s / Drug and Alcohol Dependence 140 (2014) e169–e251 e221 nence. While it is unclear whether these differences were due to improved attention, these results suggest that IB may help to improve cognitive function in early MA withdrawal. Data provide some support for developing MA treatments that reduce cognitive impairment. Financial support: National Institute on Drug Abuse (1R01DA029804; S. Shoptaw); National Center for Advancing Translational Sciences (UL1TR000124; S. Dubinett). http://dx.doi.org/10.1016/j.drugalcdep.2014.02.612 A systematic review of studies exploring craving, its moderators, and the link with substance use in daily life using Ecological Momentary Assessment (EMA) J. Swendsen2, F. Serre1,3, M. Fatseas1,3, Marc Auriacombe1,3 1 Addiction Psychiatry, University Bordeaux/CNRS USR 3413, Bordeaux, France 2 CNRS UMR 5287 INCIA, University Bordeaux, Bordeaux, France 3 CH Ch. Perrens et CHU Bordeaux, Bordeaux, France Aims: Studies examining the link between craving and substance use have often revealed contradictory results. Ecological MomentaryAssessment (EMA) is amethodparticularlywell-suited to assess subjective variables and episodic events in daily life, and it offers a new opportunity to examine questions concerning craving with high ecological validity. The objective of this systematic review was to examine all published studies using EMA to: (1) examine the temporal link between craving and substance use, and (2) identify relevant moderators of craving intensity among substance users. Methods: The literature searchusedMedlineup to July31, 2012, and was based on a systematic review methodology. Results: Fifty-seven studies were selected, of which most concerned tobacco or alcohol. The majority of studies (91%) reported a positive relationship between craving and substance use, both concurrently and prospectively, within preand post-quit periods, among users with different levels of use, and for both legal and illegal substances. EMA data also confirmed the influence of intra-individual variables (negative affects, social contexts, other substance use) and inter-individual variables (age, level of use) in daily life craving reports Conclusions: This review of EMA investigations demonstrates a strong link between craving and substance use, and underscores the importance of taking into account temporal and contextual considerations in the assessment of this relationship. Financial support: PHRC 2006, MILDT 2010, CRA 2009, PRACNRS-CHU 2008, CNRS ATIP. http://dx.doi.org/10.1016/j.drugalcdep.2014.02.613 Lower Serotonin 2C receptor (5-HT2CR) expression in the ventral tegmental area (VTA) associates with elevated cue reactivity following extended forced abstinence from cocaine-taking Sarah E. Swinford, Noelle C. Anastasio, R.G. Fox, S.J. Stutz, K.A. Cunningham Ctr Addiction Res, UTMB, Galveston, TX, United