Let L ( X , Y ) stand for the space of all bounded linear operators between real Banach spaces ( X , ‖ ⋅ ‖ X ) and ( Y , ‖ ⋅ ‖ Y ) , and let Σ be a σ-algebra of subsets of a non-empty set Ω. Let L ∞ ( Σ , X ) denote the Banach space of all bounded strongly Σ-measurable functions f : Ω → X equipped with the supremum norm ‖ ⋅ ‖ . A bounded linear operator T from L ∞ ( Σ , X ) to a Banach space Y is said to be σ-smooth if ‖ T ( f n ) ‖ Y → 0 whenever ‖ f n ( ω ) ‖ X → 0 for all ω ∈ Ω and sup n ‖ f n ‖ < ∞ . It is shown that if an operator measure m : Σ → L ( X , Y ) is variationally semi-regular (i.e., m ˜ ( A n ) → 0 as A n ↓ ∅ , where m ˜ ( A ) stands for the semivariation of m on A ∈ Σ ), then the corresponding integration operator T m : L ∞ ( Σ , X ) → Y is σ-smooth. Conversely, it is proved that every σ-smooth operator T : L ∞ ( Σ , X ) → Y admits an integral representation with respect to its representing operator measure. We prove a Banach–Steinhaus type theorem for σ-smooth operators from L ∞ ( Σ , X ) to Y. In particular, we study the topological properties of the space L ∞ ( Σ , X ) c ⁎ of all σ-smooth functionals on L ∞ ( Σ , X ) . We prove a form of a generalized Nikodým convergence theorem and characterize relative σ ( L ∞ ( Σ , X ) c ⁎ , L ∞ ( Σ , X ) ) -sequential compactness in L ∞ ( Σ , X ) c ⁎ . We derive a Grothendieck type theorem for L ∞ ( Σ , X ) c ⁎ . The relationships between different classes of linear operators on L ∞ ( Σ , X ) are established.