction.

Article1 November 1959EFFECTS OF LONG-TERM ESTROGEN THERAPY ON SERUM CHOLESTEROL AND PHOSPHOLIPIDS IN MEN WITH MYOCARDIAL INFARCTIONJESSIE MARMORSTON, M.D., FREDERICK J. MOORE, M.D., OSCAR MAGIDSON, M.D., OLIVER KUZMA, M.D., JACK J. LEWIS, M.D.JESSIE MARMORSTON, M.D.Search for more papers by this author, FREDERICK J. MOORE, M.D.Search for more papers by this author, OSCAR MAGIDSON, M.D.Search for more papers by this author, OLIVER KUZMA, M.D.Search for more papers by this author, JACK J. LEWIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-5-972 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has been well established1-8 that administration of estrogen to men or women with myocardial infarction tends to raise the serum phospholipids and to lower the serum cholesterol and the cholesterol/phospholipid (C/P) ratio. In a recent communication9 we noted that prolonged administration of ethinyl estradiol to postmenopausal women with myocardial infarction resulted in changes in these serum lipids, chiefly in those in whom the levels were initially abnormal. Thus estrogen therapy in effect tended to bring these serum lipids to "normal" levels.We wish to report here the effects upon cholesterol and phospholipids of long-term estrogen therapy, using clinically well...Bibliography1. Eilert ML: Effects of estrogens upon partition of serum lipids in female patients, Am. Heart J. 38: 472, 1949. Google Scholar2. StamlerPickKatz JRLN: Experiences in assessing estrogen antiatherogenesis in chick, rabbit and man, Ann. New York Acad. Sc. 64: 596-619, 1956. CrossrefMedlineGoogle Scholar3. RussEderBarr EMHADP: Influence of gonadal hormones on proteinlipid relationship in human plasma, Am. J. Med. 19: 4-24, 1955. CrossrefMedlineGoogle Scholar4. SteinerPaysonKendall AHFH: Effects of estrogenic hormones on serum lipids in patients with coronary arteriosclerosis, Circulation 11: 784-788, 1955. CrossrefMedlineGoogle Scholar5. OliverBoyd MFGS: Influence of sex hormones on circulating lipids and lipoproteins in coronary sclerosis, Circulation 13: 82-91, 1956. CrossrefMedlineGoogle Scholar6. RobinsonHiganoCohenSniffenSherer RWNWDRCJW: Effects of estrogen therapy on hormonal functions and serum lipids in men with coronary atherosclerosis, Circulation 14: 365, 1956. CrossrefMedlineGoogle Scholar7. Eilert HL: Effect of estrogens on partition of serum lipids in female patients, Metabolism 2: 137-145, 1953. MedlineGoogle Scholar8. CohenHiganoRobinson WDNRW: Serum lipid and estrogenic effects of Manvene, a new estrogen analogue, Circulation 17: 1035-1040, 1958. CrossrefMedlineGoogle Scholar9. MarmorstonMagidsonLewisMehlMooreBernstein JOJJJFJJ: Effect of small doses of estrogen on serum lipids in female patients with myocardial infarction, New England J. Med. 258: 583-586, 1958. CrossrefMedlineGoogle Scholar10. PearsonSternMcGavack SSTH: Rapid, accurate method for determination of total cholesterol in serum, Anal. Chem. 25: 813, 1953. CrossrefGoogle Scholar11. LowryRobertsLeinerWuFarr OHNRKYMAL: Quantitative histochemistry of brain; chemical methods, J. Biol. Chem. 207: 1-17, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Received for publication February 25, 1959.Read at the Regional Meeting of The American College of Physicians, Palm Springs, California, February 7-8, 1959.From the Departments of Medicine and Public Health, University of Southern California School of Medicine, the Los Angeles County Hospital and the Cedars of Lebanon Hospital.†Aided by grants from the Albert and Mary Lasker Foundation, and grants H-2198, H-2199 and H-2701 from the National Heart Institute.We are indebted to Dr. Kenneth Ericson, of Organon, Inc., for supplies of Lynoral (ethinyl estradiol), to Dr. Irwin C. Winter, of G. D. Searle and Co., for Manvene (SC 6924, 3 methoxy-16α-methyl-1,3,5(10)-estriene-16β,17β-diol), and to Dr. John J. Jewell, of the Ayerst Laboratories, for Premarin (mixed conjugated equine estrogens NNR), used in these studies.Requests for reprints should be addressed to Jessie Marmorston, M.D., 613 North Canon Drive, Beverly Hills, California. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRelationship of Estrogen Therapy for Carcinoma of the Prostate to Atherosclerotic Cardiovascular Disease: A Clinicopathologic StudyBiological Properties of Estrogen SulfatesARE GONADAL HORMONES (ESTROGENS AND ANDROGENS) OF SIGNIFICANCE IN THE DEVELOPMENT OF ISCHEMIC HEART DISEASE?The interrelationship of blood lipids and estrogensEfficacy of Drugs in Lowering Blood CholesterolGonadal Hormones and Lipid MetabolismSteroids and Lipid MetabolismPractical significance of serum triglycerides and radioactive fat toleranceTREATMENT OF DIABETIC RETINOPATHY WITH ESTROGENSORAL AND INTRAVENOUS ESTROGENS IN THE TREATMENT AND PREVENTION OF BLEEDING ASSOCIATED WITH LONG-TERM ANTICOAGULANT THERAPY 1 November 1959Volume 51, Issue 5Page: 972-982KeywordsCholesterolElectrocardiographyEstradiolEstrogensHeartHospital medicineLipidsMyocardial infarctionPhospholipidsPrevention, policy, and public health ePublished: 1 December 2008 Issue Published: 1 November 1959 PDF downloadLoading ...

