Serum Lipid Profile In Adults Research Articles

Assessment of Serum Lipid Profile Among Patients With Hemorrhagic Versus Ischemic Strokes at Muzaffarabad; A Comparative Study

Objective: To assess the serum lipid level in adults with hemorrhagic versus ischemic stroke and determine the associated factors. Methodology: A Comparative cross-sectional study was conducted at the Department of General Medicine, Combined Military Hospital Muzaffarabad, Azad Kashmir from 30-3-2020 to 30-9-2020. Out of 100 patients were enrolled and divided into two different groups. 3ml of blood was drawn and sent for fasting lipid profile to the single institutional laboratory. The blood samples were analyzed enzymatically using an autoanalyzer. All the obtained information was analyzed using SPSS. Results: In ischemic stroke patients, the mean TC was 227.20±16.47 mg/dl; among hemorrhagic stroke patients, mean total cholesterol levels were 203.5 ±16.8 with the value of P=<0.001. The Total mean HDL was found 36.10±4.29 with a value of p=<0.001. In ischemic stroke patients, the mean LDL was 145.18±16.98; in hemorrhagic stroke patients, the mean LDL was 131.96±12.12 (p-value=<0.001). In ischemic stroke patients, the mean TG was 203.18±57.74 mg/dl while in hemorrhagic stroke patients, the mean TG was 164.67±53.25 with a value of p=0.001) Conclusion: This study concluded that the mean TC, HDL, LDL, and TG of the patients was 215±20.42 mg/dl, 37.77±4.47 mg/dl, t 138.57±16.11 mg/dl, and 183.93±58.55 mg/dl respectively. This study further concluded that is substantial correlation exists between the serum lipid profile of adults and the type of stroke

Exploratory analysis of the associations between neonicotinoids insecticides and serum lipid profiles among US adults: A cross-sectional, population-based study

Neonicotinoid insecticides (NNIs) are widely used in agriculture, horticulture, forestry, and household environment, but their potential impact on human health remains a subject of concern. This study aimed to investigate the relationship between NNIs and their metabolites in urine with serum lipid profiles in adults using data from the National Health and Nutrition Examination Survey (NHANES) 2015–2016. The study included 1192 participants aged over 20 years with urinary NNIs levels, serum lipid parameter levels and potential confounders. Urinary concentrations of NNIs, including imidacloprid, acetamiprid, clothianidin, thiacloprid, N-desmethyl-acetamiprid, and 5-hydroxy-imidacloprid, were quantified. Serum lipids profiles, such as total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (Apo-B), were assessed. Considering the effects of lipid-lowering medications, the censored normal regression model was used to explore the associations between urinary NNIs and TC, TG, HDL-C, LDL-C and Apo-B levels. The results revealed a significant increase of 9.0 mg/dL (95%CI: 2.0, 16.1) in TC levels among participants with detectable N-desmethyl-acetamiprid compared to those with undetectable levels. Stratified analysis indicated that the association between N-desmethyl-acetamiprid and HDL-C levels was more pronounced among participants aged ≥ 46 years compared to those aged between 20 and 45 years with undetectable N-desmethyl-acetamiprid (pinteraction=0.044). Additionally, there were marginal effect modification of BMI on the association between N-desmethyl-acetamiprid and LDL-C (pinteraction=0.097) and Apo-B (pinteraction=0.052) levels. Specifically, participants with BMI ≥ 25 kg/m² and detectable N-desmethyl-acetamiprid tended to have higher LDL-C and Apo-B levels compared to those with BMI < 25 kg/m² and undetectable N-desmethyl-acetamiprid. However, no significant associations were observed between other NNIs and lipid profiles in the present study. To validate these findings, further longitudinal studies with larger sample sizes should be conducted, particularly within populations characterized by a high detection rate of NNIs.

