Separation Of Nanoparticles Research Articles

Feasibility of high-temperature electrostatic precipitation for the removal of nanoparticles: A case study on iron oxide separation at up to 800 °C

The removal of nanoparticles from hot gas streams is a challenging task. However, there is a huge potential for heat recovery from waste gas incineration, glass furnaces, ceramic, metallurgical, pyrolytic and many other high temperature processes. A prototype application is the separation of nanoparticles formed by condensation in thermal post-combustion processes, in order to achieve efficient heat recovery at high temperatures.This case study evaluates the performance of a high-temperature electrostatic precipitator (HT-ESP) between 400 and 800 °C for both discharge polarities. The tube-type ESP with 150 mm diameter and 1500 mm length is operated isothermally. Two electrode designs are tested by separating flame-generated iron oxide nanoparticles from a flue gas atmosphere. The total number concentration in the raw gas is around 2·107 cm−3 with a temperature-dependent mode diameter of 20–40 nm.Between 400 and 600 °C very high separation efficiencies around 99.998% (number-based) were found with just 1.5 s of residence time and negative polarity, using a wire discharge electrode. In fact, the separation is more efficient than at room temperature which is explained by particle charging with free electrons leading to an exceptionally high particle charge. At 700 °C and 800 °C, thermionic emissions become more relevant for ESP operation. In this range the best separation efficiencies of 99.96% and 99.5% respectively were obtained using a rod discharge electrode operated below the corona onset voltage. The specific input of energy required for 99% separation efficiency at any temperature is less than 250 J/m³.These findings clearly prove that HT-ESPs are a feasible and highly performing alternative for nanoparticle removal from hot gases at up to 800 °C.

Finding the tiny plastic needle in the haystack: how field flow fractionation can help to analyze nanoplastics in food.

While the exact health risks associated with nanoplastics are currently the focus of intense research, there is no doubt that humans are exposed to nanoplastics and that food could be a major source of exposure. Nanoplastics are released from plastic materials and articles used during food production, processing, storage, preparation, and serving. They are also likely to enter the food chain via contaminated water, air, and soil. However, very limited exposure data for risk assessment exists so far due to the lack of suitable analytical methods. Nanoplastic detection in food poses a great analytical challenge due to the complexity of plastics and food matrices as well as the small size and expectedly low concentration of the plastic particles. Multidetector field flow fractionation has emerged as a valuable analytical technique for nanoparticle separation over the last decades, and the first studies using the technique for analyzing nanoplastics in complex matrices are emerging. In combination with online detectors and offline analysis, multidetector field flow fractionation is a powerful platform for advanced characterization of nanoplastics in food by reducing sample complexity, which otherwise hampers the full potential of most analytical techniques. The focus of this article is to present the current state of the art of multidetector field flow fractionation for nanoplastic analysis and to discuss future trends and needs aiming at the analysis of nanoplastics in food.

Separation of TiO2 particles from suspension using indigenous low-cost ceramic microfiltration membrane

The increased use of TiO2 nanoparticles in manufacturing and commercial products has led to environmental contamination and health issues. This study aimed to apply tubular ceramic membrane fabricated using low-cost clays (kaolin, quartz) along with hydroxypropyl methylcellulose binder for the separation of TiO2 nanoparticles from water. The prepared tubular ceramic membrane exhibited excellent water permeability (1.4945 × 10−7 m3/m2s kPa) with an average pore size of 0.178 μm and porosity of 40 %. Cross flow microfiltration experiments using TiO2 nanoparticles suspension were performed by varying the applied pressure (138–414 kPa), cross flow velocity (2.41 × 10−3 - 5.63 × 10−3 m/s), pH (4–11) and feed concentration (0.05–1 wt%). The permeate flux increased linearly with an increase in the pressure as well as cross flow velocity with a maximum permeate flux of 4.24 × 10−5 m3/m2s at 414 kPa, whereas a reduction in permeate flux was observed with increasing feed concentration of TiO2. The membrane displayed 100 % separation efficiency at all the investigated pressures. Furthermore, the membrane fouling mechanism during the microfiltration process was analyzed using resistance-in-series model. Results demonstrated that filtration resistance (Rf) and total resistance (Rt) decreased with increasing cross flow velocity from 2.41 × 10−3 m/s to 5.63 × 10−3 m/s, whereas filtration resistance remained constant at high pressures. The estimated membrane cost is 253 USD/m2 based on raw materials, energy consumption, manpower and equipment cost. These promising results elucidated the suitability of tubular ceramic membrane towards the removal of TiO2 from wastewater.