THE EFFECTS OF ESTROGENS ON SERUM LIPIDS IN WOMEN

In 1949 Eilert demonstrated the lipid-shifting effects of estrogens in postmenopausal and castrated women. 1 Because of the preponderance of men suffering from coronary heart disease in middle age the relationship between the lipid effects of estrogens and coronary atherosclerosis has been studied chiefly in men. Recently several groups have clearly documented the striking effects of estrogens on the serum lipids of men with coronary heart disease when employed in adequate dosage for sufficient time. 2-6 However, since there is an increased incidence of coronary heart disease in postmenopausal women, the growth of the aging population has resulted in an increasingly important number of women suffering from this disease. The rise of serum cholesterol levels in women with advancing age has been well established, 7-9 but the reasons for this remain obscure. The physiological decrease of ovarian function as reflected by the progressive fall of urinary estrogen levels in aging

The Effects of Estrogens on Serum Lipids in Women

In 1949 Eilert demonstrated the lipid-shifting effects of estrogens in postmenopausal and castrated women. 1 Because of the preponderance of men suffering from coronary heart disease in middle age the relationship between the lipid effects of estrogens and coronary atherosclerosis has been studied chiefly in men. Recently several groups have clearly documented the striking effects of estrogens on the serum lipids of men with coronary heart disease when employed in adequate dosage for sufficient time. 2-6 However, since there is an increased incidence of coronary heart disease in postmenopausal women, the growth of the aging population has resulted in an increasingly important number of women suffering from this disease. The rise of serum cholesterol levels in women with advancing age has been well established, 7-9 but the reasons for this remain obscure. The physiological decrease of ovarian function as reflected by the progressive fall of urinary estrogen levels in aging

THE INFLUENCE OF GONADAL HORMONES ON SERUM LIPIDS AND LIPOPROTEINS: STUDIES IN NORMAL AND HYPOGONADAL SUBJECTS

Excerpt Clinicians have known for almost 200 years that the manifestations of coronary atherosclerosis are much more frequent in men than in women. Numerous autopsy studies have disclosed the disea...

Effects of estrogen therapy on hormonal functions and serum lipids in men with coronary atherosclerosis.

Middle-aged men with coronary atherosclerosis were studied before and at intervals after initiation of estrogen therapy over a 12-month period. Serum lipid studies during treatment revealed consistent increases in phospholipid and α-lipoprotein cholesterol and decreased β-/α-lipoprotein cholesterol ratios. Concomitant endocrine studies demonstrated the expected testicular depression without apparent detriment to thyroid or adrenal function.

The interrelationships of serum lipids in men and women past sixty-five years of age and their bearing on atherosclerosis.