Polymorphism rs3737787 of Upstream Stimulatory Factor 1 gene is associated with serum lipid phenotype in Nigerian population

Serum lipid profile which is determined by genotype-phenotype relationship plays a significant role in the development of cardiovascular disease. Upstream stimulatory factor 1 (USF1), has been reported to be associated with serum lipid levels in different population, hence, this study investigated the association of variants in USF1 with serum lipid profile in adults in Lagos state, Nigeria. We genotyped rs3737787 (11235C > T) and rs550376620 (10488G > A) with PCR-RFLP in 384 participants and we used logistic regression to assess the association of these variants with serum lipid levels. The minor allele frequency observed in 10488G > A in both case and control groups was 5% while the minor allele of 11235C > T was observed to be more frequent in the control when compared to the dyslipidemic subjects (24% vs 12%; p = 1.84e-05). Levels of total cholesterol, triglycerides, and LDL-c in dyslipidemic subjects with CC genotype of 11235C > T were significantly higher compared to CT and TT genotypes (p < 0.001; p < 0.0001 and p < 0.0001 respectively). Logistic regression with adjustment for age, gender and BMI, showed that the minor allele carriers of 11235C > T have a reduced risk of dyslipidemia (Odds ratio: 0. 0.043, 95% confidence interval (CI): (0.006–0.331, p = 0.002). Our findings revealed that rs3737787 is associated with lipid phenotype in Nigerian population.

Comparative analysis of serum lipid profile in adults with and without acne vulgaris in a tertiary care center in South India

Background: Acne is a chronic inflammatory disease of the pilosebaceous unit, affecting most teenagers during adolescence and at times may persist into adulthood also. Sebum analysis in some studies has shown increased triglycerides and wax/cholesterol esters in acne patients. Whether there is local alteration of surface lipids and seborrhea associated with any alteration of serum lipid profile in acne patients is not yet known. However, few studies in acne patients have shown definitive variations in lipid profile providing insights into plausibility of role of altered serum lipid levels in acne. Aims: The aim was to evaluate serum lipid profile in adults with and without acne vulgaris and to study the correlation between lipid profile and severity of acne in Indian patients. Materials and Methods: Fifty male and female adults presenting with acne aged between 18 and 40 years along with age- and sex-matched healthy adults without acne were subjected for serum lipid level analysis. Results: In this study, there was no significant difference in lipid levels in acne patients compared to control. Limitations: The limitation of the study was small sample size. Conclusions: There is no statistically significant increase in total cholesterol, very low-density lipoprotein, and low-density lipoprotein in acne patients compared to control.

The Effects of Mindfulness Meditation Program on Perceived Stress, Stress Response, Serum Lipid Profile in Adults with Dyslipidemia

The Effects of Mindfulness Meditation Program on Perceived Stress, Stress Response, Serum Lipid Profile in Adults with Dyslipidemia

Contribution of Eggs and Other Cholesterol-containing Foods to Total Dietary Cholesterol Intake, and Their Influence on Serum Lipid Profile of Adults in Calabar, Nigeria

Aim: Eggs have sometimes been regarded as unhealthy foods due to their relatively high cholesterol content. The aim of this study is to determine contribution of eggs and other cholesterol containing food to total dietary cholesterol and their influence on serum lipid profile of adults.&#x0D; Study Design: Cross sectional and experimental.&#x0D; Place and Duration of Study: Department of Biochemistry, University of Calabar, Calabar. February to July 2017.&#x0D; Methodology: A cross-sectional survey to determine consumption pattern was carried out on 400 respondents using food frequency questionnaire (FFQ) and 24 hour dietary recall. The respondents were further grouped into four based on their reported weekly egg consumption. A detailed follow-up study was conducted on 50 participants selected from across the 4 groups, using a 3-day repeated 24 hour dietary recall to determine their consumption of egg and other cholesterol-containing foods. Serum blood lipid profile of these 50 participants was also determined using Randox cholesterol test kits. Food composition tables were used to calculate dietary cholesterol intake (DCI). The mean DCI of the 4 groups were cross-tabulated with mean serum cholesterol levels. Percentage contribution of eggs and other frequently consumed cholesterol-containing foods (such as milk and fish) to total DCI was calculated. Statistical significance was accepted at p = .05.&#x0D; Results: For the follow-up participants, it was observed that results of correlations between DCI and the lipid profile parameters showed negative correlation (at p = .01) in both males and females, except slight positive correlations between cholesterol intake and HDL-c (r=0.191) among the males, and cholesterol with TC (r=0.265) among the females. Apart from this, no association was observed between DCI and the lipid profile parameters. Furthermore, the &gt; 5eggs/week group had the lowest TC and LDL-c (4.23±0.19 mmol/L and 2.38±0.10 mmol/L). Based on the respondents’ consumption patterns, eggs (boiled and fried) contributed the highest- 34.8% to total DCI, followed by milk (15.9%); salad cream contributed lowest (0.3%) to total DCI.&#x0D; Conclusion: Increased DCI from cholesterol-containing foods (such as eggs), did not cause an adverse increase in serum cholesterol levels of normocholesterolemic people.

