Separate Units Research Articles

Leukocyte formula of the Walser’s Viper (Vipera walser)

Vipera walser is a recently assessed species of North-Western Italian Alps, that has been regarded as an isolated population of V. berus until 2016, when it has been identified as a separate taxonomical unit according to molecular markers. Due to its restricted and fragmented range and the potential threat of climate change in mountain systems, it complies with the IUCN criteria to be classified as EN. In order to investigate, in part, the health status of this taxon, we have performed blood smears to describe whether a haematological parameter such as leukocytes is consistent with those of more widespread viperids of the Italian peninsula. Overall, we sampled 20 Walser’s Vipers across the species range and characterised leukocyte formula. We found that lymphocytes were the most common (~ 70% of total leukocytes). Eosinophils and heterophils were less abundant, while neutrophils and monocytes are the least represented. Our data is in accordance with that of other European viperids

Genetic Polymorphism and Differentiation of Populations of Sterlet Acipenser ruthenus (Acipenseridae) in the Lower Irtysh and Middle Ob Basins

The article presents data on polymorphism of intermicrosatellite sequences in the sterlet Acipenser ruthenus of the lower reaches of the Irtysh River and the middle reaches of the Ob River. We assessed intra- and interpopulation variability and genetic differentiation of A. ruthenus and revealed a high ISSR polymorphism in the species from the central part of the Ob-Irtysh basin. The proportion of polymorphic amplicons was 0.966, genetic diversity was 0.355, and the average number of alleles per locus was 1.97. The highest polymorphism was typical for the sterlet from the Tobol River at the confluence with the Irtysh River. Genetic differentiation between the sterlet groups of the Irtysh and Ob rivers is well pronounced, the interpopulation component accounts for 42% of variability (Gst = 0.42), gene flow is limited (Nm = 0.67). The sterlet groups inhabiting the Lower Irtysh from the mouth of the Tobol River to the mouth of the Konda River do not differ genetically and form one population (Gst = 0.08–0.12, Nm = 3.76–5.55). The sterlet from the Irtysh River within the Vagay region is genetically different from the other Irtysh samples (Gst = 0.22, Nm = 1.68) and belongs to a different population group. The differentiation between samples of sterlet from the Ob basin is higher than between samples from the Irtysh basin. Groups of sterlet from the Ob River and the Yuganskaya Ob canal are genetically different (Gst = 0.30, Nm = 1.19) and form various subpopulations. Spawning migrations, as well as confinement to wintering pits, play a decisive role in the formation of the sterlet population structure in the studied part of the distribution area. The identified sterlet population groups should be considered as separate units of environmental and economic management.

Real-world outcomes following ibrutinib dose reduction in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma

This study used real-world data from three separate United States (US) databases to evaluate dosing patterns and time to next treatment (TTNT) following the first-incident adverse event (AE) in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) treated with first-line ibrutinib with and without dose reduction (DR). Median TTNT or death in patients with and without a DR following an AE in each database was as follows: Optum Clinformatics Data Mart (CDM): 59.5 and 30.6 months; ConcertAI: 27.1 and 18.0 months; and Medicare Fee-for-Service (FFS): 49.8 and 22.0 months, respectively. Median TTNT or death in patients with cardiac AEs, with and without a DR, was: Optum CDM: 44.4 and 22.9 months; ConcertAI: 29.9 and 18.3 months; and Medicare FFS: 49.6 and 14.0 months, respectively. Ibrutinib DR was associated with fewer outpatient visits and lower CLL/SLL-related medical costs. These findings suggest that utilizing ibrutinib DR may effectively manage tolerability without compromising clinical efficacy.

