Serological Markers Of Celiac Disease Research Articles

Serological markers of celiac disease in autoimmune liver disease patients: [formula omitted]∗, J Murray∗, DR LaBrecque∗, A Hammed†, and K Horvath†. ∗Univ. of Iowa Dept. of Medicine Iowa City, IA and †Univ. of Maryland Dept. of Pediatric Gastroenterology & Nutrition, Baltimore, MD

Serological markers of celiac disease in autoimmune liver disease patients: [formula omitted]∗, J Murray∗, DR LaBrecque∗, A Hammed†, and K Horvath†. ∗Univ. of Iowa Dept. of Medicine Iowa City, IA and †Univ. of Maryland Dept. of Pediatric Gastroenterology & Nutrition, Baltimore, MD

Anti‐endomysium and anti‐gliadin antibodies as serological markers for coeliac disease in childhood: a clinical study to develop a practical routine

Anti-gliadin and anti-endomysium antibodies were analyzed in 174 children with suspected or verified coeliac disease with the aim of developing a practical routine. The biopsy was performed without knowledge of the antibody levels. To screen for coeliac disease is children younger than 2 years, we suggest the use of IgA anti-gliadin antibodies, giving a sensitivity of 100% and a specificity of 86%. In older children both tests should be used in parallel, i.e. a biopsy should be performed if at least one of the tests is positive, giving a sensitivity of 98% and a specificity of 81%. To avoid unnecessary biopsy before mucosal relapse can be demonstrated during gluten challenge in a child without clinical symptoms, we suggest that the tests are used as serial testing, i.e. a biopsy should be performed if both tests are positive.

Serological Markers and Celiac Disease

We analyze the diagnostic efficacy of two celiac disease serological markers: anti-gliadin (IgA and IgG class) and anti-endomysium IgA-class (EmA-IgA) antibodies applied to 336 serum samples from celiac patients on both gluten-challenge and gluten-free diets, and a control group. The anti-gliadin and anti-endomysium antibodies levels were significantly higher among the gluten-consuming celiac patients than in the other groups. The greatest efficacy in diagnosing celiac disease was achieved in the Ema-IgA class test. The IgA-class anti-gliadin antibodies proved to be more specific, with a higher positive test predictive value than the IgG-class anti-gliadin antibodies, whereas the latter proved to be more sensitive, with a higher negative test predictive value than those of the IgA-class anti-gliadin antibodies. Our results also demonstrate that the simultaneous assessment of anti-gliadin IgA- and IgG-class antibodies constitutes a valid test in selecting patients suspected of having celiac disease. In turn the EmA-IgA antibodies constitute a confirmative test for indication of an intestinal biopsy.

Serological Markers and Celiac Disease

SummaryWe analyze the diagnostic efficacy of two celiac disease serological markers: anti‐gliadin (IgA and IgG class) and anti‐endomysium IgA‐class (EmA‐IgA) antibodies applied to 336 serum samples from celiac patients on both gluten‐challenge and gluten‐free diets, and a control group. The anti‐gliadin and anti‐endomysium antibodies levels were significantly higher among the gluten‐consuming celiac patients than in the other groups. The greatest efficacy in diagnosing celiac disease was achieved in the Ema‐IgA class test. The IgA‐class anti‐gliadin antibodies proved to be more specific, with a higher positive test predictive value than the IgG‐class anti‐gliadin antibodies, whereas the latter proved to be more sensitive, with a higher negative test predictive value than those of the IgA‐class anti‐gliadin antibodies. Our results also demonstrate that the simultaneous assessment of anti‐gliadin IgA‐ and IgG‐class antibodies constitutes a valid test in selecting patients suspected of having celiac disease. In turn the EmA‐IgA antibodies constitute a confirmative test for indication of an intestinal biopsy.