The interrelationships of serum lipids, that is, free cholesterol, esterified cholesterol, total cholesterol, lipid phosphorus, total lipids, neutral fats and S f 10-20 molecules were determined in 91 women and 38 men past the age of 65 years. It was observed that all the serum lipids with the exception of neutral fats were statistically higher in the women. Furthermore, it was shown that the serum total cholesterol and serum S f 10-20 molecules were correlated to a significant degree in the men, 0.59 ± .15, but to an insignificant degree in the women, 0.21 ± .12. It was also shown that the levels of serum total cholesterol and S f 10-20 molecules increase with age within the age range 65 to 85 in the women but remain stationary or actually decrease in the men. The bearing of these findings on atherosclerogenesis is discussed.

Liver function studies during cortisone therapy.

Article1 September 1951LIVER FUNCTION STUDIES DURING CORTISONE THERAPYJOSEPH H. HOLMES, M.D., F.A.C.P., S. C. PERCEFULL, M.D.JOSEPH H. HOLMES, M.D., F.A.C.P.Search for more papers by this author, S. C. PERCEFULL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-35-3-608 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe study dealt with herein was undertaken to determine if any of the usual clinical liver function tests change in any way under cortisone therapy. It is well known that the adrenal cortex is concerned with protein,1, 2glucose3and fat4, 5metabolism. It has even been reported that the administration of ACTH will produce a fatty liver in the experimental animal, although this can be prevented by the administration of glucose.4Furthermore, patients with Cushing's syndrome frequently have hypercholesteremia, and patients with adrenal insufficiency tend to a low serum cholesterol.7A marked hypercholesteremia was observed in rabbits after adrenal...Bibliography1. BondyEngelFarrar PKFLB: The metabolism of amino acids and protein in the adrenalectomized-nephrectomized rat, Endocrinology 44: 476-483, 1949. CrossrefMedlineGoogle Scholar2. HartmanBrownell FAKA: The adrenal gland, 1949, Lea and Febiger, Philadelphia. Google Scholar3. YoungAbelsHomburger NFJCF: Studies on carbohydrate metabolism in patients with gastric cancer, defective hepatic glycogenesis; effects of adrenocortical extract, J. Clin. Investigation 27: 760-765, 1948. CrossrefGoogle Scholar4. Levin L: Physical stress and liver fat content of the fasted mouse, Federation Proc. 8: 218-219, 1949. Google Scholar5. LiIngleEvansPrestrudaNezamis CHDJHMMCJE: Effect of adrenocorticotrophic hormone upon liver fat and urinary phosphorus in normal forcefed rat, Proc. Soc. Exper. Biol. and Med. 70: 753-756, 1949. CrossrefMedlineGoogle Scholar6. GoldnerMorse MGM: Studies on serum esterase, J. Lab. and Clin. Med. 34: 858, 1949. MedlineGoogle Scholar7. Selye H: Textbook of endocrinology, 1947, Acta Endocrinologica, Montreal, Canada, p. 145. Google Scholar8. Hoffmeyer J: The influence of adrenal cortex on the cholesterol content in rabbit serum, Acta physiol. Scandinav. 10: 31, 1945. CrossrefGoogle Scholar9. AdlersbergSchaeferDritch DLER: Adrenal cortex and lipid metabolism: effects of cortisone and adrenocorticotropin (ACTH) on serum lipids in man, Proc. Soc. Exper. Biol. and Med. 74: 877, 1950. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Fort Logan, Colorado*Received for publication December 18, 1950.From the Medical Service, Veterans Administration Hospital, Fort Logan, Colorado, and the Department of Medicine, University of Colorado Medical Center.Sponsored by the Veterans Administration and published with approval of the Chief Medical Director. The statements and conclusions published by the authors are the result of their own studies and do not necessarily reflect the opinion or policy of the Veterans Administration.This work is part of a coördinated program for the study of Cortisone conducted by the Research Division of the Veterans Administration. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe treatment of chronic hepatitis with adrenal cortical hormonesUnusual Fatal Infectious Complications of Steroid-Treated Liver DiseaseHepatotoxic effect of cortisone in experimental animalsPhysiology of the Adrenal CortexTHE COURSE OF INFECTIOUS HEPATITIS WITH SPECIAL REFERENCE TO PROGNOSIS AND THE CHRONIC STAGEHepatomegaly with Fatty Infiltration Secondary to Cortisone Therapy: Case Report 1 September 1951Volume 35, Issue 3Page: 608-614KeywordsAdrenocorticotropic hormoneFatty liverGlucose metabolismHospital medicineHypercholesterolemiaLiverLiver function testsMedical servicesProtein metabolismRabbits Issue Published: 1 September 1951 PDF downloadLoading ...