Separate Files Research Articles

Metabolites of Rusuvastatin Inhibit Oxidation of both Low-Density Lipoproteins and Very Low-Density Lipoproteins

Coronary Artery Disease is caused by plaque buildup in the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. Plaque is made up of deposits of cholesterol and other substances in the artery. Plaque buildup causes the inside of the arteries to narrow over time, which could partially or totally block the blood flow. This process is called atherosclerosis. Coronary artery disease (CAD), when get worst, it is known as coronary artery syndrome (CAS). There are many allopathic medications which can stop, even at starting points of the disease (CAD). Hypolipidemic drugs like statins, fibrates, resins and niacin are well known agents used for prevention of CAD. There are ethnic-based medicinal herbs which can be used to treat or prevent CAD with narrow to moderate range of statistical significance. We compared Rosuvastatin 10 mg with Indian dates (Jujubes) as hypolipidemic agents. This research was conducted at Ghurki Trust Teaching Hospital, jalo park, Lahore, Pakistan. Duration of study was two months. Twenty to seventy years old 60 hyperlipidemic patients of both gender were included in research work with written consent. We divided these patients in two equal groups. Group-I was advised to take Tablet Rosuvastatin 10 mg, twice daily for two months. Group-II was advised to take 500 grams Indian dates for two months. Their baseline parameters like LDL-cholesterol, HDL-cholesterol, systolic/diastolic blood pressure was determined in the hospital laboratory. Separate file was maintained for their name, age, sex, occupation, and address. After two months therapy we compiled data related to tested parameters. Paired t-test was applied to compare changes in all parameters. Their mean values with ± SD before and after treatment were compared and analyzed statistically. It was observed that Rosuvastatin significantly decreased systolic/diastolic blood pressure, LDL-cholesterol, and increased HDL-cholesterol in 27 hyperlipidemic/hypertensive patients. Indian dates used in 30 hyperlipidemic patients significantly decreased systolic blood pressure, and LDL-cholesterol, but insignificant changes were seen in diastolic blood pressure, and HDL-cholesterol. We concluded from the research work that Rosuvastatin is potent hypolipidemic and hypotensive medicine as compared to indian dates.

Outcome of Low Dose of Tamoxifen for Ocular Manifestations in Breast Cancer Patients

Background: Tamoxifen, a non-steroidal triphenylethylene estrogen antagonist, serves as a crucial therapy, both alone and in conjunction with other treatments, for disseminated breast carcinomas due to its proven efficacy and minimal adverse effects in oncology. Despite its extensive use, ocular toxicity reports linked to tamoxifen remain relatively scarce in available literature. Given the limited studies in the Bangladeshi context, this investigation aims to explore ocular manifestations in breast cancer patients undergoing prolonged low-dose tamoxifen therapy for over two years. Methods: This longitudinal study was conducted at Dhaka Medical College Hospital between October 2019 and July 2020, involving 45 patients undergoing low-dose tamoxifen treatment for more than two years post-surgical intervention for breast carcinoma. Detailed patient histories were obtained, and thorough ophthalmic examinations were performed for each participant. Data were meticulously recorded in separate case files and analyzed using SPSS 22 to ensure accuracy and reliability. Observations and Results: The average age of the patients was 51.16 (±8.82) years, and 11.10% of the respondents exhibited ocular manifestations. These manifestations primarily comprised cataracts (6.70%), retinitis (2.20%), and optic neuritis (2.20%). Regarding eye-related conditions, cataracts are evident in patients 01, 02, and 03, while retinitis is observed in patients 04 and 05. Optic neuritis is specifically noted in patient 05. The data highlights occurrences of these conditions in relation to the duration of Tamoxifen treatment and the patients' ages, potentially suggesting associations worthy of further exploration regarding the impact of Tamoxifen on eye health in this demographic. Conclusion: This study revealed that approximately one-tenth of the patient cohort undergoing tamoxifen therapy for over two years experienced ocular manifestations. However, further in-depth investigations are strongly ...