QLTI-19. PEDIATRIC NEURO-ONCOLOGISTS NAVIGATING AN ADULT WORLD: A TALE OF TWO CENTERS

Abstract BACKGROUND Adolescent and Young Adult Neuro-Oncology(AYA-NO) patients are a distinct cohort with an overlap of tumors found in childhood and adulthood. For adult patients with pediatric-type Central Nervous System tumors, optimal work-flow to manage these patients is unclear. METHODS We examine the work-flow of pediatric neuro-oncologists starting AYA-NO clinics within two high volume adult institutions: the University of Miami(Florida, USA) and the Princess Margaret Cancer Centre(Toronto, Canada). RESULTS Over 18 months, the AYA-NO clinics managed 167 patients total with several key differences emerging in both institutions between the pediatric and adult work-flows. Adult providers commonly have neurology backgrounds, while pediatric providers mostly have hematology/oncology backgrounds. In pediatrics, providers typically meet the patient inpatient before pathology results, adult providers meet their patients in outpatient settings once histopathology results are available. Outpatient management in pediatric oncology centers typically includes labs, infusion centers, provider rooms, and social workers in one area while adults, due to the larger volume, have these services on separate units. Chemotherapy related differences included the primary provider for inpatient admissions and the emphasis of adult institutions on outpatient administration when feasible. Psychosocial factors such as the variety of caregivers, increased opportunity for patient autonomy in decision-making, and the increased fragmentation in care magnifies the importance of providers forming a strong rapport with AYA-NO patients. End of life care is vastly different including the inability for adult patients to receive palliative treatment in hospice care and the availability medically-assisted death. CONCLUSION Pediatric neuro-oncologists building AYA-NO workflows within adult settings can provide unique expertise for AYA-NO patients with pediatric-type tumors. Growing AYA-NO clinics can benefit from allocating AYA CNS specific resources such as chemotherapy/targeted therapy provider education, a dedicated hospital/clinic space, chemotherapy nursing, a care coordinator, and a social worker with experience treating this patient population.

Efficient Electrosynthesis of Valuable para‐Benzoquinone from Aqueous Phenol on NiRu Hybrid Catalysts

AbstractElectrocatalytic oxidation of aqueous phenol to para‐benzoquinone (p‐BQ) offers a sustainable approach for both pollutant abatement and value‐added chemicals production. However, achieving high phenol conversion and p‐BQ yield under neutral conditions remains challenging. Herein, we report a Ni(OH)2‐supported Ru nanoparticles (NiRu) hybrid electrocatalyst, which exhibits a superior phenol conversion of 96.5 % and an excellent p‐BQ yield of 83.4 % at pH 7.0, significantly outperforming previously reported electrocatalysts. This exceptional performance benefits from the triple synergistic modulation of the NiRu catalyst, including enhanced phenol adsorption, increased p‐BQ desorption, and suppressed oxygen evolution. By coupling a flow electrolyzer with an extraction‐distillation separation unit, the simultaneous phenol removal and p‐BQ recovery are realized. Additionally, the developed electrocatalytic system with the NiRu/C anode displays good stability, favorable energy consumption, and reduced greenhouse gas emissions for phenol‐containing wastewater treatment, demonstrating its potential for practical applications. This work offers a promising strategy for achieving low‐carbon emissions in phenol wastewater treatment.

Sankcje za wyłączenie gruntów leśnych z produkcji w świetle doktryny i orzecznictwa – głos w dyskusji

The Act of 3 February 1995 on the protection of agricultural and forest land in Article 28 provides for sanctions for the exclusion of agricultural and forest land from production contrary to the provisions of the Act (paragraph 1) or without a decision authorising the exclusion in the case of land which has been designated in the local spatial development plan for non-agricultural or non-forest purposes (paragraph 2). In the first case, the authority shall set a fee of double the amount due, and in the second case, the authority shall issue a ‘legalisation’ decision based on Article 12 and increase the amount due by 10%. The provision of Article 12(6) of the Law on the Protection of Agricultural and Forestry Land also provides for the possibility of reducing the amount due by the value of the land in accordance with the market price. The possibility of applying Article 12(6) in the case indicated in Article 28(2) of the Agricultural and Forest Land Protection Act is problematic. It should be emphasised that the content of the provisions in question has not changed since 1995. They were treated as two different legal situations and did not give rise to any doubts in practice or jurisprudence. It was accepted that the authority obliged to issue a legalisation decision had the right to apply Article 12(6). The position of administrative courts has been different for several years now, according to which the provisions of Article 28(1) and (2) should be treated jointly, as they both provide for sanctions, although they constitute separate editorial units. In the doctrine approval is also found for the new views of the judicature accepting that in the case indicated in Article 28(2) it is not possible to apply a reduction in the amount due by the value of the land. The practice presented by the regional directorates of the State Forests, on the other hand, is very diverse. The problem that has arisen requires that the various positions be voiced and evaluated.

