DM outcomes represent one of the largest avoidable cost burdens with opportunity for improvement in the U.S. health care system. Improving health equity in the context of DM will require targeted community improvements, infrastructure investments, and policy interventions that are designed to maximize the impact of resource allocation through the use of available data and computational resources. By using an Artificial Intelligence approach to evaluate over 2000 socio-economic and infrastructural predictors of DM mortality, this study used a specific series of modeling techniques to identify significant predictors without human selection and compare their predictive ability with all possible factors when passed through artificial neural networks. The final regression model using zip code and county level predictors had an R2 of 0.863. Significant predictors included: Population % White, Population % Householders, Population % Spanish spoken at home, Population % Divorced males, Population % With public health insurance coverage, Population % Employed with private health insurance coverage, Manufacturing-Dependent Designation, Low Education Designation, Population % Medicare Part A and B Female Beneficiaries, Number of Short Term General Hospitals with 50-99 Beds. Using a multi-layered perceptron to predict zip codes at risk the C-statistic for all 2000+ predictors was 0.7938 while the 13 selected predictors was 0.8232. This indicates that these factors are highly relevant for DM mortality in Florida. This process was completed without the need of human variable selection and indicates how AI can be used for informative precision public health analyses for targeted population health management efforts. Disclosure A. Cistola: None.