Effect of different generated weather climate data file on building energy consumption in different climates of Iran

Accurate estimation of building energy consumption is critical, and it can usually be calculated using simulation software like Energy Plus. The input weather data for software is typically a typical or reference year as a standard weather file, such as TMY2. To best estimate building energy consumption, TMY2 data must be generated intelligently. In the present study, first, several TMY2 data files have been generated from different periods (5–21 years) of available measured weather data (9 separate files). Available measured weather data is for 1998 to 2019. Also, a TMY2 file has been generated from the long-term average for the total period (1998–2019), and two TMY2 files have been generated using the CCWeatherGen software for 2020 and 2050. In the next step, the calculated building energy consumption from those files for an educational building will be compared using Energy Plus software. The primary purpose of this study is to investigate the impact of different generated TMY2 (from different weather data periods) on energy consumption and determine the best period to generate TMY2 files from the available period of 5 to 21 years for the capital of Iran (Tehran), which has a semi-arid climate, and Tabriz, which has a cold and mountainous climate. These cities have different climates. Results show that for Tehran, building heating energy consumption changes by about 10% from other generated TMY2 files (one file generated from 2009 to 2019 and another generated from the 2007 to 2019 period). The result shows that generating TMY2 files from different weather data periods affects building energy consumption. So, a suitable strategy for generating TMY2 files is necessary. As a new strategy, the present study proposes that TMY2 files should be generated based on building cooling and heating energy from recent years. Also, because climate change is an important parameter, a TMY2 file should be generated from recent years’ weather data to accurately predict building energy consumption.

Factors Affecting Medical Records Management in Karakah Health Center Padang

Medical records are an administration system that starts from recording while the patient is receiving medical services, followed by handling medical record files which includes organizing storage and removing files from storage to serve requests/borrowing from patients or for other purposes. All health service facilities are required to maintain medical records, including community health centers (Puskesmas). Based on initial data collection observations, it was found that medical record management was still carried out manually, for the information system the government still used the BPJS system. The health center is still relatively new, so several problems are still found regarding the administration of medical records, one of which is numbering medical records, storage that is not yet ideal, unclear policies regarding standard operational procedures and a shortage of medical record officers. Currently the puskesmas only has one medical records officer who holds a D3 RM degree, the rest are assisted by officers who have high school/equivalent qualifications. This research was carried out from March to May 2023. The results of the research state that the storage of medical record files at the Parak Karakah Health Center is still not optimal and needs to be improved. Judging from the human resource elements which are still insufficient, the management of medical records has not been carried out well. The large number of files found that do not have folders is also a concern for the future. Storage carried out using a decentralized method is considered not optimal in community health centers because it creates separate medical record files. Ideally, storage in community health centers is carried out using a centralized system because it only accepts outpatients. Keywords: Medical record, Management, Health Center, Factors

A Review Process of ANDA Filling in PMDA (Japan) and Calibration of UV in Accordance to its Regulatory Guidelines

The Abbreviated New Drug Application (ANDA) filing system is an important regulatory process in Japan for the approval of generic drugs. This system allows pharmaceutical companies to submit an application for the marketing and sale of a generic drug, which has already been approved by the regulatory agency in another country. The ANDA system in Japan is similar to that of the United States and Europe, but there are some unique aspects that must be taken into account. For example, in Japan, the regulatory agency requires a separate drug master file for each active pharmaceutical ingredient, which can be a time-consuming process. UV spectrophotometry is a widely used analytical technique for the characterization of pharmaceuticals, including active pharmaceutical ingredients and finished dosage forms. The Shimadzu UV-1800 spectrophotometer is a popular instrument for this purpose, which is widely used in Japan. This instrument has a range of features that make it particularly useful for pharmaceutical analysis, including a wavelength range of 190-1100 nm, a double beam optical system, and a low stray light level. The Shimadzu UV 1800 is also compatible with a range of accessories, such as a multicell holder, which allows for the simultaneous measurement of multiple samples. The combination of the ANDA filing system and UV spectrophotometry using the Shimadzu UV-1800 is an important tool for the development and approval of generic drugs in Japan. The ANDA system allows for a streamlined regulatory process for generic drug approval, while UV spectrophotometry provides a reliable and accurate method for the characterization of pharmaceuticals. Together, these tools help to ensure the safety and efficacy of generic drugs in Japan.

