To explore the reliability and superiority of nasoseptal “rescue” flaptechnique in neuroendoscopic transnasal pituitary adenoma resection. Retrospectiveclinical analysis of 113 cases of endoscopic transsphenoid pituitary adenomaresection with the application of nasoseptal “rescue” flap technology. Thereliability and the superiority of the technique were evaluated according to theduration of nasal cavity and sphenoid sinus stage, the incidence of postoperativeanosmia, and cerebrospinal rhinorrhea. The duration of nasal and sphenoid sinusstage was 15–30 min, averaging 24 min. There were 27 cases of intro-operativecerebrospinal fluid leakage, including 24 cases of low-flow cerebrospinal fluid leakand 3 cases of high-flow cerebrospinal fluid leak. Twenty-three cases were convertedfrom nasoseptal “rescue” flap to nasal septum flap. There were 17 cases ofpostoperative olfactory decline or disappearance, 1 case of epistaxis and 1 case ofcerebrospinal rhinorrhea. The application of nasoseptal “rescue” flap technique canproceed sellar floor reconstruction when the diaphragma sellae rupture occurs duringthe operation. There is no obvious increase of the duration of sphenoid sinus andnasal stage and the rate of postoperative olfactory loss. This technique can be usedas a conventional technique for endoscopic transsphenoid pituitary adenomaresection.