Sensory Testing In Patients Research Articles

Visceral and cutaneous sensory testing in patients with painful bladder syndrome

Our aims were to determine whether subjects with painful bladder syndrome (PBS) demonstrate characteristics of visceral pain syndromes: visceral hyperalgesia, expanded loci of referral of bladder sensation, increased bladder pain with repetitive filling, lower thresholds to cutaneous stimulation in relevant dermatomes, abnormal response to repetitive cutaneous stimulation in relevant dermatomes, and also to develop easily applied measures for PBS pain evaluation and management. We recruited PBS subjects and control subjects with no bladder pain and with either stress urinary incontinence (SUI) or no incontinence. Subjects underwent three bladder fills up to maximum 300 ml and mapped bladder fullness/discomfort, rating any pain present. Cutaneous current perception thresholds (CPTs) were tested at 2000 Hz, 250 Hz, 5 Hz at C5, T6, T10, T12, S3 dermatomes. Repetitive supra-threshold stimulation in trains of 15 stimuli 2 sec apart were then administered to T12, S3 dermatomes. PBS subjects demonstrated hyperalgesia to bladder filling and tended to sense bladder discomfort at both suprapubic and vulvar/urethral sites. There was no difference in CPTs at any dermatome at any stimulating frequency. PBS and SI subjects tended not to habituate to repetitive stimuli, while asymptomatic controls tended to habituate to repetitive stimulation. PBS subjects demonstrate bladder hyperalgesia and may sense bladder discomfort at sites other than suprapubic. Rating of bladder discomfort and sensory mapping during cystometry usefully distinguishes between PBS subjects and controls.

Quantitative Sensory Testing in Patients with Bell's Palsy

Quantitative Sensory Testing in Patients with Bell's Palsy

Clinical and electrophysiologic correlates of quantitative sensory testing in patients with incomplete spinal cord injury

Hayes KC, Wolfe DL, Hsieh JT, Potter PJ, Krassioukov A, Durham CE. Clinical and electrophysiologic correlates of quantitative sensory testing in patients with incomplete spinal cord injury. Arch Phys Med Rehabil 2002;83:1612-9. Objective: To determine the degree of association among indices of preserved sensation derived from quantitative sensory testing (QST), somatosensory evoked potentials (SEPs), and the clinical characteristics of patients with spinal cord injury (SCI). Design: A controlled correlational study of diverse measures of preserved sensory function. Setting: Regional SCI rehabilitation center in Ontario, Canada. Participants: Thirty-three patients with incomplete SCI and 14 able-bodied controls. Interventions: Not applicable. Main Outcome Measures: QST measures of perceptual threshold for temperature and vibration, American Spinal Injury Association sensory scores (light touch, pinprick), and tibial nerve SEPs. Results: There was a low degree of association (κ) between QST results and sensory scores (|κ|=.05–.44). QST measures yielded greater numbers of patients with SCI being classified as impaired, suggesting a greater sensitivity of QST to detect more subtle sensory deficits. QST measures of vibration threshold generally corresponded to the patients' SEP recordings. QST measures of modalities conveyed within the same tract were significantly (P<.05) correlated (|r|=.46–.84) in patients with SCI, but not in controls, whereas those modalities mediated by different pathways had lower and generally nonsignificant correlations (|r|=.05–.44) in both patients and controls. Conclusions: The low degree of association between QST measures and sensory scores is likely attributable to measurement limitations of both assessments, as well as various neuroanatomic and neuropathologic factors. QST provides more sensitive detection of preserved sensory function than does standard clinical examination in patients with incomplete SCI. © 2002 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation

Quantitative sensory testing in patients with incomplete spinal cord injury

Objective: To examine the utility of quantitative sensory testing (QST) to characterize sensory dysfunction in patients with spinal cord injury (SCI). Design: Perceptual thresholds to warm, cold, cold pain, and vibratory stimuli were investigated using a modified method of “limits.” Method: Three QST trials were administered to six lower leg dermatomes, on two different days, to estimate the reliability of measurement. Setting: Regional Spinal Cord Injury Rehabilitation Center in Ontario, Canada. Subjects: Twenty-one SCI patients with incomplete neurologic deficits and 14 able-bodied controls of similar age. Results: ANOVA revealed significantly ( p < .05) reduced perceptual threshold values (hypoesthesia) for warm, cold, and vibratory sensation in the SCI group. There were no differences between group mean values for cold pain because of the inclusion of patients with hypoalgesia and hyperalgesia. Intraclass correlation coefficient estimates of reliability revealed large between-subject variability in the SCI patients associated with relatively small trial-to-trial variability within each day of testing, and appreciable between-day variances. Conclusions: With QST in SCI there is a need for repeated measurements across days to establish stable baseline measures or outcomes following intervention. QST is a useful adjunct to clinical examination for assessment of preserved sensation.