Iatrogenic Incidents in Primary Molar Pulpectomy: A Case Series Report and Literature Review

Pulpectomy is a common treatment for severe carious lesions in primary molars. Care should be taken during pulpectomy of the primary teeth for successive permanent teeth. This case series report aimed to describe the cases of three patients who experienced excessive extrusion of canal filling materials and file separation during primary molar pulpectomy. The presence of separated files or excessive overfilling materials observed around successive permanent tooth germs leads to underdevelopment and may trigger cystic changes owing to abscess formation. The most important aspect is to preserve the unerupted successive developing permanent tooth. Therefore, clinicians should consider the anatomy of the primary molars prior to endodontic treatment, be careful when manipulating instruments during pulpectomy, provide appropriate treatment if iatrogenic incidents occur during endodontic treatment, and perform close follow-up to ensure the successful development and eruption of subsequent permanent teeth.

Стратегии обучения предварительному чтению в учебниках английского языка как иностранного для учащихся средних школ Эфиопии

<p>This study aimed at investigating pre-reading teaching strategies employed in Ethiopian secondary EFL textbooks. The researcher carried out the study based on a descriptive-evaluative research design in the realm of sociocultural perspective of teaching reading in EFL settings. Grades eleven and twelve EFL textbooks were subjects of the study. For this purpose, he documented the softcopy pre-reading instructional tasks of the textbooks in a separate word file. Researcher's self-made checklist about pre-reading teaching strategies adapted from a variety of relevant theoretical and research-based evidence was the data collection instrument. The researcher used content analysis method to analyze the instructional activities. Then, he discussed the results of the data with the participant PhD TEFL instructor and reached an agreement that they analyzed the data consistently. The findings of the study indicate that the textbooks do not use different pre-questioning strategies. For instance, they ask pre-questions to obtain general comprehension abilities, but not to confirm expectations, to extract specific information, and to gain detailed or critical reading facilities. Additionally, they disregard pre-teaching vocabulary and pre-teaching metacognitive reading tasks. Contingent upon the findings, the researcher suggests that secondary EFL textbooks should give due emphasis to different pre-reading teaching strategies necessary to develop students’ reading comprehension facilities.</p>

ANALYSIS OF MEDIUM-TERM RESULTS ACHIEVED AFTER MICROFRACTURES AND PERFORATIONS (DRILLING) IN LOCALIZED CHONDRAL LESIONS IN THE KNEE JOINT

Introduction: The main advantage of perforative techniques is their atraumatic, non-invasiveness and possibly being done under arthroscopic control. Purpose: This study aims to compare two methods of operative techniques in the treatment of chondral lesions of the knee. Materials and methods: The clinical study included 237 symptomatic patients with chondral defects from the period of 2010 – 2018. Patients were divided into 2 groups. The first group included 49 (32.11%) patients with arthroscopic micro-fractures. The second group included 54 (35.49%) patients with arthroscopic subchondral perforation (drilling). The term of follow-up was 36 months. Each patient had at least 4 documented follow-up visits. Results: Results from grading scales – Lysholm, KOS, MRI – scales, as well as our own scale for evaluating knee function (PS) scale, were documented in each patient's separate file. The average pre-operative Lysholm score was 41.5 ± 6.6 in the microfracture group and 43.0 ± 5.6 in the perforation group. At the 36th-month average, Lysholm's score increased to 86.9 ± 7.3 in the microfracture group and to 86.1 ± 6.6 in the perforation group. During the study, it was also found that a correlation exists between the received results and the age of the patient, the size of the chondral defect, and the tracking period. Conclusion: The effectiveness of osteoperforative techniques relies on many factors: the age of the patient, the size of the defect, and the tracking period. In the end, mesenchymal stimulation of chondrogenesis results in positive mid-term results in patients with small-sized chondral lesion.