Current State of Professionalism Curriculum in Oral Health Education.

The aim of this study was to systematically review the relevant literature on teaching professionalism in dental curricula and report the relevant data from a survey of members of the Association for Dental Education in Europe (ADEE) on the topic. We conducted a systematic review of the literature and a cross-sectional study using an online questionnaire regarding teaching and assessment of professionalism in dental schools, members of the ADEE. The literature review identified 33 articles related to professionalism in dental curricula. The survey sent to the membership of the Association for Dental Education in Europe yielded responses from 27 European dental schools and four schools outside Europe. Various study designs were identified in the review, and the main themes discussed included teaching/pedagogy, ethics/humanities, core domains and assessment of professionalism. Twenty schools reported having specific courses dedicated to professionalism, while the format varied, including entire modules, separate learning outcomes or unit structures. Ethics, communication, law/legal framework/deontology, teamworking and management/leadership were among the common topics taught under the banner of professionalism. Many schools reported increases or no changes in hours, staffing, themes/topics covered and weight in the curriculum for professionalism over the last decade. The paper provides valuable insights into the current state of professionalism education in dental curricula and offers directions for enhancing its effectiveness and relevance in preparing future dental professionals. Collaborative efforts among dental educators and institutions can contribute to the continuous improvement of professionalism education and practice in dentistry.

Complex Words as Shortest Paths in the Network of Lexical Knowledge.

Lexical models diverge on the question of how to represent complex words. Under the morpheme-based approach, each morpheme is treated as a separate unit, while under the word-based approach, morphological structure is derived from complex words. In this paper, we propose a new computational model of morphology that is based on graph theory and is intended to elaborate the word-based network approach. Specifically, we use a key concept of network science, the notion of shortest path, to investigate how complex words are learned, stored, and processed. The notion of shortest path refers to the task of finding the shortest or most optimal path connecting two non-adjacent nodes in a network. Building on this notion, the current study shows (i) that new complex words can be segmented into morphemesthrough the shortest path analysis; (ii) that attested English words tend to represent the shortest paths in the morphological network; and (iii) that novel (unattested) words receive higher acceptability ratings in experiments when they are formed along established optimal paths. The model's performance is tested in two experiments with human participants as well as against the behavioral data from the English Lexicon Project. We interpret our empirical results from the perspective of a usage-based model of grammar and argue that network science provides a powerful tool for analyzing language structure.

Totally conjugated and coplanar covalent organic frameworks as photocatalysts for water purification: Reduction of Cr (VI) while oxidizing water borne organic pollutants

Covalent organic frameworks (COFs) have emerged as photocatalytic materials with bandgaps in the visible region. Imine-based COFs, which have been extensively explored, often suffer from limited stability and poor conjugation, hindering their photocatalytic activities. The chemical and hydrolytic stability and the photocatalytic performance of COFs is drastically enhanced by constructing 2D COFs that are fully conjugated in the x,y plane, that have alternating donor–acceptor (D-A) units for better charge separation and that have enhanced conjugation in the z-axis by p-orbital overlap by using highly planar building blocks. In this study, we introduce three highly crystalline sp2 COFs that are able to photocatalyticlly reduce highly toxic Cr (VI) species to much less toxic and easily removable Cr (III) residues, while simultaneously oxidizing water borne organic pollutants. One of them, the TEB-COF, with the integration of the acetylene group, exhibited excellent photocatalytic activity due to its superior planarity and extended conjugation. TEB-COF is able to completely remove the model dye Rhodamine B and Cr (VI) (10 mg/L) in less than 30 min. This research provides valuable insights into the development of recyclable metal-free photocatalysts for wastewater treatment.