Multiple amplification-based fluorometric aptasensor for highly sensitive detection of Staphylococcus aureus.

Rapid and accurate detection and identification of Staphylococcus aureus (S. aureus) are of great significance for food safety, environmental monitoring, early clinical diagnosis, and prevention of the spread of drug-resistant bacteria. Herein, we design a fluorometric aptasensor for ultra-sensitive, specific, and rapid detection of S. aureus. The apasensor combines the enrichment and separation of magnetic nanoparticles (MNPs), the biotin-streptavidin conjugation system, and a single S. aureus can release four signaling probes for signal amplification. Aptamer acts as a specific biorecognition element of S. aureus. Four FAM-labeled partially complementary sequences (FAM-pcDNAs) were used as signaling probes. The aptamers were sequential hybridized with the four FAM-pcDNAs to form aptamer&pcDNAs, which were then bound to MNPs via the biotin-streptavidin. When the aptamer specifically recognizes and binds to S. aureus, the FAM-pcDNAs signaling probes are replaced and released into the supernatant. The concentration of S. aureus can be quantified by measuring the fluorescence intensity (λexc/em = 492/520nm) of the replaced signaling probe FAM-pcDNAs. The results show that the proposed fluorometric aptasensor displays good specificity, ultra-high sensitivity (1.23cfu/mL), wide linear range (1 ~ 108cfu/mL), and fast detection speed (~ 1.5h). The recovery test verifies further that the proposed fluorometric aptasensor can detect S. aureus in spiked blood samples. Since aptamers are easy to customize, we believe that fluorometric aptasensors based on multiple amplification have broad prospects in the construction of practical high-performance biosensors for bacterial detection. KEY POINTS: • Multiple amplification-based fluorometric aptasensor for S. aureus is developed • The aptasensor displays high specificity with a LOD of 1.23 CFU/mL • The aptasensor can directly detect S. aureus in spiked blood samples.

In silico simulation and in vitro validation of a continuous microfluidic device for separation of magnetic nanoparticles

Magnetic separation is introduced to separate paramagnetic or superparamagnetic particles and beads from a suspension by implementing an external magnetic field gradient. The strength of this magnetic field declines with rising distance. Batch containers commonly separate nanoparticles from a fluid by imposing an external magnetic field gradient using a permanent magnet. In this system, magnetic particles aggregate the container's wall or bottom, therefore creating a continuous process without any aggregation is desired. In this paper, COMSOL Multiphysics ver. 5.6 (FEM) has been utilized to simulate a continuous microfluidic device with two geometrical designs, linear design (LD) and curved design (CD). The variables are the velocity of the primary fluid and buffer and the channel's width. The optimal designs of both microfluidic devices have been achieved by changing the variables in a specific range without aggregating them to the device's wall. The optimal structures for both designs were built and tested in the laboratory. The optimal velocity was 0.1 mm/s, the optimal channel width was 200 µm for LD, and it was 0.1 mm/s and 400 µm for CD, respectively. The separation percentage in the simulation was 63 %, the spectrophotometry result was 64.08 for LD, and CD showed better results in simulation (85 %) and laboratory experiment (80.24 %). So, this method can be used to optimize nanoparticle separation in microfluidic.

Low-gradient magnetic separation of magnetic nanoparticles under continuous flow: Experimental study, transport mechanism and mathematical modelling.

Low-gradient magnetic separation (LGMS) of magnetic nanoparticles (MNPs) has been proven as one of the techniques with great potential for biomedical and environmental applications. Recently, the underlying principle of particle capture by LGMS, through a process known as magnetophoresis, under the influence of hydrodynamic effect has been widely studied and illustrated. Even though the hydrodynamic effect is very substantial for batch processes, its impact on LGMS operated at continuous flow (CF) condition remained largely unknown. Hence, in this study, the dynamical behaviour of LGMS process operated under CF was being studied. First, the LGMS experiments using poly(sodium 4-styrenesulfonate)-functionalized-MNP as modelled particle system were performed through batchwise (BW) and CF modes at different operating conditions. Here BW operation was used as a comparative study to elucidate the transport mechanism of MNP under the similar environment of CF-LGMS process, and it was found out that the convection induced by magnetophoresis (timescale effective is ∼1200s) is only significant at far-from-magnet region. Hence, it can be deduced that forced convection is more dominant on influencing the transport behaviour of CF-LGMS (with resident time ≤240s). Moreover, we found that the separation efficiency of CF-LGMS process can be boosted by the higher number of magnets, the higher MNP concentration and the lower flowrate of MNP solution. To better illustrate the underlying dynamical behaviour of LGMS process, a mathematical model was developed to predict its kinetic profile and separation efficiency (with average error of ∼2.6% compared to the experimental results).