Correlation of near‐nerve sural conduction and quantified sensory testing in patients with diabetic neuropathy

Correlation of near‐nerve sural conduction and quantified sensory testing in patients with diabetic neuropathy

Correlation of near-nerve sural conduction and quantified sensory testing in patients with diabetic neuropathy

Auditory brainstem evoked potentials (ABEPs) were recorded from 91 newborns from 7 age groups between 26 to 43 weeks of gestation. In addition to the widely used vertex-mastoid derivation, potentials were recorded from three orthogonal electrode configurations, and represented in 3 dimensional voltage-space as three-channel Lissajous' trajectories (3CLTs). ABEPs were evoked by alternating polarity, monaural 75 dBnHL clicks presented at rates of 10/s, 55/s and 80/s. Potentials were also recorded to 45 dBnHL and 15 dBnHL clicks presented at 10/s.3CLT point by point (apex latencies, amplitudes and orientation) as well as planar segment (planar segment position and duration) descriptors, along with peak latencies of the vertex-mastoid peaks, were followed for effects of age, stimulus intensity and rate.ABEPs began to appear consistently at 29 weeks of gestation to high stimulus intensities, with a rapid decrease of ABEP thresholds up to 34 weeks. At 35 weeks, thresholds stabilized approximately at adult values. The results indicate a significant effect of stimulus rate and intensity as well as of gestational age group on apex latencies. The findings also showed changes in apex orientations associated with stimulus rate and intensity interacting with gestational age. 3CLT descriptors enhanced the understanding of these results in relation to developmental and maturational aspects of the auditory system. The results may be explained by maturational change in relative contributions of constituents of the complex ABEP generators.

Sensitivity of cutaneous cold fibers to noxious heat: paradoxical cold discharge

ArticlesSensitivity of cutaneous cold fibers to noxious heat: paradoxical cold dischargeR. R. LongR. R. LongPublished Online:01 May 1977https://doi.org/10.1152/jn.1977.40.3.489MoreSectionsPDF (3 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationCited BySpike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling studyDanielle Sundt, Nikita Gamper, and David B. Jaffe11 December 2015 | Journal of Neurophysiology, Vol. 114, No. 6Responses of intact and injured sural nerve fibers to cooling and mentholAlina Teliban, Fabian Bartsch, Marek Struck, Ralf Baron, and Wilfrid Jänig15 May 2014 | Journal of Neurophysiology, Vol. 111, No. 10Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cellsMasayuki Kurose, and Ian D. Meng15 July 2013 | Journal of Neurophysiology, Vol. 110, No. 2Ocular dryness excites two classes of corneal afferent neurons implicated in basal tearing in rats: involvement of transient receptor potential channelsHarumitsu Hirata, and Michael L. Oshinsky15 February 2012 | Journal of Neurophysiology, Vol. 107, No. 4Temperature perception and nociception1 January 2004 | Journal of Neurobiology, Vol. 61, No. 1Identification and function of thermosensory neurons in Drosophila larvae3 February 2003 | Nature Neuroscience, Vol. 6, No. 3A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction22 July 2004 | The Journal of Physiology, Vol. 545, No. 2Clinical and electrophysiologic correlates of quantitative sensory testing in patients with incomplete spinal cord injuryArchives of Physical Medicine and Rehabilitation, Vol. 83, No. 11Slowly conducting afferents activated by innocuous low temperature in human skin5 August 2004 | The Journal of Physiology, Vol. 535, No. 3Physiological Properties of the Lamina I Spinoparabrachial Neurons in the RatHervé Bester, Victoria Chapman, Jean-Marie Besson, and Jean-François Bernard1 April 2000 | Journal of Neurophysiology, Vol. 83, No. 4Quantitative Analysis of Orofacial Thermoreceptive Neurons in the Superficial Medullary Dorsal Horn of the RatW. D. Hutchison, J. Tsoukatos, and J. O. Dostrovsky1 June 1997 | Journal of Neurophysiology, Vol. 77, No. 6Segmental release of Met-enkephalin-like material from the spinal cord of rats, elicited by noxious thermal stimuliBrain Research, Vol. 484, No. 1-2Response to an itch-producing substance in cat. II. Cutaneous receptor populations with unmyelinated axonsBrain Research, Vol. 413, No. 1Painful sensation induced by a thermal cutaneous stimulusPain, Vol. 17, No. 2Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humansBrain Research, Vol. 274, No. 1Unmyelinated nociceptive units in two skin areas of the ratBrain Research, Vol. 267, No. 1Response properties of high-threshold cutaneous cold receptors in the primateBrain Research, Vol. 244, No. 2 More from this issue > Volume 40Issue 3May 1977Pages 489-502 Copyright & PermissionsCopyright © 1977 the American Physiological Societyhttps://doi.org/10.1152/jn.1977.40.3.489PubMed406366History Published online 1 May 1977 Published in print 1 May 1977 Metrics