Continuous bioethanol production from glucose-rich hydrolysate derived from wheat straw using a unique fed-batch cultivation method in a bioreactor

The present study provides solutions to the bioethanol industry’s main issues of the absence of production of maximum fermentable sugars from lignocellulosic biomass, the unsuitability of a single microorganism to convert the fermentable sugars (xylose and glucose) together to bioethanol, and the unavailability of fermentation technique to run the process unlimitedly with consistent yield and productivity. A novel fractional acid hydrolysis technology was demonstrated in this study, which produced more than 90% (w/w) of available glucose in wheat straw as glucose-rich hydrolysate (GRH). This hydrolysate was then made acid-free using a membrane-based acid separation unit to reuse the separated acid to make the hydrolysis process environmentally safe and chemically inexpensive. Thereafter, this acid-free GRH was fermented to bioethanol using a unique constant volume fed-batch fermentation technique under an optimum glucose-feeding strategy. Remarkably, this fermentation technique yielded optimal average bioethanol productivity (g/Lh), yield (g/g), and titer (g/L) of 7.147±0.533, 0.508±0.002, and 58.835±0.766; 5.722±0.529, 0.501±0.006, and 33.748±0.322, respectively, with more than 99% glucose utilization during ten fed-batch cycles of synthetic and GRH glucose. Notably, the high production of GRH from lignocellulosic biomass, acid separation and reuse, and continuous and consistent bioethanol production sets this study apart as a pioneering endeavor. Furthermore, the bioethanol profit of USD 0.019/kg biomass from the second batch onwards at a bioethanol selling price of USD 0.745/L suggests the feasibility of the current study for industrial-scale bioethanol production from lignocellulosic biomass.

Rethinking the Anthropocene: Not a time-transgressive event but a sudden rupture on the geologic time scale

The recent decision by the International Commission on Stratigraphy to reject the Anthropocene as an Epoch has reignited the debate on its definition. Some scholars have argued for interpreting the Anthropocene as an Event with no specific point of onset, but this argument has its shortcomings, including the fact that the term event has multiple connotations. This Viewpoint adds important insight to the ongoing debate by positing that (i) deliberations on the Anthropocene’s definition should not be confined to geological and historical viewpoints and must include ecological insights, and (ii) there is widespread evidence of anthropogenic reconfiguration of the planetary biosphere which translates to an accelerating sixth mass extinction as well as a conspicuous rise in the Human Appropriation of Net Primary Productivity (HANPP) at an unprecedented rate during the past few decades. When considered together with rapid anthropogenic climate change, these trends mark a major departure from previous trends on the geologic timescale, and they clearly show that the planetary biosphere has recently undergone a sudden and abrupt shift into a novel state, which cannot be adequately described by a temporally diffuse, gradual event; and must be conceptualized as a rupture—a geologically sudden major departure from prevalent trends; which in turn justifies the conceptualization of the Anthropocene as a separate chronostratigraphic unit. Understanding the catastrophic nature of the recent anthropogenic impact on the planetary biosphere is crucial for interpreting the Anthropocene and geologists must be cautious not to dilute its magnitude.

Necrotizing enterocolitis following spontaneous intestinal perforation in very low birth weight neonates.

Necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP) are severe gastrointestinal complications of prematurity. The clinical presentation and treatment of NEC and SIP (peritoneal drain vs laparotomy) can overlap; however, the pathogenesis is distinct. Therefore, a patient initially treated for SIP can subsequently develop NEC. This phenomenon has only been described in case reports, and no risk factor evaluation exists. We evaluate clinical characteristics, risk factors, and outcomes of patients treated for a distinct episode of NEC after SIP. We performed a retrospective review of very low birth weight (<1500 g) neonates who presented with pneumoperitoneum between 07/2004 and 09/2022. Data was obtained from two separate neonatal intensive care units that were part of the same institution. Patients with an initial preoperative, intraoperative, or pathological diagnosis of NEC were excluded. Patients with an intraoperative diagnosis of SIP or preoperative diagnosis of SIP successfully treated with a peritoneal drain (PD) were evaluated. Patients subsequently treated (medically or surgically) for NEC after SIP were then compared to SIP-alone patients. Clinical characteristics included demographics, gestational age (GA), birth weight (BW), perinatal risk factors (chorioamnionitis, steroids, indomethacin), postoperative feeding regimen, and length of stay (LOS) were compared. Of the 278 patients included, 31 (11.2%) patients had NEC after SIP. There was no difference in GA (25 weeks vs 25 weeks, p = 0.933) or BW (760 g vs 735 g, p = 0.370) between NEC after SIP vs SIP alone cohorts, respectively. Twenty (64%) of NEC after-SIP patients were previously treated with LP. NEC after SIP occurred with a median onset of 56 days. Pneumatosis was the most frequent (81%) presenting symptom and 12 (39%) patients had hematochezia. Four (12.9%) patients required LP for NEC and all had NEC intraoperatively and on pathology. A majority (77.4%) of patients were on breast milk (BM) at time of NEC diagnosis. NEC after SIP patients had lower maternal age at delivery (29.0 vs 25.0, p = 0.055) and the incidence of NEC after LP (primary or failed drain) was higher than PD alone (16.7% vs 6.2%, p = 0.007). NEC after SIP patients had longer LOS (135 vs 81, p < 0.001). We report an 11.2% incidence of NEC at a median of 56 days following successful treatment of SIP, resulting in increased LOS. SIP patients are a high-risk cohort and protocols to prevent this phenomenon should be investigated.

Thermodynamic evaluation of a Ca-Cu looping post-combustion CO2 capture system integrated with thermochemical recuperation based on steam methane reforming

The calcium looping integrated with the chemical looping combustion (CaL-CLC) process is an efficient and cost-effective CO2 capture technology that avoids the energy-intensive air separation unit in the calcium looping (CaL) process. However, in these CaL-CLC and CaL system integration schemes, the carbonation heat is utilized for steam generation, resulting a significant temperature difference and considerable irreversible loss. To prevent temperature mismatch, this paper proposes a novel Ca-Cu looping post-combustion CO2 capture method with thermochemical recuperation based on steam methane reforming. Additionally, a novel system integrated with turbine exhaust heat recovery is introduced to effectively reduce carbon emissions from flue gas. Results show that the proposed system has superior performance compared to the reference system based on the Ca-Cu looping method. The specific primary energy consumption for CO2 avoidance decreased from 2.40 MJLHV/kg CO2 in the reference system to 2.02 MJLHV/kg CO2. Exergy analysis indicates that a total of 3.0 % reduction in exergy destruction can be achieved in chemical reaction processes and heat recovery processes, contributing to the superior performance of the proposed system. Furthermore, the effects of key operating parameters indicate that cascaded turbine exhaust recovery is essential for improving the thermodynamic efficiency of the proposed system. Overall, recovering the mid-temperature carbonation heat via thermochemical regeneration and integrating with exhaust heat recovery contribute to reducing SPECCA, thus providing a promising low-energy-consumption alternative for CO2 capture.

Novel heavy fuel oil based IGCC polygeneration system based on integration with ejector cooling and heat recovery of the solid oxide fuel cell in adsorption desalination

An innovative polygeneration system based on the gasification of heavy fuel oil including Orimulsion, Mazut, and Asphaltene has been proposed. In this system, electricity, hot water, cooling, hydrogen, fresh water, and nitrogen are produced in an innovative way to improve the system. In this regard, the integration of an Integrated Gasification Combined Cycle-Organic Rankine Cycle- Ejectero Refrigeration Cycle-Solid Oxide Fuel Cell-Adsorbation Deselination-Polyer Electron Electrolyzer has been proposed. The proposed system was investigated from the points of view of energy, exergy, exergoeconomic, and exergoenvironmental. In addition, to model the air separation unit, machine learning techniques have been employed.The results show that if Mazut is used as a gasification material, the system will have 36.81 %, 33.3 %, and 66.22 mPts/kWh in terms of polygeneration energy efficiency, polygeneration exergy efficiency and Levelized environmental impact of electricity, respectively and if Orimulsion is used, the Levelized cost of electricity value will be 33.32$/MWh which are the best performance in three fuel. Nitrogen production in this system is 35.08 kg/s, and hydrogen production is 0.0051 kg/s. The value of specific daily water production in the AD unit is 8.40 m3watertonofsilicagelper day, and the flow of hot water produced is 7.37 kg/s.

