Robotic manipulators inevitably experience the impact of uncertainties and errors, such as dimensional tolerances and joint clearances. Therefore, this paper proposes a novel method based on an interval approach to evaluate the kinematic reliability of manipulators. Kinematic reliability quantifies the probability of positioning errors that fall within allowable boundaries. As a result, reliability evaluates the probability that the interval end-effector error produced by dimensional tolerances exceeds an acceptable rate. The proposed reliability index is based on the interval error that conveys an alternative approach to the kinematic reliability methods based on probabilistic frameworks reported in the literature based on probabilistic approaches. The obtained numerical results demonstrate the viability of the proposed methodology by evaluating the reliability of a serial manipulator subjected to joint clearances and a parallel manipulator with dimensional tolerances.