Serum Lipid Profile In Patients Research Articles

Lipid Profile of Patients with Acute Myocardial Infarction (AMI).

Introduction Irrespective of underlying hyperlipidemia, the serum lipid profile witnesses a phasic fluctuation immediately after a major cardiovascular event. This study aims to evaluate the change in serum lipid profile in patients with acute myocardial infarction (AMI).MethodsIt was a prospective, cross-sectional study conducted in the department of cardiology, Shalamar Hospital, and Punjab Institute of Cardiology, from October until December 2018, focusing on patients admitted with ST-elevation myocardial infarction (STEMI). The patient's demographics and lipid profile (in mg/dl) within the first 24 hours and after 48 hours of the event were recorded.ResultsThe mean serum total cholesterol (TC) levels decreased from 207.5 ± 30.5 to 192.4 ± 49.3 after 48 hours (p-value <0.0001). Mean serum triglyceride (TGs) levels increased from 153.8 ± 10.2 to 183.8 ± 14.8 (p-value <0.0001). Mean serum low density lipid-cholesterol (LDL-C) decreased from 149.0 ± 41.2 to 133.4 ± 54.0 (p-value = 0.0003). Mean serum high density lipid-cholesterol (HDL-C) decreased from 46.6 ± 9.9 to 40.7 ± 11.8 (p-value <0.0001).ConclusionPhasic fluctuations in serum lipid profile are observed after acute myocardial infarction (AMI). The trend that follows include reduced TC, LDL-C, and HDL-C, and increased TGs. Periodic lipid profile must be evaluated in all patients admitted for AMI to understand the changing trend, initiate lifestyle measures to reach target lipid levels, and predict the choice of lipid-lowering therapy.

Serum lipid profile in patients with oral potentially malignant disorders

Aim: To estimate serum lipid profile in patients with oral potentially malignant disorders. Materials and Methods: Around 100 patients with oral potentially malignant disorders and 20 patients as controls were subjected to serum lipid profile after obtaining institutional ethical clearance. Estimation of lipid profile value was done for total serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TG) using Endpoint method. Results: HDL levels were significantly lower in females with oral potentially malignant disorders (P = 0.047). The mean value of total cholesterol, HDL, VLDL, and TG was lower in leukoplakia compared to lichen planus, smoker's palate, combined leukoplakia, and smoker's palate lesion and oral submucous fibrosis, i.e. 140.78, 32.444, 28.444, 141.33, respectively. The mean value of LDL was low in lichen planus compared to other groups, i.e. 73.167. Conclusion: This study concluded that the lower serum lipid levels might serve as a diagnostic indicator or marker in the early diagnosis of oral potentially malignant disorders in females.

Serum lipid profiles in patients with chronic kidney disease in a Saudi population

Serum lipid profiles in patients with chronic kidney disease in a Saudi population

Identification of High Serum Apolipoprotein A1 as a Favorable Prognostic Indicator in Patients with Multiple Myeloma.

This study is to explore the prognostic significance of serum lipid profiles in patients with multiple myeloma (MM). The study retrospectively enrolled 307 MM patients in Zhongshan Hospital, Shanghai, China, from 2007 to 2016. We evaluated the prognostic significance of the pre-diagnostic serum lipid profile [cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), Apolipoprotein A1 (Apo A1) and Apolipoprotein B (Apo B)]. Prognostic factors identified through univariate and multivariate analysis were used to construct a new model based on Lasso Cox regression. Results indicated that lipid levels showed significant difference between ISS stages: Apo A1, Apo B, Cholesterol and LDL levels were lower in late ISS stage. However, only Apo A1 showed statistically significance in overall survival (OS), progression free survival (PFS) and cause specific survival (CSS) (P=0.038, P=0.028, P=0.011) in univariate Cox regression. Patients with higher Apo A1 displayed longer OS (median OS, 67 months vs. 30 months; P<0.001). Also, Apo A1 was revealed to be an independent prognostic indicator through multivariate analysis. Combining the Apo A1 level, Zhongshan Score model was constructed with Lasso regression for prognosis prediction. This model exhibited higher accuracy than International Staging System (ISS) and Durie and Salmon (DS) system. In conclusion, among all the serum lipid profiles, serum Apo A1 is a powerful prognostic indicator for patients with MM.