A Drug Safety Concept (I) to Avoid Polypharmacy Risks in Transplantation by Individual Pharmacotherapy Management in Therapeutic Drug Monitoring of Immunosuppressants.

For several, also vital medications, such as immunosuppressants in solid organ and hematopoietic stem cell transplantation, therapeutic drug monitoring (TDM) remains the only strategy for fine-tuning the dosage to the individual patient. Especially in severe clinical complications, the intraindividual condition of the patient changes abruptly, and in addition, drug-drug interactions (DDIs) can significantly impact exposure, due to concomitant medication alterations. Therefore, a single TDM value can hardly be the sole basis for optimal timely dose adjustment. Moreover, every intraindividually varying situation that affects the drug exposure needs synoptic consideration for the earliest adjustment. To place the TDM value in the context of the patient's most detailed current condition and concomitant medications, the Individual Pharmacotherapy Management (IPM) was implemented in the posttransplant TDM of calcineurin inhibitors assessed by the in-house laboratory. The first strategic pillar are the defined patient scores from the electronic patient record. In this synopsis, the Summaries of Product Characteristics (SmPCs) of each drug from the updated medication list are reconciled for contraindication, dosing, adverse drug reactions (ADRs), and DDIs, accounting for defined medication scores as a second pillar. In parallel, IPM documents the resulting review of each TDM value chronologically in a separate electronic Excel file throughout each patient's transplant course. This longitudinal overview provides a further source of information at a glance. Thus, the applied two-arm concept of TDM and IPM ensures an individually tailored immunosuppression in the severely susceptible early phase of transplantation through digital interdisciplinary networking, with instructive and educative recommendations to the attending physicians in real-time. This concept of contextualizing a TDM value to the precise patient's condition and comedication was established at Halle University Hospital to ensure patient, graft, and drug safety.

Automation of machines working equip-ment calculation using graph theory

Problem. The paper presents an example of using a methodology for automated calculation of working equipment for construction machines, which are represented by hinge-lever mechanisms. The approach employed in the methodology is based on graph theory and provides semi-automatic generation of the mechanism's structure description and automatic formation of systems of equations for its static calculation. Based on the methodology, software has been developed that automates the performance of force calculations in arbitrary positions of the mechanism for different loading schemes. Methodology. To automate the force calculation, an incidence matrix describing the structure of the mechanism is formed and used. Results. The developed software not only provides results in numerical form but also generates images of the mechanism's diagram. Additionally, the software includes exporting capabilities for results to a separate file that can be further used for selecting hydraulic cylinders and pumps, calculating hydraulic systems, and assessing the strength of working equipment components. Originality. Certain rules for numbering mechanism links and joints, as well as methods for indicating the coordinates of the joints and points of application of external forces, have been developed. These rules and methods not only ensure the automatic formation and solution of systems of equations for the mechanism's static equilibrium but also automate the construction of the incidence matrix. Practical value. The developed software and the data representation method proposed by the authors automate the majority of stages in the force calculation of hinge-lever mechanisms for construction machinery. It can be applied not only in the design stage but also before the use of new types of variable working equipment.