Are dietary amino acids prospectively predicts changes in serum lipid profile?

BackgroundBesides of dietary fat and carbohydrate, amino acids(AAs), as constituent components of dietary protein have been related with serum lipid levels. This study aims to examine the association between dietary AAs and prospective changes in serum lipid profile in adults. MethodsAnalyses were conducted on 3881 participants aged, 18–75 years of Tehran lipid and Glucose study, at baseline (2008–2011) and were followed for 3 years (2011–2014) to ascertain serum lipid profile changes. Dietary intakes of AAs were collected at baseline using food frequency questionnaire. Multiple linear regression adjusted for age, sex, body mass index, physical activity, smoking and daily intakes of energy, total fat, and fiber were used. ResultsThe median(IQR) changes in triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were 6.0(-19.0, −35.5), 9.0(7.0, −24.0), 1.0(-3.0, −6.0), and 5.2(-8.0, −18.6) mg/dl, respectively. Higher intakes of isoleucine, lysine, tyrosine, alanine, threonine, methionine, valine, histidine, aspartic acid, and branched chain, alkaline, and alcoholic AAs were positively associated with TGs-changes in the final adjusted model, whereas tryptophan, glutamic acid, and acidic AAs were negatively related to TG-changes. Alanine and tryptophan were associated with higher and lower LDL-C-changes, respectively. Lysine, alanine, methionine, aspartic acid, and alkaline AAs showed positive association with changes in TC, whereas tryptophan and glutamic acid had a negative association with TC-changes. ConclusionOur findings showed that some dietary amino acids have the potential to increase or decrease serum lipid profile.

Capsaicin Supplementation Improved Risk Factors of Coronary Heart Disease in Individuals with Low HDL-C Levels.

Low high-density lipoprotein cholesterol (HDL-C) is associated with an increased risk of coronary heart disease (CHD). This study aimed to evaluate the effects of capsaicin intervention on the serum lipid profile in adults with low HDL-C. In a randomized, double-blind, controlled clinical trial, 42 eligible subjects were randomly assigned to the capsaicin (n = 21, 4 mg of capsaicin daily) or to the control group (n = 21, 0.05 mg of capsaicin daily) and consumed two capsaicin or control capsules, which contained the powder of the skin of different peppers, twice daily for three months. Thirty-five subjects completed the trial (18 in the capsaicin group and 17 in the control group). The baseline characteristics were similar between the two groups. Compared with the control group, fasting serum HDL-C levels significantly increased to 1.00 ± 0.13 mmol/L from 0.92 ± 0.13 mmol/L in the capsaicin group (p = 0.030), while levels of triglycerides and C-reactive protein and phospholipid transfer protein activity moderately decreased (all p < 0.05). Other lipids, apolipoproteins, glucose, and other parameters did not significantly change. In conclusion, capsaicin improved risk factors of CHD in individuals with low HDL-C and may contribute to the prevention and treatment of CHD.

Does CTHRC1 Affect Serum Lipid Profiles in Adults?

PURPOSE: Obesity has become a global public health concern as evidence mounts that it is related to a large variety of life threatening diseases from diabetes to heart disease. The biochemical links between body composition and hypercholesterolemia are a target of ongoing research. The hormone collagen triple helix repeat containing 1 (CTHRC1) has been shown to play an important role in the regulation of body composition in mouse models. This study aimed to compare CTHRC1 and serum lipid panels in human adults. We hypothesized that higher CTHRC1 levels would be associated with both decreased cholesterol and triglycerides (TG). METHODS: This study was done in collaboration with researchers at the University of South Carolina who completed the Energy Balance Study (EBS) on 430 adult subjects age 21-35, with BMI ranging from 20-35. Deidentified baseline plasma samples from the EBS subjects were analyzed with enzymatic calorimetric testing and ELISA to measure lipid panels (total cholesterol, HDL, LDL, triglycerides) and CTHRC1 concentrations respectively. Statistical analysis software was used to compare the data both generally and within clinically accepted subgroups of lipid concentrations. RESULTS: Of the 430 samples from the EBS subjects, 310 contained sufficient plasma for both CTHRC1 and lipid panel testing. No statistically significant difference in lipid concentrations was found between detectable and undetectable CTHRC1 groups (p=0.17-0.99). Stratification of CTHRC1 into undetectable, middle 75% and top 25% also showed no significant difference in lipid concentrations (p=0.32-0.79), nor did stratification of lipid panel components into clinically relevant subgroups (total cholesterol </>200, HDL </>40, LDL </>100, TG </>150, p=0.12-0.94). Lastly, linear regression models showed no correlation between CTHRC1 and lipid concentrations (p=0.21-0.93). CONCLUSION: This study demonstrates no association between CTHRC1 and lipid concentrations in a sample of relatively healthy human adults. Further research is required to better understand the temporal variation of CTHRC1 levels in vivo and thus, better time the collection of samples from subjects. Furthermore, a broader range of body composition among future subjects will help to better generalize data to the adult population.

