AIM:To study the effects and clinical significance of parenteral hyperalimentation on levels of serum motilin, peptide YY, IgG and glycoproteins in patients with severe ulcerative colitis. METHODS:Eighty-nine patients (males 51,females 38,age 23-57 years) with severe ulcerative colitis were examinated with colonoscope, barium enema, the diagnosis was confirmed histologically. Bacterial infection was excluded through twice consecutive stool cultures. And ameba, schistosomiasis, gastroentertinal cancer and endocrine diseases were also excluded. Ulcerative colitis was found in sigmoid (n =45), descending colon (n =21), colon splenic flexure (n =15) and transverse colon (n =8). Its clinical categories included relapse (n =44), persistent (n =30) and initial (n =15). Parenteral hyperalimentation was applied to patients once diagnosis was made; three days later, fasting venous blood was drawed to test serum motilin (MTL), peptide YY (PYY) and IgG by radioimmunoassy, and serum α1, α2 and γ glycoproteins by electrophoresis. RESULTS:After 4-week period therapy with parental hypernutrition,27 cases (30 %) recovered completely, 48 (54 %) improved, and 14(16 %) failed to therapy, the total effective rate was 84 %. Level of serum MTL, PYY, IgG, and α1-glycoprotein in colitis patients were significant higher than those in control, α 2-glycoprotein was lower than that in control ( P 0.05).Level of serum albumin was increased (P <0.05),and the histological change in ulcerative colitis was significantly improved after treatment. CONCLUSION:The parenteral hyperalimentation therapy improved effectively serum levels of motilin, PYY, IgG and glycoproteins in patients with severe ulcerative colitis. Guo XG, Sun AH, Li CN, Zhang HB, Zhou XM, Xu CT, Pan BR. Effects of parenteral hyperalimentation on serum motilin, peptide YY,IgG and glycoproteins in severe ulcerative colitis. Shijie Huaren Xiaohua Zazhi, 2003;11 (2):224-228