Research on the Visualization of Railway Signal Operation and Maintenance Based on BIM + GIS

To adapt to the “fine” and “extensive” management characteristics of railway signal equipment operation and maintenance, achieving real-time and interactive monitoring of signal equipment operation status, and developing an integrated approach to equipment operation and maintenance, this paper takes a comprehensive management perspective. To create a lightweight BIM model, the Garland folding algorithm is utilized to simplify the IFC file format. Building on this approach, the data are divided based on building component division standards to obtain separate files containing geometric information and semantic attributes. The geometric information files are converted to a 3D Tiles format, combining BIM semantic attributes with semantic attribute files through an intermediate format. Dynamic data management is achieved by setting the octree space index structure in combination with a view-frustum culling algorithm. Then, the 3D Tiles target file is imported into the Cesium platform, and Node.js is used to achieve three-dimensional visualization of railway signal operation and maintenance. The proposed method is verified using an inbound signal as an example to assess its feasibility. The results demonstrate the potential of the proposed method to achieve stable integration between BIM equipment full lifecycle maintenance and GIS geographical space display. Railway signal equipment is endowed with comprehensive one-click information query functions for equipment positioning and spatial analysis, improving the efficiency and scientific decision-making level of equipment operation and maintenance.

Digital diagnostics: A computer application for lymph node metastases in cervical cancer

BACKGROUND: Since 2020, staging accuracy improvements in cervical cancer (CC) revealed that major errors occur due to missed metastases to regional lymph nodes. The presence or absence of metastases seriously affects the staging of cancer and, consequently, its treatment methods, since metastases make cancer inoperable.
 AIM: To develop an application to help the doctor in predicting metastases to regional lymph nodes in CC, with the ability of installing on any personal computer regardless of the operating system (Windows, Linux, or Mac OS) and saving data about the patients.
 METHODS: The development was performed on the .NET platform (framework v4.7.2), by means of C# language, based on a proprietary prognostic model using seven blood parameters such as erythrocyte sedimentation rate, erythrocytes, hemoglobin, fibrinogen, D-dimer, and platelet aggregation with adenosine diphosphate and soluble fibrin monomer complexes.
 RESULTS: A window application was developed that automatically calculates the probability of metastases to regional lymph nodes in СС and provides the ability to save the data from the input form and the predicted value into TXT and/or CSV files. TXT and CSV formats are supported in various operating systems. The .txt file allows each individual patients prognosis results to be saved in a separate file for easy printing and attachment to the patients electronic or paper medical record. The CSV file format enables the aggregation of data of all patients by adding line-by-line data from the input form to the end of the file.
 CONCLUSIONS: The developed application facilitates the process of using the patented formula to diagnose metastases to regional lymph nodes in СС at the early stages of examination, which allows choosing the optimal tactics and, consequently, improving the prognosis of the disease.

SEAHORS: Spatial Exploration of ArcHaeological Objects in R Shiny

This paper presents SEAHORS, an R shiny application available as an R package, dedicated to the intra-site spatial analysis of piece-plotted archaeological remains. This open-source script generates 2D and 3D scatter and density plots for archaeological objects located with cartesian coordinates. Many different GIS software already exist for this, but they mostly require specific skills and training to be used and are rarely designed for the particular needs of archaeological applications. The goal of SEAHORS is to make the two and three-dimensional intra-site spatial exploration of archaeological data as user-friendly as possible, in order to give the opportunity to researchers not familiar with GIS and R software to utilise such approaches. SEAHORS has an easily accessible interface and can import data from text and Excel files (.csv and .xls/xlsx respectively) without preformatting. The application includes functions to concatenate columns and to merge databases, for example when spatial data (XYZ coordinates) and analytical data (e.g. taxonomical attribution of faunal remains, typo-technological attributes of artifacts, etc.) are stored in separate files. SEAHORS can generate five types of plots: 3D, 2D and density plots, as well as 2D plots by slices (i.e. subdivisions according to a third dimension) and 2D plots with a modification of the angle of projection (i.e. to explore spatial organization without the constraints of the field grid orientation). SEAHORS has visualization tools with several sorting and formatting options (color, size, etc.) applicable to coordinates and all possible analytical variables (i.e. levels, spits, identified species, taphonomical alterations, etc.). Orthophotos can also be imported and directly used in the program. The application also allows the grouping of objects into new variables by selecting items on the interactive 2D plots. We present an overview of the application’s functions by using the case study of the Cassenade Paleolithic site (France).