Serum lipid profiles in patients with allergic rhinitis

INTRODUCTION: Inflammation is implicated in atherosclerotic cardiovascular disease. Allergy is a systemic inflammatory condition, and this may potentiate cardiovascular disease. One of the possible mechanisms for this effect can be dyslipidemia. We aim to study the association of allergic rhinitis (AR) with dyslipidemia. MATERIALS AND METHODS: A total of 260 patients, 134 with AR and 126 controls were included in the study. The venous samples after overnight fasting were analyzed biochemically for lipids. RESULTS: Serum total cholesterol (P = 0.0312), low-density lipoprotein (LDL) (P = 0.0324), very LDL (P = 0.0352), and triglyceride (P = 0.0417) levels were significantly higher in patients with AR as compared to the controls. However, the values of high-density lipids were not statistically significant (P = 0.0696). CONCLUSION: Patients with AR have abnormal lipid profiles, which may play a role in the future development of cardiovascular complications in these patients.

Variation in common serum lipid parameters in patients with malaria: A 1-year cross-sectional study

Background: Variations in serum lipid parameters are commonly and ubiquitously reported in patients with malaria. Different host cell lipid-dependent processes have been observed in the life cycle of the malarial parasite Plasmodium. Aim: The present study was undertaken to assess the serum lipid profile in patients with malaria. Materials and Methods: This 1-year cross-sectional study was conducted from January 2013 to December 2013 at the Department of Medicine. A total of 50 adult patients with positive-smear and quantitative buffy coat test for malaria, as well as with clinical features of malarial infection, were investigated for serum lipid profile changes. Patients on lipid-lowering drugs were excluded from the study. Fasting lipid profile estimation was performed using fully-automated Siemens Dimension Clinical Chemistry System for total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Data were analyzed using the independent sample t-test and one-way ANOVA. Results: Majority (86%) of the patients were positive for Plasmodium vivax. Thrombocytopenia was observed in 64% of the patients. Serum lipid profile estimation in these patients revealed that 60% of the patients had low total cholesterol levels (100–150 mg/dL), 56% of patients had low-LDL levels ( 150 mg/dL). Interestingly, patients with low-LDL cholesterol level had low-platelet count (51.25 ± 29.67;P = 0.035). Conclusion: Patients with malaria infections may have lipid parameters alteration in terms of hypocholesterolemia, low-HDL and -LDL levels, and hypertriglyceridemia.

Effects of a 12-week high intensity interval training on blood lipid of dyslipidemia patients with different apolipoprotein E genotypes

To evaluate the effects of 12 weeks high intensity interval training(HIIT) on serum lipids profile in patients with dyslipidemia of different apolipoprotein E(ApoE) genotypes. Eighty-eight patients with dyslipidemia were screened by fasting blood lipid as subjects. Apolipoprotein E genotypes were detected in oral mucosa of subjects. Serum lipids before and after 12 weeks high intensity interval training were measured to analysis the effect of high intensity interval training on serum lipids. Five genotypes were detected in 88 cases of dyslipidemia. The distributions were ApoE3/3＞ApoE3/4＞ApoE2/3＞ApoE2/2＞ApoE2/4,and allele ε3＞ε2=ε4. Before exercise intervention, the level of total cholesterol in patients with ε4 allele was significant higher than those in patients with ε2 and ε3 (P＜0.01), low density lipoprotein cholesterol in patients with ε4 was significant higher than that of patients with ε2 (P＜0.05), and the other indexes had no significant difference among the groups (P＞ 0.05). After 12 weeks high intensity interval training, the levels of total cholesterol, triglyceride and low density lipoprotein cholesterol were decreased significantly ,while the level of high density lipoprotein cholesterol was increased in those patients with ε3 genotype. For those individuals with ε4 genotype , their serum levels of total cholesterol and low density lipoprotein cholesterol were reduced after 12 weeks high intensity interval training , but there was no changes in serum levels of triglyceride and high density lipoprotein cholesterol. For those individuals with ε2 genotype, there was no significant improvement in serum lipids after 12 weeks high intensity interval training interventions. The polymorphisms of apolipoprotein E gene resulted in different effects of exercise interventions on serum lipids of dyslipidemia. Twelve weeks high intensity interval training can be used as an intervention method to regulate serum lipids of dyslipidemia with ε3 and ε4 alleles.