Rapid construction of ceramic microfiltration membranes with a gradient pore structure using UV-curable alumina suspension

The design and construction of gradient pore structures are effective in the preparation of high-performance ceramic membranes. In this study, ceramic microfiltration membranes with tertiary gradient structures were obtained by combining 3D printing with dip-coating technology based on a UV-curable alumina suspension. Millimeter-scale pyramid-type microporous structures formed by coarse-particle stacking were used in the support, while submicron pore structures formed by the accumulation of fine particles were employed in the membrane layer. The optimized ceramic support had an effective pore size of 1.02 μm and pure water permeance of 1850 L·m−2 h−1·bar−1. After the deposition of the membrane layer, the effective pore size was significantly reduced to 109 nm, while the pure water permeance remained as high as 1050 L·m−2 h−1·bar−1. Additionally, ceramic microfiltration membranes exhibited good performance in the separation of nanoparticles from water suspensions.

Self-adaptive virtual microchannel for continuous enrichment and separation of nanoparticles.

The transport, enrichment, and purification of nanoparticles are fundamental activities in the fields of biology, chemistry, material science, and medicine. Here, we demonstrate an approach for manipulating nanospecimens in which a virtual channel with a diameter that can be spontaneously self-adjusted from dozens to a few micrometers based on the concentration of samples is formed by acoustic waves and streams that are triggered and stabilized by a gigahertz bulk acoustic resonator and microfluidics, respectively. By combining a specially designed arc-shaped resonator and lateral flow, the in situ enrichment, focusing, displacement, and continuous size-based separation of nanoparticles were achieved, with the ability to capture 30-nm polystyrene nanoparticles and continuously focus 150-nm polystyrene nanoparticles. Furthermore, exosome separation was also demonstrated. This technology overcomes the limitation of continuously manipulating particles under 200 nm and has the potential to be useful for a wide range of applications in chemistry, life sciences, and medicine.

Identification and separation of chiral particles by focused circularly polarized vortex beams.

The identification and separation of chiral substances are of importance in the biological, chemical, and pharmaceutical industries. Here, we demonstrate that a focused circularly polarized vortex beam can, in the focal plane, selectively trap and rotate chiral dipolar particles via radial and azimuthal optical forces. The handedness and topological charge of the incident beam have strong influence on identifying and separating behavior: left- and right-handed circular polarizations lead to opposite effects on the particle of trapping and rotating, while the sign of topological charge will change the particle's rotation direction. Such effects are a direct result of the handedness and topological charge manifesting themselves in the directions of the spin angular momentum (SAM) and Poynting vector. The research provides insight into the chiral light-matter interaction and may find potential application in the identification and separation of chiral nanoparticles.

Copper oxide and manganese dioxide nanoparticles on corrugated glass-fiber supporters promote thermocatalytic oxidation of formaldehyde

Low catalytic activity and difficult separation of manganese dioxide nanoparticles limit their application in the removal of volatile organic compounds (VOCs). Herein, copper oxide (CuO) and δ-manganese dioxide (MnO2) catalysts were deposited uniformly on a glass-fiber supporter (GFS) by an in-situ precipitation method. The GFS with the hierarchical pores and great specific surface areas was employed as a catalytic supporter. The MnO2 major catalysts and CuO cocatalysts synergistically promoted the formaldehyde thermocatalytic oxidation, and the removal efficiency arrived at nearly 100% even after cycle tests of 4 times. Thermodynamic calculation results demonstrated that the formaldehyde thermocatalytic oxidation over the CuO–MnO2/GFS was performed via a Mars-van Krevelen mechanism. Namely, the formaldehyde molecules were oxidized by the copper oxide and δ-manganese dioxide, and then the as-produced cuprous oxide and manganese sesquioxide were re-oxidized into copper oxide and manganese dioxide by gas phase oxygen. Notably, copper oxide cocatalysts significantly improved the catalytic activity of the CuO–MnO2/GFS because they not only directly participated in the formaldehyde oxidation but also promoted the oxidation reaction of manganese sesquioxide into manganese oxide. This work revealed the synergistic mechanism of MnO2 major catalysts and CuO cocatalysts in promoting thermocatalytic oxidation of formaldehyde, and provided a promising thermocatalyst for the purification of industrial waste gas.