SynthRAD2023 Grand Challenge dataset: Generating synthetic CT for radiotherapy.

Medical imaging has become increasingly important in diagnosing and treating oncological patients, particularly in radiotherapy. Recent advances in synthetic computed tomography (sCT) generation have increased interest in public challenges to provide data and evaluation metrics for comparing different approaches openly. This paper describes a dataset of brain and pelvis computed tomography (CT) images with rigidly registered cone-beam CT(CBCT) and magnetic resonance imaging (MRI) images to facilitate the development and evaluation of sCT generation for radiotherapy planning. The dataset consists of CT, CBCT, and MRI of 540 brains and 540 pelvic radiotherapy patients from three Dutch university medical centers. Subjects' ages ranged from 3 to 93 years, with a mean age of 60. Various scanner models and acquisition settings were used across patients from the three data-providing centers. Details are available in a comma separated value files provided with the datasets. The data is available on Zenodo (https://doi.org/10.5281/zenodo.7260704, https://doi.org/10.5281/zenodo.7868168) under the SynthRAD2023 collection. The images for each subject are available in nifti format. This dataset will enable the evaluation and development of image synthesis algorithms for radiotherapy purposes on a realistic multi-center dataset with varying acquisition protocols. Synthetic CT generation has numerous applications in radiation therapy, including diagnosis, treatment planning, treatment monitoring, and surgical planning.

Analyzing piece-plotted artifacts just got simpler: A good solution to the wrong problem?

This paper presents SEAHORS, an R shiny application available as an R package, dedicated to the intra-site spatial analysis of piece-plotted archaeological remains. This open-source script generates 2D and 3D scatter and density plots for archaeological objects located with cartesian coordinates. Many different GIS software already exist for this, but they mostly require specific skills and training to be used and are rarely designed for the particular needs of archaeological applications. The goal of SEAHORS is to make the two and three-dimensional intra-site spatial exploration of archaeological data as user-friendly as possible, in order to give the opportunity to researchers not familiar with GIS and R software to utilise such approaches. SEAHORS has an easily accessible interface and can import data from text and Excel files (.csv and .xls/xlsx respectively) without preformatting. The application includes functions to concatenate columns and to merge databases, for example when spatial data (XYZ coordinates) and analytical data (e.g. taxonomical attribution of faunal remains, typo-technological attributes of artifacts, etc.) are stored in separate files. SEAHORS can generate five types of plots: 3D, 2D and density plots, as well as 2D plots by slices (i.e. subdivisions according to a third dimension) and 2D plots with a modification of the angle of projection (i.e. to explore spatial organization without the constraints of the field grid orientation). SEAHORS has visualization tools with several sorting and formatting options (color, size, etc.) applicable to coordinates and all possible analytical variables (i.e. levels, spits, identified species, taphonomical alterations, etc.). Orthophotos can also be imported and directly used in the program. The application also allows the grouping of objects into new variables by selecting items on the interactive 2D plots. We present an overview of the application’s functions by using the case study of the Cassenade Paleolithic site (France).

Cloudbook Website

Abstract: CloudBook is a notes-taking platform that allows users to create and organize notes in separate files with headings, subheadings, and content. The platform automatically updates the changes made when users save and sign out. While phone notepads are commonly used to write down grocery lists, to-do lists, or notes from presentations, these notes often get lost or become disorganized. Additionally, transferring them to a computer can be challenging. To address this issue, CloudBook was created to provide an organized and accessible format for note-taking. The platform includes features such as checklists, emoticons, and the ability to save external links for further reading. Users can access their notes from any device by logging into their accounts.