SERUM LIPOPROTEINS AND CHRONIC HEPATITIS C INFECTION;

Objectives: To determine the serum lipid profile in patients with chronic HCVinfection and correlation between serum lipid levels and liver histology. Material and methods:Descriptive study was carried out in Medical Unit I of Liaquat University Hospital JamshoroHyderabad, from September 2007 to August 2009. Convenience sampling was used and 30patients were selected. Positive PCR test for HCV, non diabetic patients and non cirrhotic patientswere included in this study. All the patients were selected from the medical OPD. Clinicalexamination performed and then blood tests were done. Serum lipid profile were determined inall participants after an overnight fast of 12 h. TC, TG, and HDL-C was measured enzymaticallywith commercial kits (Olympus System Reagent, Hamburg, Germany) by the use of anautomated analyzer. The body mass index (BMI) was calculated in accordance with the formulaof weight (kg) divided by height2 (m2). Selected patients were called in the ward and biopsy wasdone via Trucut needle and the specimen was fixed in formalin. The biopsies were used tocalculate the degree of steatosis (0-3) and fibrosis by METAVIR score. Results: A total of 30patients were selected for this study. Out of these 19 were males and 11 females. The patientswere divided in three groups. Patients with chronic HCV infection were found to have significantlylower levels of serum TC, HDL-C and LDL-C than normal adults values. Steatosis was present insignificant number of patients (36.67%). However, steatosis was not correlating with fibrosis(p&gt;0.005). Conclusions: Hypolipoproteinemia and steatosis are important factors which areassociated with chronic hepatitis C

Identification of High Serum Apolipoprotein A1 As a Favorable Prognostic Indicator in Patients with Multiple Myeloma

PurposeTo explore the prognostic significance of serum lipid profiles in patients with multiple myeloma (MM).Patients and methodsThe study retrospectively enrolled 307 MM patients in Zhongshan Hospital, Shanghai, China, from 2007 to 2016. We evaluated the prognostic significance of the prediagnostic serum lipid profile [cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), Apolipoprotein A1 (Apo A1) and Apolipoprotein B (Apo B)]. Prognostic factors identified through univariate and multivariate analysis were used to construct a new model based on Lasso Cox regression.ResultsIn our cohort, lipid levels showed significant difference between ISS stages (P<0.001 in cholesterol, P<0.001 in LDL, P=0.002 in HDL, P<0.001 in Apo A1, P<0.001 in Apo B). However, only Apo A1 showed statistically significance in overall survival (OS), progression free survival (PFS) and cause specific survival (CSS) (P=0.038, P=0.028, P=0.011) in univariate Cox regression. Patients with higher Apo A1 displayed longer OS (median OS, 67 months vs. 30 months; P<0.001). Also, Apo A1 was revealed to be independent prognostic parameters through multivariate analysis. Combining the Apo A1 level, a Zhongshan Score model was constructed with Lasso regression for prognosis prediction. This model exhibited higher accuracy than International Staging System (ISS) and Durie and Salmon (DS) system.ConclusionAmong all the serum lipid profiles, serum Apo A1 is a powerful prognostic indicator for patients with MM. DisclosuresNo relevant conflicts of interest to declare.

The relationship between plasma renin activity and serum lipid profiles in patients with primary arterial hypertension

Introduction:The aim of the study was to evaluate clinical and biochemical differences between patients with low-renin and high-renin primary arterial hypertension (AH), mainly in reference to serum lipids, and to identify factors determining lipid concentrations.Materials and methods:In untreated patients with AH stage 1 we measured plasma renin activity (PRA) and subdivided the group into low-renin (PRA < 0.65 ng/mL/h) and high-renin (PRA ⩾ 0.65 ng/mL/h) AH. We compared office and 24-h ambulatory blood pressure, serum aldosterone, lipids and selected biochemical parameters between subgroups. Factors determining lipid concentration in both subgroups were assessed in regression analysis.Results:Patients with high-renin hypertension (N = 58) were characterized by higher heart rate (p = 0.04), lower serum sodium (p < 0.01) and aldosterone-to-renin ratio (p < 0.01), and significantly higher serum aldosterone (p = 0.03), albumin (p < 0.01), total protein (p < 0.01), total cholesterol (p = 0.01) and low-density lipoprotein cholesterol (LDL-C) (p = 0.04) than low-renin subjects (N = 39). In univariate linear regression, only PRA in the low-renin group was in a positive relationship with LDL-C (R2 = 0.15, β = 1.53 and p = 0.013); this association remained significant after adjustment for age, sex, and serum albumin and aldosterone concentrations.Conclusions:Higher serum levels of total and LDL-C characterized high-renin subjects, but the association between LDL-C level and PRA existed only in low-renin primary AH.