Photocatalytic Reactor as a Bridge to Link the Commercialization of Photocatalyst in Water and Air Purification

The development of clean and sustainable teleology is vital to treat the critical environmental pollutants. In the last decade, the use of photocatalytic reactors has been widely reported for organic pollutants degradation. From photocatalysis’s application in environmental remediation, the primary technical issue to scientists is always the efficiency. The enhanced photocatalytic efficiency is mainly depended on the materials improvement. However, the design of photoreactors lags behind the development of photocatalysts, which strongly limit the widespread use of photocatalysis technology in environmental remediation. The nanoparticles separation, mass transfer limitation, and photonic efficiency have always been problematic and restrict the high photocatalytic efficiency of photoreactors. To overcome these bottleneck problems, the most popular or newfangled designs of photoreactors employed in air and water treatment has been reviewed. The purpose of this review is to systematize designs and synthesis of innovative TiO2-based photoreactors and provides detailed survey and discussion on the enhanced mechanism of photocatalytic performance in different TiO2-based photoreactors. The most studied photoreactors are the following: packed bed reactor, film reactor and membrane reactor, which have some limitations and advantages. A comprehensive comparison between the different photocatalytic performance of TiO2-based photoreactors is presented. This work aims to summarize the progress of TiO2-based photoreactors and provides useful information for the further research and development of photocatalysis for water and air purification.

Circular Nonuniform Electric Field Gel Electrophoresis for the Separation and Concentration of Nanoparticles.

A circular nonuniform electric field strategy coupled with gel electrophoresis was proposed to control the precise separation and efficient concentration of nano- and microparticles. The circular nonuniform electric field has the feature of exponential increase in the electric field intensity along the radius, working with three functional zones of migration, acceleration, and concentration. The distribution form of electric field lines is regulated in functional zones to control the migration behaviors of particles for separation and concentration by altering the relative position of the ring electrode (outside) and rodlike electrode (inner). The circular nonuniform electric field promotes the target-type and high-precision separation of nanoparticles based on the difference in charge-to-size ratio. The concentration multiple of nanoparticles is also controlled randomly with the alternation of radius, taking advantage of vertical extrusion and concentric converging of the migration path. This work provides a brand new insight into the simultaneous separation and concentration of particles and is promising for developing a versatile tool for the separation and preparation of various samples instead of conventional methods.

SIMULTANEOUS SOLAR PHOTO-DEGRADATION OF PVC-FE-DOPED ZNO-NANOCOMPOSITE FLAKES AND METHYLENE BLUE DYE IN WATER

Simultaneous solar photocatalytic decolorization of Methlene Blue (MB) dye and degradation of polymer nanocomposite film in water has been attempted in the present work. The film immobilized iron (Fe)-doped zinc oxide (ZnO) nanoparticles (NPs) in polyvinyl chloride (PVC) matrix. This reduced the cost of separation of nanoparticles from treated water. Doped NPs were prepared sonochemically using zinc acetylacetonate (0.95 mmol) and ferric acetylacetonate (0.05 mmol) precursors in aqueous ethanol medium. XRD, UV-vis spectroscopy, FESEM and EDX were used for characterizing nanoparticles whereas the film was characterized by SEM. During the process, the film also reduced in weight. Degradation of both the dye and the polymer followed pseudo-first order kinetics. About 28% of the initial concentration of dye and about 5.04% of the initial weight of the PVC-film were decreased in the process after a run time of 3 h 45 minutes.