Consolidating 23 years of historical data from an irrigated subtropical rice breeding program in Uruguay

AbstractBreeding programs generate vast amount of data which are often scattered in separate files. This hinders the application of modern breeding tools such as multi‐environment analyses and genomic selection. This research work describes the process of consolidating 23 years of phenotypic, pedigree, and genomic records from the Uruguayan national rice (Oryza sativa L.) breeding program, and the features and structure of the resulting database. Using a custom‐made R code, we gathered all the available data from 1997 to 2020 corresponding to field trials, blast disease evaluation nurseries, laboratory analyses of milling and cooking quality, pedigree information, and genomic information for selected advanced breeding lines, and organized it into a relational database. Records of 996 trials in 12 locations over a span of 23 years, 91,636 field plots with information on 14 phenotypic variables, pedigree for 19,447 genotypes, and genomic information regarding 61,260 single nucleotide polymorphism (SNP) markers for 965 genotypes were recovered. The dataset is structured in trials, phenotypes, lines, genomic information, and SNP tables in an easy‐to‐access relational database, which will be a valuable resource for rice breeding.

Spatial extent of dust storm boundaries in the Mars Dust Activity Database

The Mars Dust Activity Database (MDAD) v1.1 is expanded to include all dust storm instance boundaries in MDAD v1.0 from the Mars Color Imager years (Mars Years 28–32). Dust storm boundaries are provided in two formats to ease adoption by the community: as netCDF masks and in comma separated value files. We demonstrate the utility of dust storm boundaries by showing how the frequency of dust storms evolves with season across the surface. The highest dust storm frequencies occur in the southern hemisphere around Ls = 0° and Ls = 270° and in the northern hemisphere around Ls = 180° and Ls = 300°.

CloudBook Website

Abstract: CloudBook is a notes-taking platform that allows users to create and organize notes in separate files with headings, subheadings, and content. The platform automatically updates the changes made when users save and sign out. While phone notepads are commonly used to write down grocery lists, to-do lists, or notes from presentations, these notes often get lost or become disorganized. Additionally, transferring them to a computer can be challenging. To address this issue, CloudBook was created to provide an organized and accessible format for note-taking. The platform includes features such as checklists, emoticons, and the ability to save external links for further reading. Users can access their notes from any device by logging into their accounts.

Altered Functional State and Medicinal Therapeutics

Coronary Artery Disease is caused by plaque buildup in the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. Plaque is made up of deposits of cholesterol and other substances in the artery. Plaque buildup causes the inside of the arteries to narrow over time, which could partially or totally block the blood flow. This process is called atherosclerosis. Coronary artery disease (CAD), when get worst, it is known as coronary artery syndrome (CAS). There are many allopathic medications which can stop, even at starting points of the disease (CAD). Hypolipidemic drugs like statins, fibrates, resins and niacin are well known agents used for prevention of CAD. There are ethnic-based medicinal herbs which can be used to treat or prevent CAD with narrow to moderate range of statistical significance. We compared Rosuvastatin 10 mg with Indian dates (Jujubes) as hypolipidemic agents. This research was conducted at Ghurki Trust Teaching Hospital, jalo park, Lahore, Pakistan. Duration of study was two months. Twenty to seventy years old 60 hyperlipidemic patients of both gender were included in research work with written consent. We divided these patients in two equal groups. Group-I was advised to take Tablet Rosuvastatin 10 mg, twice daily for two months. Group-II was advised to take 500 grams Indian dates for two months. Their baseline parameters like LDL-cholesterol, HDL-cholesterol, systolic/diastolic blood pressure was determined in the hospital laboratory. Separate file was maintained for their name, age, sex, occupation, and address. After two months therapy we compiled data related to tested parameters. Paired t-test was applied to compare changes in all parameters. Their mean values with ± SD before and after treatment were compared and analyzed statistically. It was observed that Rosuvastatin significantly decreased systolic/diastolic blood pressure, LDL-cholesterol, and increased HDL-cholesterol in 27 hyperlipidemic/hypertensive patients. Indian dates used in 30 hyperlipidemic patients significantly decreased systolic blood pressure, and LDL-cholesterol, but insignificant changes were seen in diastolic blood pressure, and HDL-cholesterol. We concluded from the research work that Rosuvastatin is potent hypolipidemic and hypotensive medicine as compared to indian dates.