Efficient Electrosynthesis of Valuable para-Benzoquinone from Aqueous Phenol on NiRu Hybrid Catalysts.

Electrocatalytic oxidation of aqueous phenol to para-benzoquinone (p-BQ) offers a sustainable approach for both pollutant abatement and value-added chemicals production. However, achieving high phenol conversion and p-BQ yield under neutral conditions remains challenging. Herein, we report a Ni(OH)2-supported Ru nanoparticles (NiRu) hybrid electrocatalyst, which exhibits a superior phenol conversion of 96.5% and an excellent p-BQ yield of 83.4% at pH 7.0, significantly outperforming previously reported electrocatalysts. This exceptional performance benefits from the triple synergistic modulation of the NiRu catalyst, including enhanced phenol adsorption, increased p-BQ desorption, and suppressed oxygen evolution. By coupling a flow electrolyzer with an extraction-distillation separation unit, the simultaneous phenol removal and p-BQ recovery are realized. Additionally, the developed electrocatalytic system with the NiRu/C anode displays good stability, favorable energy consumption, and reduced greenhouse gas emissions for phenol-containing wastewater treatment, demonstrating its potential for practical applications. This work offers a promising strategy for achieving low-carbon emissions in phenol wastewater treatment.

Synergizing autothermal reforming hydrogen production and carbon dioxide electrolysis: Enhancing the competitiveness of blue hydrogen in sustainable energy systems

With the global energy paradigm shifting towards renewable and sustainable systems, hydrogen is increasingly recognized as a promising energy carrier. In this transition, blue hydrogen is often considered a bridge solution to green hydrogen due to its economic vulnerability to carbon costs and environmental regulations related to life-cycle emissions. To expand the role of blue hydrogen, it is essential to enhance hydrogen yield, reduce production costs, and minimize greenhouse gas emissions during the production phase. This study proposes an integrated process for blue hydrogen production and CO2 electrolysis to enhance the competitiveness of blue hydrogen in sustainable energy systems. The focus of this study was to integrate autothermal reforming hydrogen production with solid oxide CO2 electrolysis and to determine the optimal configuration and operating conditions of the integrated process. The proposed process demonstrated superior performance in terms of energy efficiency, production cost, and environmental impact compared with conventional blue hydrogen production. Furthermore, considering the intermittency of renewable electricity and the uncertainties in CO2 electrolysis technology, the industrial feasibility of the proposed process was validated. The integration of autothermal reforming blue hydrogen production and CO2 electrolysis has four clear advantages: (i) the costly air separation and carbon capture units, which pose significant financial burdens in autothermal reforming blue hydrogen production, can be eliminated; (ii) the downstream separation, which is indispensable in a standalone CO2 electrolysis system, can be removed; (iii) utilization pathways for captured CO2 from blue hydrogen production have been proposed; and (iv) guidelines have been provided for the industrial utilization of CO2 electrolysis.

Unaccompanied minors: agency and rights

This paper attempts to exam the causes of minors’ migration, to focus on the subject of unaccompanied minors’ agency and to highlight its importance. In order to do so, a link between children’s agency and their rights will be presented. Trying to achieve the above aim, the above topic will be analyzed into separated units and all the data has been based both on relevant literature and on empirical data that have occurred after many years of work in the refugee field, specifically with unaccompanied and separated children.

Triazenolysis of alkenes as an aza version of ozonolysis.