Ultrasonication followed by enzymatic hydrolysis as a sample pre-treatment for the determination of Ag nanoparticles in edible seaweed by SP-ICP-MS

Seaweed can bioaccumulate nanomaterials that would be transferred to the trophic chain. This work describes the optimization of a method for the separation of silver nanoparticles (AgNPs) from seaweed using an ultrasound-assisted enzymatic hydrolysis method and ulterior determination by single particle inductively coupled plasma mass spectrometry (SP-ICP-MS).The following parameters affecting the isolation of AgNPs were optimized using a Palmaria palmata (red seaweed) sample previously exposed to AgNPs: type of sonication (bath vs. ultrasonic probe), ultrasound amplitude, sonication time, sonication mode (pulsed vs. continuous sonication), concentration of the enzymes mixture (Macerozyme R-10®), and enzymatic hydrolysis time. The stability of AgNPs during extraction was tested by transmission electron microscopy (TEM) and using a standard of 15 nm of polyvinylpyrrolidone (PVP)-coated AgNPs analyzed by SP-ICP-MS. The analytical performance was evaluated with good results. For total Ag determination, the limits of detection and quantification were 2.2 and 7.7 ng g−1, respectively; and for AgNPs determination, the limits of detection in size and number were 14 nm and 4.34 × 107 part g−1, respectively. Besides, the matrix effect, the repeatability and the analytical recovery were also studied. Finally, the method was applied to the analysis of several red (Palmaria palmata) and green (Ulva sp.) seaweed samples.

Trapping plasmonic nanoparticles with MHz electric fields

Dielectrophoresis drives the motion of nanoparticles through the interaction of their induced dipoles with a non-uniform electric field. We experimentally observe rf dielectrophoresis on 100 nm diameter gold nanoparticles in a solution and show that for MHz frequencies, the nanoparticles can reversibly aggregate at electrode gaps. A frequency resonance is observed at which reversible trapping of gold nanoparticle “clouds” occurs in the gap center, producing almost a 1000-fold increase in density. Through accounting for gold cores surrounded by a conducting double layer ion shell, a simple model accounts for this reversibility. This suggests that substantial control over nanoparticle separation is possible, enabling the formation of equilibrium nanoarchitectures in specific locations.

Development of an In Vitro Release Assay for Low-Density Cannabidiol Nanoparticles Prepared by Flash NanoPrecipitation.

Nanoparticle encapsulation is an attractive approach to improve the oral bioavailability of hydrophobic therapeutics. The high specific surface area of nanoparticle formulations, combined with the thermodynamically driven increased solubility of an amorphous drug core, promotes rapid drug dissolution. However, the physicochemical properties of the hydrophobic therapeutic can present obstacles to in vitro characterization of nanoparticle formulations. Namely, drugs with low density and high membrane binding affinity frustrate traditional analytical methods to monitor release kinetics from nanoparticles. In this work, cannabidiol (CBD) was encapsulated into nanoparticles with low polydispersity and high drug loading via Flash NanoPrecipitation (FNP), a scalable self-assembly process. Hydroxypropyl methylcellulose acetate succinate (HPMCAS) and lecithin were employed as amphiphilic particle stabilizers during the FNP process. However, the low density and high membrane binding affinity of the amorphous CBD nanoparticle core prevented the characterization of in vitro release kinetics by conventional methods. Released CBD could not be separated from intact nanoparticles by filtration or centrifugation. To address this challenge, an alternative approach is described to coencapsulate 6 nm hydrophobic Fe3O4 colloids with CBD during FNP. The Fe3O4 colloids were added at 33% by mass (approximately 20% by volume) to increase the density of the nanoparticles, resulting in particles with an average diameter of 160 nm (CBD-lecithin-Fe3O4) or 280 nm (CBD-HPMCAS-Fe3O4). This densification enabled the centrifugal separation of dissolved (released) CBD from unreleased CBD during the in vitro assay while avoiding the losses associated with a filtration step. The resulting nanoparticle formulations provided more rapid and complete in vitro dissolution kinetics than bulk CBD, representing a 6-fold improvement in dissolution compared to crystalline CBD. The coencapsulation of high-density Fe3O4 colloids to enable the separation of nanoparticles from release media is a novel approach to measuring in vitro release kinetics of nanoencapsulated low-density, hydrophobic drug molecules.

