AbstractThe behavior of sequences of monomer units during the polymer analogous reaction of a homopolymer to a copolymer is investigated with respect to its kinetics and statistics by simulation with a digital computer. Three basic reactions are presupposed with a reacting monomer unit in the chain being surrounded by none, one, or two already reacted units. The change in the probabilities of the monads, diads, triads, tetrads, and pentads with conversion, or with the number of random number events, is recorded in dependence of the probabilities for the three basic reactions. Sequence probabilities and reaction probabilities are discussed in terms of alternation and blockiness of the copolymers. The relation between the kinetics of the sequences obtained by simulation and by an actual polymer analogous reaction is determined. On an actual polymer analogous reaction the ratios of the reaction rate constants are found by fitting computer simulated curves for the triad probabilities to the experimental triad probabilities. The statistics of the sequences is shown to be non‐MARKOVian, in general. Conditional probabilities of different orders are calculated and compared with each other to find the lowest order necessary to calculate longer sequences with reasonable accuracy.