Alkenes are broadly used in synthetic applications, thanks to their abundance and versatility. Ozonolysis is one of the most canonical transformations that converts alkenes into molecules bearing carbon-oxygen motifs via C=C bond cleavage. Despite its extensive use in both industrial and laboratory settings, the aza version-cleavage of alkenes to form carbon-nitrogen bonds-remains elusive. Here we report the conversion of alkenes into valuable amines via complete C=C bond disconnection. This process, which we have termed 'triazenolysis', is initiated by a (3 + 2) cycloaddition of triazadienium cation to an alkene. The triazolinium salt formed accepts hydride from borohydride anion and spontaneously decomposes to create new C-N motifs upon further reduction. The developed reaction is applicable to a broad range of cyclic alkenes to produce diamines, while various acyclic C=C bonds may be broken to generate two separate amine units. Computational analysis provides insights into the mechanism, including identification of the key step and elucidating the significance of Lewis acid catalysis.

Automated Optimization of a Multistep, Multiphase Continuous Flow Process for Pharmaceutical Synthesis.

Flow synthesis is becoming increasingly relevant as a sustainable and safe alternative to traditional batch processes, as reaction conditions that are not usually achievable in batch chemistry can be exploited (for example, higher temperatures and pressures). Telescoped continuous reactions have the potential to reduce waste by decreasing the number of separate unit operations (e.g., crystallization, filtration, washing, and drying), increase safety due to limiting operator interaction with potentially harmful materials that can be reacted in subsequent steps, minimize supply chain disruption, and reduce the need to store large inventories of intermediates as they can be synthesized on demand. Optimization of these flow processes leads to further efficiency when exploring new reactions, as with a higher yield comes higher purity, reduced waste, and a greener synthesis. This project explored a two-step process consisting of a three-phase heterogeneously catalyzed hydrogenation followed by a homogeneous amidation reaction. The steps were optimized individually and as a multistep telescoped process for yield using remote automated control via a Bayesian optimization algorithm and HPLC analysis to assess the performance of a reaction for a given set of experimental conditions. 2-MeTHF was selected as a green solvent throughout the process, and the heterogeneous step provided good atom economy due to the use of pure hydrogen gas as a reagent. This research highlights the benefits of using multistage automated optimization in the development of pharmaceutical syntheses. The combination of telescoping and optimization with automation allows for swift investigation of synthetic processes in a minimum number of experiments, leading to a reduction in the number of experiments performed and a large reduction in process mass intensity values.

Techno-economic investigation of an entirely solar-powered hybrid HDH/RO desalination plant for moderate water demand under various operating conditions

The study presented a scalable, entirely solar-powered hybrid desalination system suitable for moderate demand and valid for various water salinities. The system merged two desalination techniques: HDH (humidification-dehumidification) and RO (reverse osmosis) units. The required power for all components was obtained from a photovoltaic system. The experiments were conducted to evaluate the separate units and hybrid system performances under different conditions, including various sprayed hot water (to the HDH) temperatures, RO feed water temperatures, air velocities, and water salinities. Based on the recorded data, the techno-economic analyses were conducted to assess the gain output ratio (GOR), recovery ratio (RR), specific energy consumption (SEC), the total amount of dissolved solids (TDS), and product cost. As a result, the RO unit's productivity increased almost linearly with feed temperature, showing a maximum hourly yield of 60 L/m2. In contrast, HDH productivity showed exponential growth with feed temperature, achieving a maximum hourly yield of 18 L/m2. The SEC of the RO unit decreased from 1.1 kWh/m³ to 0.63 kWh/m³ when using the rejected HDH's hot brine. The hybrid system's accumulated productivity reached 535 L/m2, significantly higher than the standalone HDH (58.5 L/m2) and standalone RO (368 L/m2). Additionally, the hybrid system demonstrated substantial improvements in GOR and RR, with daily values of 11.15 and 55.73%, respectively. Economically, the distillate water cost was significantly lower, at 0.63 $/m³ for the HDH/RO system compared to 3.51 $/m³ for the standalone HDH.