Nanoarchitectured Cu based catalysts supported on alginate/glycyl leucine hybrid beads for tainted water treatment

Water pollution reached worrying point due to different dye pollutants which demands an instant solution. One of the best ways to manage water pollutants is their reduction and decolorization to less-toxic and useful compounds. However, reduction process requires an effective, stable, and recyclable catalyst to reduce such pollutants more effectively. Metal nanoparticles (M0) are highly effective catalysts but separation of nanoparticles after reaction is difficult and requires a high-speed centrifugation. If loaded on polymer-beads, they can be easily separated from the reaction-mixture. Hearin, alginate/glycyl leucine (AGL) hybrid-beads were prepared, and copper nanoparticles (Cu0) were grown on it by simple process. M0/AGL bead catalysts were tested toward reducing various toxic compounds. Among all developed composite-beads, the catalytic performance of Cu0/AGL was highest in terms of reduction kinetics. After initial screening for different pollutants, Cu0/AGL was much more effective for MO reduction, thus, all optimized different parameters i.e., catalyst dosage, stability, amount of reducing-agent and recyclability were experimentally determined. The Cu0/AGL showed high-rate constants (kapp) of 0.7566 and 2.9506 min−1 depending on beads content. The reusability of the Cu0/AGL catalysts up to the 7th cycle has been checked. With the use of AGL as support for the Cu nanoparticles, not only the catalytic activity was retained for longer times during reusability, but it helped in their easy separation.

ZnO/ZnS-Polyvinyl Alcohol Hydrogel for Photocatalytic H2-Generation

The separation of nanoparticles from a solution-based photocatalytic reaction is a significant problem in practical applications. To address the issue, we developed a new photocatalyst composite based on ZnO-ZnS heterojunction (ZnOS) embedded in polyvinyl alcohol (PVA) hydrogel, which showed satisfactory results for photocatalyst recycling. PVA-ZnOS composite hydrogel was fabricated by freezing-induced gelation, which enabled the encapsulation of ZnOS nanoparticles into polymeric matrices. PVA hydrogel served as a promising candidate in photocatalytic applications due to its excellent properties such as high transparency, porosity, hydrophilicity, and stability under ultraviolet (UV) light. PVA-ZnOS hydrogel showed worthy activity in H2 generation from Na2S/Na2SO3 aqueous solution under UV radiation with a production rate of 18.8 µmol·h−1. PVA-ZnOS composite hydrogel is a separation-free photocatalyst, which is prospective in a solution-based photocatalytic reactor.

High-Resolution Separation of Nanoparticles Using a Negative Magnetophoretic Microfluidic System.

The separation and purification of a sample of interest is essential for subsequent detection and analysis procedures, but there is a lack of effective separation methods with which to purify nano-sized particles from the sample media. In this paper, a microfluidic system based on negative magnetophoresis is presented for the high-resolution separation of nanoparticles. The system includes on-chip magnetic pole arrays and permalloys that symmetrically distribute on both sides of the separation channel and four permanent magnets that provide strong magnetic fields. The microfluidic system can separate 200 nm particles with a high purity from the mixture (1000 nm and 200 nm particles) due to a magnetic field gradient as high as 10,000 T/m being generated inside the separation channel, which can provide a negative magnetophoretic force of up to 10 pN to the 1000 nm particle. The overall recovery rate of the particles reaches 99%, the recovery rate of 200 nm particles is 84.2%, and the purity reaches 98.2%. Compared with the existing negative magnetophoretic separation methods, our system not only exhibits high resolution on particle sizes (800 nm), but also improves the sample processing throughput, which reaches 2.5 μL/min. The microfluidic system is expected to provide a new solution for the high-purity separation of nanoparticles, as well as nanobiological samples.

Permeability and selectivity analysis for affinity‐based nanoparticle separation through nanochannels

AbstractWhereas the separation by surface affinity represents an advanced technique for the separation of nanoparticles with distinct surface properties, how the interaction of particles with nanochannel impacts the separation performance is less understood. Herein, the dynamical density functional theory is employed to study the separation of two types of similar‐sized particles with different surface affinities within nanochannels. We show that a proper design of the channel inner‐surface, which attracts one type of particles while repelling the other, can promote the permeability and selectivity of particles. Meanwhile, the trade‐off relations between permeability and selectivity are found and analyzed in nanochannels of different sizes. Based on dynamical density functional theory calculations, an extended model relating permeability to the equilibrium partition coefficient is proposed to analyze the permeability and selectivity, which displays good predictions of the transport of charged particles in comparison with experimental results. This work provides helpful insights for designing an efficient affinity‐based separation of nanoparticles process through nanochannels.