99. Concomitant intrauterine growth restriction alters the lipoprotein profile in preeclampsia

Preeclampsia (PE) is a heterogeneous disorder that can be subgrouped according to clinical and pathophysiological features. PE can be accompagnied by intrauterine growth restriction (IUGR) and both diseases share common features. Alterations in lipid metabolism have consistently been reported for both diseases. We investigated whether characteristic lipid changes can be related to either of both diseases. We hypothesized that in general IUGR displays a low cholesterol phenotype while pure PE is rather associated with high triglyceride concentrations. Serum lipid profile of patients with IUGR (n = 52), hypertensive IUGR (HIUGR, n = 28), and PE without IUGR (n = 56) were compared to a control group (CTRL, n = 167). Additionally, lipid components in serum of severe early-onset cases (<34th weeks of gestation) of normotensive IUGR, hypertensive IUGR (HIUGR), and PE without IUGR (each n = 10) were analyzed by extensive lipid subfractionation and compared to 30 control patients. Triglycerides are elevated in PE. However in IUGR LDL-cholesterol is reduced, irrespective of additional PE (IUGR 79 mg/dL; HIUGR 74 mg/dL vs. CTRL 133 mg/dL). The ApoB-profile shows a higher level of VLDL-ApoB in PE and a lower level of LDL-ApoB in IUGR, as expected. Interestingly, the HIUGR group shows features of both groups, high VLDL-ApoB level and a low ApoB-level in the LDL-subfractions. The presence of IUGR in PE alters lipid profiles. Study groups have to be selected carefully to avoid misinterpretation.

Evaluation of liver fibrosis using bioelectrical impedance analysis and serum lipid profiles in patients with hepatitis c treated with direct acting antivirals

Evaluation of liver fibrosis using bioelectrical impedance analysis and serum lipid profiles in patients with hepatitis c treated with direct acting antivirals

Assessment of Serum Lipid Profile in patients with chronic Hepatitis C

Assessment of Serum Lipid Profile in patients with chronic Hepatitis C

Efekty`vnist` vply`vu seredn`odozovoyi staty`noterapiyi na pokazny`ky` lipidnogo spektra krovi u xvory`x na stabil`nu ishemichnu xvorobu sercya, poyednanu z nealkogol`noyu zhy`rovoyu xvoroboyu pechinky` u stadiyi steatozu

Efekty`vnist` vply`vu seredn`odozovoyi staty`noterapiyi na pokazny`ky` lipidnogo spektra krovi u xvory`x na stabil`nu ishemichnu xvorobu sercya, poyednanu z nealkogol`noyu zhy`rovoyu xvoroboyu pechinky` u stadiyi steatozu

Targeted lipidomics analysis identified altered serum lipid profiles in patients with polymyositis and dermatomyositis