다시마 첨가 패티가 경계역 고콜레스테롤혈증 성인의 식후 혈청 지질 및 혈당 농도에 미치는 영향

Sea tangle (Laminaria japonica) is well known as having anti-diabetic and hypolipidemic effects in animals as well as in humans. In this study, we evaluated the effects of sea tangle-added patty on postprandial blood glucose and lipid profiles in borderline-hypercholesterolemic (cholesterol ≥200 mg/dL) adults. Eleven subjects volun- tarily participated in the experiment, and each subject provided written consent. Experimental patty (E) was made by adding 2.25 g of sea tangle powder as a substitution to 1.125 g each of pork and chicken. In the first week, 200 g of Control patty (C) was provided to each subject, who had fasted more than 12 hours. In the second week, the same amount of E patty was supplied under the same conditions. Serum glucose levels increased significantly less at 30, 60, and 120 min after consumption of E patty compared to the levels at all time points after eating C patty. Thus, the change in the area under curve (ΔAUC) of serum glucose levels through 120 minutes was lower when consuming E patty compared to C patty. Although serum C-peptide concentrations were not significantly different at all time points between the two patties, the ΔAUC of serum C-peptide concentrations through 120 minutes was lower when consuming E patty compared to C patty. However, there were no differences in serum levels of triglyceride, total cholesterol, LDL-C, and HDL-C at 30, 60, 120, 180, and 240 min between the two patties. Further, each ΔAUC of these lipid levels through 240 minutes was not significantly different between the two patties. The results indicate that sea tangle-added patty may decrease postprandial plasma glucose concentrations and reduce insulin secretion, although it might not ameliorate serum lipid profiles in adults with borderline-hypercholesterolemia.

A study of correlation between iron deficiency anaemia and serum lipid profile in Indian adults in BRIMS, Bidar

Background: Both iron deficiency anemia and dyslipidaemia are widely prevalent public health problems, especially in the Indian population. Some link has been suggested between the two potentially morbid conditions but a sufficient Indian study could not be found in this regard. Methods: This study was planned to find the changes in serum lipid profile in adult Indian patients with iron deficiency anemia and the effect of oral iron therapy on them. 100 iron deficiency anemia and 70 age and sex matched healthy controls, in the age group 18-35 years were investigated for any possible changes in serum lipid profile i.e., triglycerides, total cholesterol, high density lipoprotein cholesterol, very low density lipoprotein cholesterol. The patients were followed up after 3 months of oral iron therapy. Results: The results are shown as mean± standard deviation. Triglycerides and very low density lipoprotein cholesterol levels were found to be significantly (P <0.001) elevated in the iron deficiency anemia group (151.87 ± 48.06 mg/dl and 30.40 ± 9.71 mg/dl) as compared to controls (109.99 ± 30.81 mg/dl and 21.96 ± 6.69 mg/dl), whereas level of low density lipoprotein cholesterol were found to be significantly (P = 0.02) lower in patients (90.96 ± 41.55 mg/dl) as compared to controls (105.24 ± 26.45 mg/dl). However, after treatment (in 43 patients) there was significant (P <0.001) reduction in the levels of triglycerides and very low density lipoprotein cholesterol (111.56 ± 26.87 mg/dl and 22.30 ± 5.36 mg/dl) when compared to their pretreatment level (154.70 ± 53.89 mg/dl and 30.93 ± 10.84 mg/dl), whereas low density lipoprotein cholesterol levels did not show any significant change. Conclusion: These findings indicate that iron deficiency anemia in Indian adults is attended by abnormal serum lipid profile, which responds significantly to iron therapy.