e16037 Background: Concurrent chemotherapy and radiation therapy (CCRT) is the standard treatment of patients (pts) with advanced nasopharyngeal cancer (LANPC). Sequential treatment strategy with ICT helps improve local function, pain control and reduction of systemic failure. We report our limited experience of ICT with DPF regimen in a sequential treatment strategy of patients with LANPC. Methods: The data was recorded following chart review of pts treated for LANPC at the University of Connecticut Health Center between 2004-2010 following approval by the Institutional Review Board. Analysis included age of the pt, stage of the cancer, histological diagnosis; number of ICT cycles, response to treatment as complete disappearance of disease (CR) or more than 50% reduction of the disease (partial response PR), assessed both clinically and with imaging studies. Overall survival (OS) was defined as time from diagnosis to the last follow up, disease free survival (DFS) was defined as time from complete remission of the disease to the last follow up in CR. Results: 5 pts with LANPC were treated sequentially with DPF regimen followed by CCRT. The median age is 55 years, 4 males and one female. All pts had stage IV B, non keratinizing poorly differentiated histology. Average number of DPF ICT was 3. 4 out of 5 pts achieved CR while one pt achieved PR. With a median follow up period of 24 mths, four pts are alive in CR and one pt in PR died of tumor progression. The median DFS in four pts in CR is 16 mths (range 8-70 mths) and overall survival is 24 mths (range 12-74). Conclusion: DPF is well tolerated and effective ICT regimen in patients with LANPC. More studies will help understand the clinical relevance of this regimen as ICT in a sequential treatment of LANP.