BackgroundPolymyositis (PM) and dermatomyositis (DM) are severe chronic autoimmune diseases, characterized by muscle fatigue and low muscle endurance. Conventional treatment includes high doses of glucocorticoids and immunosuppressive drugs; however, few patients recover full muscle function. One explanation of the persistent muscle weakness could be altered lipid metabolism in PM/DM muscle tissue as we previously reported. Using a targeted lipidomic approach we aimed to characterize serum lipid profiles in patients with PM/DM compared to healthy individuals (HI) in a cross-sectional study. Also, in the longitudinal study we compared serum lipid profiles in patients newly diagnosed with PM/DM before and after immunosuppressive treatment.MethodsLipidomic profiles were analyzed in serum samples from 13 patients with PM/DM, 12 HI and 8 patients newly diagnosed with PM/DM before and after conventional immunosuppressive treatment using liquid chromatography tandem mass spectrometry (LC-MS/MS) and a gas-chromatography flame ionization detector (GC-FID). Functional Index (FI), as a test of muscle performance and serum levels of creatine kinase (s-CK) as a proxy for disease activity were analyzed.ResultsThe fatty acid (FA) composition of total serum lipids was altered in patients with PM/DM compared to HI; the levels of palmitic (16:0) acid were significantly higher while the levels of arachidonic (20:4, n-6) acid were significantly lower in patients with PM/DM. The profiles of serum phosphatidylcholine and triacylglycerol species were changed in patients with PM/DM compared to HI, suggesting disproportionate levels of saturated and polyunsaturated FAs that might have negative effects on muscle performance. After immunosuppressive treatment the total serum lipid levels of eicosadienoic (20:2, n-6) and eicosapentaenoic (20:5, n-3) acids were increased and serum phospholipid profiles were altered in patients with PM/DM. The correlation between FI or s-CK and levels of several lipid species indicate the important role of lipid changes in muscle performance and inflammation.ConclusionsSerum lipids profiles are significantly altered in patients with PM/DM compared to HI. Moreover, immunosuppressive treatment in patients newly diagnosed with PM/DM significantly affected serum lipid profiles. These findings provide new evidence of the dysregulated lipid metabolism in patients with PM/DM that could possibly contribute to low muscle performance.

Assessment of Serum Lipid Profile in Patients of Coronary Artery Disease: A Case-Control Study

Assessment of Serum Lipid Profile in Patients of Coronary Artery Disease: A Case-Control Study

Serum Lipid Profile in Diffuse versus Limited Systemic Sclerosis Data from the SASS cohort

Data about lipoprotein changes and their link with cardiovascular disease and atherosclerosis in systemic sclerosis (SSc) are still challenging. We aimed to evaluate serum lipid profile of patients with SSc and to identify potential relation with different disease specific characteristics (clinical, serological, inflammatory tests) in a cross-sectional study. Standard assessments comprised SSc-related parameters (disease subtype, clinical spectrum, immunological tests) and lipid metabolism (total cholesterol and fractions, triglycerides). Impaired lipid profile (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, slightly modification in total cholesterol level) significantly correlated with diffuse SSc, activity (EUSTAR) and severity (MEDSGER), as well as seropositivity for specific antibodies (anti-centromere and anti-topoisomerase 1). The dyslipidemic profile might represent a pathobiological pathway for atherosclerosis in SSc.

Assessment of Serum Lipid Profile in Patients Undergoing Cholecystectomy

Assessment of Serum Lipid Profile in Patients Undergoing Cholecystectomy

A Comparative Study of Biliary and Serum Lipid Profiles in Patients of Obstructive jaundice due to stones in common bile duct

A Comparative Study of Biliary and Serum Lipid Profiles in Patients of Obstructive jaundice due to stones in common bile duct

Estimation of serum lipid profile in patients with OSMF

Aim: This study was done to evaluate the alteration in serum lipid profile pattern in patients with oral submucous fibrosis, with various histological grades of Oral Sub Mucous Fibrosis along with controls. Materials and Methods: The study included 150 participants, out of those 120 were having oral submucous fibrosis, and 30 cases of controls matched for age and sex were selected from the routine patients attending the Department of Oral Medicine and Radiology. Serum lipids, including total cholesterol (TC), LDL cholesterol (LDLC), HDL cholesterol (HDLC), VLDL cholesterol (VLDLC), and triglycerides (TG) were analyzed using kit ACCUREX [Bio-medicals limited, India] as per the instructions provided by manufacturer using SEMI AUTO ANALYSER [Tulip Coral 3000 Indian]. Statistical Analysis Used: Data were summarized as Mean ± SD (standard deviation). Groups were compared by Student's t-test. Groups were also compared by one way analysis of variance (ANOVA) and the significance of mean difference between (inter) the groups was done by Tukey's HSD (honestly significant difference) post hoc test after ascertaining normality by Shapiro–Wilk's test and homogeneity of variance between groups by Levene's test. A two-tailed (α = 2) P